Vitamin D deficiency and anemia: a cross-sectional study

Sim, John J.; Peter, Thomas; Liu, In Lu A.; Meguerditchian, Samuel O.; Kumar, Victoria A.; Kujubu, Dean A.; Rasgon, Scott

doi:10.1007/s00277-009-0850-3

Cited by 183 publications

(180 citation statements)

References 21 publications

(25 reference statements)

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“…Normalization of levels of vitamin D in these tissues can provoke an adequate amount of substrate for the extra-renal hydroxylases, and these high concentrations of 1. 25 (OH) 2 D in hematopoietic tissues could directly activate precursor erythroid cells [22]. There are authors who postulate that the administration of 25(OH)D is more advantageous for improving anemia in patients with Patients with Chronic Kidney Disease renal insufficiency than 1.25(OH) 2 D administration; this is achieved by administering substrate to the bone marrow to synthesize 1.…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease

López-Ramiro¹

2017

AJCEM

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Introduction: Vitamin D exercises pleiotropic effects independently of calcium and phosphorous homeostasis.Purpose: To analyze the possible correlation between levels of 25-hydroxy vitamin D (25(OH)D) and other parameters of patients with chronic kidney disease (CKD). Patients and methods: One hundred and forty-five patients with stage-5 CKD were studied (mean age 65.9 ± 14.6 years; 74 males and 71 females; Levels of 25(OH)D, age, bone alkaline phosphatase, procollagen I amino-terminal propeptide, carboxyterminal telopeptide of collagen I, intact parathyroid hormone (PTH), bio-PTH, hemoglobin, hematocrit, urea, creatinine, total proteins, albumin, iron, iron saturation index, calcium, phosphorous, total alkaline phosphatase, serum CO 2 , cholesterol, triglycerides, C-reactive protein, prealbumin, ferritin, proBNP, and fibroblast growth factor-23 (FGF-23) were determined. Spearman's correlation coefficient and p values were analyzed. Results: This work show a positive correlation between levels of 25(OH)D and anemia (i.e., hemoglobin, hematocrit, iron, iron saturation index, and ferritin). Conclusion: These results show the close relationship between the degree of anemia in patients with CKD and 25(OH)D levels. It is of great importance to maintain levels of 25(OH)D in patients with advanced-stage CKD, as this can decrease anemia levels and, in turn, lower quantities of erythropoietin would be necessary to maintain hematocrit.

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Section: Discussionmentioning

confidence: 99%

Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease

López-Ramiro¹

2017

AJCEM

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“…Toxic lead levels can impair the synthesis of the most important Vitamin D metabolite, dihydroxy Vitamin D (Calcitriol), by inhibiting renal absorption [5]. Till date only one published study has examined the relationship between Vitamin D deficiency and anemia, and has found positive association between the two in adults [6].…”

Section: Introductionmentioning

confidence: 99%

Status of Serum Calcium, Vitamin D and Parathyroid Hormone and Hematological Indices Among Lead Exposed Jewelry Workers in Dhaka, Bangladesh

2016

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Jewelry utilizes lead either directly or as a base metal. Costume jewelry requires lead before molding and plating the product with valuable metals. Therefore, such ornaments have a great potential to release heavy metals having health hazards. Also, jewelry makers engaged in preparing German silver, an alloy, apply lead in smelting, alloying, rolling and milling silver wires and pieces. The metal is taken up by blood, soft tissues and bone. The biological effects of lead are dependent upon the level and duration of exposure. Lead inhibits three enzymes of heme biosynthesis-d-amino-levulinic-acid dehydratase (ALAD), coproporphyrin oxidase, and ferrochelatase, impairing heme synthesis and depressing serum level of erythropoietin resulting in decreased hemoglobin synthesis. Lead exposure also affects calcium metabolism and impair the synthesis of Calcitriol. In the present study, jewelry makers from Dhaka, Bangladesh, were shown to have significantly high levels of lead, protein, albumin, and parathormone in their blood, and significantly high amount of zinc-protoporphyrin and d-amino-levulinic-acid in their urine. The control group, on the other hand showed significantly higher amounts of calcium (both total and ionized form) Vitamin D 3 and non-activated erythrocyte ALAD in their blood, along with hemoglobin. It might be due to inhibition of 1-a-hydroxylase enzyme in renal tubules. Lead causes nephro-toxicity and inhibits 1-a-hydroxylase enzyme leading to decreased calcitriol synthesis resulting in impaired calcium absorption across gastro-intestinal tract and renal tubules. Low Vitamin D 3 and significantly increased Parathyroid hormone (PTH) in study group has been found.

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“…Only one published study to date has examined the relationship between vitamin D deficiency and anaemia (5) , and found a positive association between the two in adults. To our knowledge, this has not yet been studied in children.…”

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confidence: 99%

Anaemia, lead poisoning and vitamin D deficiency in low-income children: do current screening recommendations match the burden of illness?

Kersey

Ming

Cutts

2011

Public Health Nutr.

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Objective: Low-income children are routinely screened for anaemia and elevated blood lead levels (EBLL) but not for vitamin D deficiency. We sought to determine the relative prevalence of and the relationship among vitamin D deficiency, anaemia and EBLL among healthy low-income paediatric clinic patients. Design: Retrospective chart review. Setting: Paediatric outpatient clinic in an urban safety net hospital in a northern US state. Subjects: Healthy toddlers and children under 6 years of age (n 127) who were seen for a routine well child check-up (WCC). Results: The prevalence of vitamin D insufficiency (25-hydroxyvitamin D (25(OH)D) , 30 ng/ml) was 62 %; the prevalence of vitamin D deficiency (25(OH)D , 20 ng/ml) was 29 %. These rates were far higher than those for anaemia (Hb , 11?0 g/dl) at 10 %, EBLL (Pb . 9 mg/dl) at 1 % or even mildly EBLL (Pb 5-9 mg/dl) at 4 % (range: 1-11). There was no relationship among any of the following: vitamin D status, anaemia or EBLL. The vast majority of children with vitamin D deficiency had both normal Hb (86 %) and Pb level (100 %). After controlling for child's age, gender and race/ethnicity, there was no association between Hb (continuous, g/dl) and vitamin D deficiency (adjusted OR (aOR) 5 0?97, 95 % CI 0?64, 1?47; P 5 0?88). The only significant predictor of vitamin D deficiency was increasing age in years (aOR 5 1?39, 95 % CI 1?03, 1?86; P 5 0?03). None of these associations changed materially when deficiency was defined as ,15 ng/ml. Conclusions: Vitamin D deficiency was far more common than anaemia or EBLL, and Hb and Pb status were not predictors of vitamin D status.

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Vitamin D deficiency and anemia: a cross-sectional study

Cited by 183 publications

References 21 publications

Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease

Correlation Between Levels of 25-Hydroxy-Vitamin D and Degree of Anemia in Patients with Chronic Kidney Disease

Status of Serum Calcium, Vitamin D and Parathyroid Hormone and Hematological Indices Among Lead Exposed Jewelry Workers in Dhaka, Bangladesh

Anaemia, lead poisoning and vitamin D deficiency in low-income children: do current screening recommendations match the burden of illness?

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