Vitamin D deficiency and depression: Causal relationship or artifact?

Rastmanesh, Reza; Beauchet, Olivier; Annweiler, Cédric

doi:10.1002/biof.1028

Cited by 9 publications

(8 citation statements)

References 27 publications

(46 reference statements)

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“…24,25 Adipose tissue may reduce bioavailability of vitamin D and alter vitamin D metabolism, consequently reducing basal concentrations of vitamin D. [26][27][28] Similarly, LTPA may be related to vitamin D homeostasis 28 and has been shown to be a strong determinant of vitamin D status in several studies, including large US cohorts of healthy middle-aged men and women. 29,30 Therefore, the relationship between vitamin D concentrations and depression may differ based on the presence of either overweight/obesity or physical activity.…”

mentioning

confidence: 99%

Association of Serum Vitamin D with Symptoms of Depression and Anxiety in Early Pregnancy

Huang

Arnold

Qiu

et al. 2014

Journal of Women's Health

119

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Objective: To evaluate associations between early pregnancy 25-hydroxyvitamin D (25[OH]D) concentrations and antepartum depression and anxiety symptoms and potential modifiers thereof. Materials and Methods: In a pregnancy cohort (N = 498), we examined cross-sectional associations of early pregnancy (mean = 15.4 weeks gestation) serum 25[OH]D concentrations and depression and anxiety symptoms. Symptoms were measured using Depression, Anxiety, and Stress Scales (DASS-21) and Patient Health Questionnaire Depression Module (PHQ-9) instruments. Regression models were fit and effect modification by prepregnancy body mass index and leisure-time physical activity (LTPA) were assessed using interaction terms and stratified analyses. ( < 28.9 ng/mL) had 1.11 higher PHQ-9 scores than those in the highest quartile ( ‡ 39.5 ng/mL, p < 0.05). However, associations were attenuated and statistically insignificant in fully adjusted models. Inverse associations of 25[OH]D with depression symptoms were significant among participants who reported no LTPA, but not among women who reported any LTPA (interaction p = 0.018). Conclusions: Our study provides modest evidence for inverse cross-sectional associations of early pregnancy maternal vitamin D concentrations with antepartum depression symptoms. We also observed that these associations may be modified by physical activity.

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mentioning

confidence: 99%

Association of Serum Vitamin D with Symptoms of Depression and Anxiety in Early Pregnancy

Huang

Arnold

Qiu

et al. 2014

Journal of Women's Health

119

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“…The findings enable causal reasoning and offer new therapeutic perspectives. [2][3][4][5][6][7][8][9][10]…”

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confidence: 99%

The Role of Vitamin D in Depression: From a Curious Idea to a Therapeutic Option

Annweiler¹,

Rastmanesh²,

Richard‐Devantoy³

et al. 2013

J. Clin. Psychiatry

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“…The link between vitamin D concentrations and depression has been suggested to be less straightforward than commonly assumed. The association may have been overestimated, particularly in older people, since both hypovitaminosis D and depression are highly prevalent in this age group (Rastmanesh et al, 2012) (see also Table 1).…”

Section: Vitamin D and The Brain And The Rationale For Its Use In Depressionmentioning

confidence: 99%

“…The correlation between low vitamin D levels and depressive symptoms does not necessarily indicate that hypovitaminosis D plays a causal role in depression, since a wide range of potential confounders, such as age, dietary intake, physical exercise, time spent outdoors, as well as alcohol and tobacco may play a role (Bertone-Johnson, 2009). It is conceivable that low vitamin D levels result from depression, since depressed mood and apathy may lead to a decrease in exposure to sunlight or intake of food rich in vitamin D (Rastmanesh et al, 2012). A decrease in vitamin D concentrations may therefore be an antecedent or a consequence of depression, and causality should be examined in prospective studies assessing mood changes over time.…”

Section: Vitamin D and The Brain And The Rationale For Its Use In Depressionmentioning

confidence: 99%

The use of vitamin D in depression

Lange

Nakamura

et al. 2021

JFB

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Vitamin D has increasingly been associated with the pathophysiology of mental illness and has been suggested to have beneficial effects on depression in adults. Epidemiological studies concerning vitamin D and depression have found inconsistent results and many have significant methodological limitations. The available evidence suggests that depressed individuals show reduced vitamin D concentrations compared to controls without depression. Despite the available findings suggesting that hypovitaminosis D elevates the risk of depressive mood, the evidence of observational and interventional studies is insufficient to establish causality between low vitamin D levels and the occurrence of depression. The question of whether vitamin D sufficiency has protective efficacy against incident depression or recurrence requires future investigation. In order to examine the therapeutic efficacy of vitamin D, further well-designed, large-scale, long-term intervention trials of vitamin D supplementation in people of different age groups with depressive symptoms, diagnosed depression, postpartum depression or other depressive disorders are warranted. In short, current evidence cannot definitively establish whether vitamin D deficiency is a risk factor in the development of depression or whether vitamin D is effective in the treatment of depression.

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Vitamin D deficiency and depression: Causal relationship or artifact?

Cited by 9 publications

References 27 publications

Association of Serum Vitamin D with Symptoms of Depression and Anxiety in Early Pregnancy

Association of Serum Vitamin D with Symptoms of Depression and Anxiety in Early Pregnancy

The Role of Vitamin D in Depression: From a Curious Idea to a Therapeutic Option

The use of vitamin D in depression

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