Vitamin D deficiency and deafness.

Brookes, E.; Morrison, A. W.

doi:10.1136/bmj.283.6286.273-a

Cited by 37 publications

(30 citation statements)

References 4 publications

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“…Rats with hypocalcemia secondary to vitamin D deprivation exhibit depressed cochlear microphonic amplitudes and elevated thresholds (Ikeda et al 1987a). In humans, vitamin D deficiency (Brookes 1985;Ikeda et al 1989), renal failure (Bergstrom et al 1973;Johnson and Mathog 1976), and hypoparathyroidism (Ikeda et al 1987b)-conditions that cause low serum and presumed low endolymph Ca 2+ concentrations-are associated with sensorineural hearing loss.…”

Section: Introductionmentioning

confidence: 99%

Low Endolymph Calcium Concentrations in deafwaddler2J Mice Suggest that PMCA2 Contributes to Endolymph Calcium Maintenance

Wood

Muchinsky

Filoteo

et al. 2004

JARO

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In vertebrates, transduction of sound into an electrochemical signal is carried out by hair cells that rely on calcium to perform specialized functions. The apical surfaces of hair cells are surrounded by endolymphatic fluid containing calcium at concentrations that must be maintained by active transport. The mechanism of this transport is unknown, but an ATPdependent pump is believed to participate. Mutation of the Atp2b2 gene that encodes plasma membrane calcium ATPase type 2 (PMCA2) produces the deaf, ataxic mouse: deafwaddler 2J (dfw 2J ). We hypothesized that PMCA2 might transport calcium into the endolymph and that dfw 2J mice would have low endolymph calcium concentrations, possibly contributing to their deafness and ataxia. First, using immunocytochemistry, we demonstrated that PMCA2 is present in control mice inner and outer hair cell stereocilia where it could pump calcium into the endolymph and that PMCA2 is absent in dfw 2J stereocilia. Second, using an aspirating microelectrode and calcium-sensitive fluorescent dye, we found that dfw 2J mice endolymph calcium concentrations are significantly lower than those of control mice. These findings suggest that PMCA2, located in hair cell stereocilia, contributes significantly to endolymph calcium maintenance.

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Section: Introductionmentioning

confidence: 99%

Low Endolymph Calcium Concentrations in deafwaddler2J Mice Suggest that PMCA2 Contributes to Endolymph Calcium Maintenance

Wood

Muchinsky

Filoteo

et al. 2004

JARO

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“…A significant reduction in the brainstem amplitude has been observed in vitamin D depleted diet in albino rats by Brooks and Morrison [19].…”

Section: Introductionmentioning

confidence: 83%

“…The role of vitamin D deficiency has been attributed to cochlear deafness, Meniere's disease and otosclerosis including cochlear otosclerosis representing with trough shaped pure tone audiogram with a dip during 1 and 2 kHz frequencies [17].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency in E.N.T. Patients

Taneja¹,

Taneja

2012

Indian J Otolaryngol Head Neck Surg

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A prospective study to observe the prevalence of deficiency of vitamin D in out patients of otolaryngology clinic at Indian Institute of ear diseases, Muzaffarnagar. The patients attending outpatient of otolaryngology clinic with various complaints and not responding to conventional treatment were advised for assessment of vitamin D [25 (OH)D] level in blood. The age, sex, occupation, colour of skin, chief complaints, obesity, provisional diagnosis, and incidence of sun exposure was noted in all cases. A total of 86 patients were examined, maximum patients were in the age group of 7-15 years. The chief complaints in majority of the patients were sore throat with recurrent upper respiratory tract infection. Only in three patient's vitamin D level was found to be with in normal limits. In rest 83 (96.51 %) it was either deficient 57 (66.28 %) or insufficient 21 (24.42 %). The incidence of vitamin D deficiency is extremely common in Ear Nose Throat disease (E.N.T.) patients. The results of vitamin supplementation were promising in cases of benign paroxysmal positional vertigo with cervical spondylosis and URTI with asthma, empirical supplementation of vitamin D in all E.N.T. patients not responding to conventional treatment is worth trying. At place of sun screen, use of pomegranates and blueberries may be encouraged to prevent sunburn and eliminate Vitamin D deficiency.

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“…Lowered levels of 25(OH)D was found to be independently associated with higher AIX, lower FMD and RHI. I chose this study because it associates vitamin D status with a variety of cardiovascular risk factors and thus allowing potential insight in to the underlying mechanism vitamin D's protective effects [10][11][12][13]. This study, however, is also limited because it did not take into account other factors such as physical activity which may account for the observations seen.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency to Ill Health Essay

Dubey¹

2017

JOENTR

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Vitamin D deficiency and deafness.

Cited by 37 publications

References 4 publications

Low Endolymph Calcium Concentrations in deafwaddler2J Mice Suggest that PMCA2 Contributes to Endolymph Calcium Maintenance

Low Endolymph Calcium Concentrations in deafwaddler2J Mice Suggest that PMCA2 Contributes to Endolymph Calcium Maintenance

Vitamin D Deficiency in E.N.T. Patients

Vitamin D Deficiency to Ill Health Essay

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