Vitamin D deficiency and COVID-19: A case-control study at a tertiary care hospital in India

Nimavat, Nirav; Singh, Shruti; Singh, Pratibha; Singh, Sunil Kumar; Sinha, Nishi

doi:10.1016/j.amsu.2021.102661

Cited by 27 publications

(31 citation statements)

References 43 publications

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Section: Discussionmentioning

confidence: 99%

“…Recently, researchers have attempted to corelate the incidence, severity and mortality of COVID-19 with serum Vitamin D levels [ 9 – 12 ]. Nimavat et al [ 9 ], in their case control study comprising of 156 cases of COVID-19 and 204 controls, they found no statistical difference between mean Vitamin D levels among cases and controls (19.7 ± 8.4 ng/ml and 20.0 ± 11.7 ng/ml respectively) but the status of Vitamin D was positively associated with severity of the disease. Jain et al [ 10 ] compared serum vitamin D levels among asymptomatic and severely ill COVID-19 patients wherein the levels were 27.89 ± 6.21 and 14.35 ± 5.79 ng/ml in the former and latter groups respectively, the difference being highly significant.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies state that vitamin D levels are directly related to the severity and morbidity of these diseases [ 8 ]. Researchers have also found out a link between COVID-19 infection, its severity and mortality with serum levels of vitamin D, most studies yielding a positive correlation [ 9 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Are Low Serum Vitamin D Levels a Risk Factor for Advent of COVID-19 Associated Rhinocerebral Mucormycosis: A Preliminary Case Control Study

Popli

Gupta

Singh

et al. 2022

Indian J Otolaryngol Head Neck Surg

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To determine whether low serum vitamin D level is a risk factor for development of Rhinocerebral mucormycosis in COVID-19 afflicted patients. A case control study was conducted in a tertiary care hospital utilizing the archived records of COVID-19 afflicted Rhinocerebral mucormycosis cases and age and gender matched controls. The mean value (± standard deviation) of vitamin D level in patients with Mucormycosis was 19.65 ± 13.07 ng/ml and in control subjects it was 27.88 ± 18.04 ng/ml.There was a significant difference between groups ( p = 0.02). Thus, low Vitamin D level may be implicated as a risk factor for the advent of mucormycosis in a COVID-19 afflicted patient and therefore Vitamin D supplements may be provided to such patients to achieve normal serum levels.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Are Low Serum Vitamin D Levels a Risk Factor for Advent of COVID-19 Associated Rhinocerebral Mucormycosis: A Preliminary Case Control Study

Popli

Gupta

Singh

et al. 2022

Indian J Otolaryngol Head Neck Surg

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“…Despite the fact that the deficiency of the predefined micronutrients could be associated with impaired immune defense in COVID-19 patients, the prescription of a high dose of zinc gluconate, vitamin C, or both did not significantly improve symptoms faster than the standard of care [255]. Nevertheless, recent studies have reported that vitamin D deficiency is strongly associated with COVID-19 clinical severity [256] and that the daily oral high dose of vitamin D3 could reduce the inflammatory markers associated with COVID-19 without any side effects [257].…”

Section: Zinc and Vitamin Supplementsmentioning

confidence: 96%

Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview

et al. 2021

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Respiratory viruses represent a major public health concern, as they are highly mutated, resulting in new strains emerging with high pathogenicity. Currently, the world is suffering from the newly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus is the cause of coronavirus disease 2019 (COVID-19), a mild-to-severe respiratory tract infection with frequent ability to give rise to fatal pneumonia in humans. The overwhelming outbreak of SARS-CoV-2 continues to unfold all over the world, urging scientists to put an end to this global pandemic through biological and pharmaceutical interventions. Currently, there is no specific treatment option that is capable of COVID-19 pandemic eradication, so several repurposed drugs and newly conditionally approved vaccines are in use and heavily applied to control the COVID-19 pandemic. The emergence of new variants of the virus that partially or totally escape from the immune response elicited by the approved vaccines requires continuous monitoring of the emerging variants to update the content of the developed vaccines or modify them totally to match the new variants. Herein, we discuss the potential therapeutic and prophylactic interventions including repurposed drugs and the newly developed/approved vaccines, highlighting the impact of virus evolution on the immune evasion of the virus from currently licensed vaccines for COVID-19.

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“…This point has incited studies to investigate the effect of an imperfect or lower level of Vitamin D, linking it with many other severe health conditions like autoimmune disorders, cardiovascular disease (CVD), hypertension (HTN), and other diseases. Similarly, various studies have been conducted on the positive benefits of Vitamin D on the early recovery and prevention of COVID-19 [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Vitamin D Levels and Severity in Illness in COVID-19 Patients: A Cross-Sectional Study

Nimavat¹,

Singh²,

Patel³

et al. 2022

Cureus

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Introduction: The coronavirus disease 2019 (COVID-19) pandemic hit the world badly with high mortality. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection increased the COVID-19 burden among developed and developing countries due to the unavailability of proven treatment options. Vitamin D has many important anti-inflammatory, immunomodulator, and anti-viral functions. The present study was conducted to evaluate the relationship between Vitamin D in COVID-19.Methods: A cross-sectional study was conducted at a tertiary care hospital in Patna, India. All the patients were enrolled during the period of 3.5 months. A chemiluminescence-based immunoassay analyzer was used to quantify Vitamin D among COVID-19 patients. The study compared Vitamin D deficiency and insufficiency among different groups, i.e., age, sex, BMI, comorbidity, etc. Diabetes and hypertension were evaluated as risk factors for mortality.Results: A total of 225 patients were investigated. Of these, 13.6% had Vitamin D deficiency and 38.9% had insufficiency. Vitamin D level was statistically significant among different age groups, sex, and smokers. Patients aged >60 years were 23 times more likely to have a severe illness (adjusted OR (aOR) 23.53, 95%CI 4.67-118.61), whereas those aged 40 to 60 years were 11 times more likely to have a severe illness (aOR 10.86,. Patients with many comorbidities, on the other hand, had a tenfold greater chance of severe . A deficiency of vitamin D increased the chance of a serious illness by nearly five times (aOR 4.72, 95%CI 1.31-17.03).Conclusion: Vitamin D level was associated with severity of illness; it can be used to estimate the prognosis of COIVD-19 patients and aid in the modification of treatment protocols.

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Vitamin D deficiency and COVID-19: A case-control study at a tertiary care hospital in India

Cited by 27 publications

References 43 publications

Are Low Serum Vitamin D Levels a Risk Factor for Advent of COVID-19 Associated Rhinocerebral Mucormycosis: A Preliminary Case Control Study

Are Low Serum Vitamin D Levels a Risk Factor for Advent of COVID-19 Associated Rhinocerebral Mucormycosis: A Preliminary Case Control Study

Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview

The Relationship Between Vitamin D Levels and Severity in Illness in COVID-19 Patients: A Cross-Sectional Study

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