Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy

Lange, Christian; Bojunga, Jörg; Ramos-Lopez, Elizabeth; Wagner, Michael; Hassler, Angela; Vermehren, Johannes; Herrmann, Eva; Badenhoop, Klaus; Zeuzem, Stefan; Sarrazin, Christoph

doi:10.1016/j.jhep.2010.08.036

Cited by 208 publications

(173 citation statements)

References 47 publications

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“…Our total search yielded 775 entries. We identified six eligible publications (Arteh et al, 2010;Lange et al, 2011;Amanzada et al, 2013;Kitson et al, 2013;Petta et al, 2013;White et al, 2013) concerning the association between vitamin D and severity of liver fibrosis in patients infected with chronic hepatitis C. Among these studies, two (Arteh et al, 2010;Petta et al, 2013) were consecutive studies, one (Lange et al, 2011) was a retrospective study, one (White et al, 2013) was a cross-sectional study, one (Kitson et al, 2013) was a CHARIOT study, and one was a cohort study (Amanzada et al, 2013).…”

Section: Literature Searchmentioning

confidence: 99%

“…Of these six studies, three (Lange et al, 2011;Amanzada et al, 2013;Petta et al, 2013) were conducted in Europe, two (Arteh et al, 2010;White et al, 2013) …”

Section: Study Characteristicsmentioning

confidence: 99%

“…n c : number of cases; n p : number of participants; M: male; F: female; CHARIOT: collaborative group hepatitis C study using high-dose Pegasys RBV induction dose in genotype one; HPLC: high performance liquid chromatography; LC: liquid chromatography; MS: mass spectrometry; G1, 2, 3, 4: hepatitis C genotype 1, 2, 3, or 4 infection; NA: not available United States, and one (Kitson et al, 2013) in Australia. The five (Arteh et al, 2010;Amanzada et al, 2013;Kitson et al, 2013;Petta et al, 2013;White et al, 2013) studies assessed included a review of serum 25(OH) D status, and one (Lange et al, 2011) on 25(OH)D 3 and 1,25(OH) 2 D 3 status. Three studies (Amanzada et al, 2013;Kitson et al, 2013;Petta et al, 2013) included patients with chronic hepatitis C genotype 1 infection, one (Lange et al, 2011) with chronic hepatitis C genotype 1, 2, or 3-infection, one (White et al, 2013) with chronic hepatitis C genotype 1, 2, 3, or 4-infection, and one (Arteh et al, 2010) did not specify the kind of HCV type.…”

Section: G1mentioning

confidence: 99%

“…The five (Arteh et al, 2010;Amanzada et al, 2013;Kitson et al, 2013;Petta et al, 2013;White et al, 2013) studies assessed included a review of serum 25(OH) D status, and one (Lange et al, 2011) on 25(OH)D 3 and 1,25(OH) 2 D 3 status. Three studies (Amanzada et al, 2013;Kitson et al, 2013;Petta et al, 2013) included patients with chronic hepatitis C genotype 1 infection, one (Lange et al, 2011) with chronic hepatitis C genotype 1, 2, or 3-infection, one (White et al, 2013) with chronic hepatitis C genotype 1, 2, 3, or 4-infection, and one (Arteh et al, 2010) did not specify the kind of HCV type. Four studies (Baur et al, 2012;Corey et al, 2012;Weintraub et al, 2012;Ladero et al, 2013) were excluded because they did not report usable data.…”

Section: G1mentioning

confidence: 99%

“…A lower serum 25(OH) D level significantly correlates with an increasing risk of advanced fibrosis and a higher severity of necroinflammatory activity has been related to different populations with individuals infected with chronic hepatitis C (Lange et al, 2011;Kitson et al, 2013;Petta et al, 2013). However, the results are not consistent in different studies and by race (Kitson et al, 2013;White et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis

Luo

Ling

et al. 2014

J. Zhejiang Univ. Sci. B

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Abstract:To conduct a systematic review of group studies assessing the association of serum vitamin D status with the severity of liver fibrosis in chronic hepatitis C patients using meta-analysis. The relevant research literatures were identified by searching PubMed and EMBASE databases prior to October 2013 with no restrictions. We included group studies that reported odds ratio (OR) estimates with 95% confidence intervals (CIs) or a mean with standard deviation (SD) for the association between serum vitamin D status and the severity of liver fibrosis in chronic hepatitis C patients. Approximately 8321 participants from several countries were included in this analysis. Six studies on serum vitamin D status and the severity of liver fibrosis were included in this meta-analysis. ORs with 95% CIs were extracted from four studies and the pooled ORs were 0.866 (95% CI, 0.649 to 1.157). The means with SDs were extracted from three studies and the pooled means were −0.487 (95% CI, −0.659 to −0.315). There was statistically significant heterogeneity among the mean data extracted studies (P=0.029; I 2 =71.8%) but not among the OR data extracted studies (P=0.061; I 2 =55.6%). Finally, results from the mean data extracted studies suggest that lower serum vitamin D is a risk factor for the severity of liver fibrosis in chronic hepatitis C patients. However, there is no conclusive evidence on this association because of inconsistencies between the OR data extracted studies and the mean data extracted studies.

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Section: Literature Searchmentioning

confidence: 99%

“…Of these six studies, three (Lange et al, 2011;Amanzada et al, 2013;Petta et al, 2013) were conducted in Europe, two (Arteh et al, 2010;White et al, 2013) …”

Section: Study Characteristicsmentioning

confidence: 99%

Section: G1mentioning

confidence: 99%

Section: G1mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis

Luo

Ling

et al. 2014

J. Zhejiang Univ. Sci. B

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Liver Disease

McClain

Hill

Marsano

2012

Present Knowledge in Nutrition

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Serum vitamin D level not correlated with hepatitis B virus replication in patients with chronic hepatitis B virus infection

Yang

Tseng

Chen

et al. 2017

Adv in Digestive Medicine

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Backgrounds: Vitamin D is an important immune modulator in chronic liver diseases. The study aims to investigate the relationship between vitamin D and hepatitis B virus replication. Methods: This was a prospective study. Hepatitis B virus (HBV) carriers were enrolled from May to Oct 2014 in Taipei Tzu Chi Hospital. All have positive hepatitis B surface antigen (HBsAg) for more than 6 months. Serum alanine aminotransferase (ALT), quantitative HBsAg (qHBsAg), HBV DNA and 25(OH)D3 were measured in each participant. Results: 204 patients (male 103; mean age 47.86 ± 10.22 years) with chronic HBV infection (94.12% HBeAg-negative) were enrolled. Of them, 13 (6.4%) had severe deficiency (25(OH)D3 ＜ 10 ng/mL), 176 (86.3%) insufficiency (25(OH)D3 ≥ 10 and ＜ 30 ng/mL) and 15 (7.4%) adequate (25(OH)D3 ≧ 30 ng/mL) vitamin D levels. In the regard of age and sex, there was no difference in vitamin D levels. Using linear regression analysis, there was no correlation between serum vitamin D and HBV DNA/ qHBsAg levels. While serum vitamin D levels were categorized by quartiles, there was no association between vitamin D levels and HBV DNA/qHBsAg levels using univariate and multivariate analyses. Conclusions: In this study, 92.6% of patients with chronic HBV infection have inadequate vitamin D levels. Serum vitamin D levels do not correlate with the markers of HBV replication including serum HBV DNA and qHBsAg levels.

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Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy

Cited by 208 publications

References 47 publications

Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis

Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis

Liver Disease

Serum vitamin D level not correlated with hepatitis B virus replication in patients with chronic hepatitis B virus infection

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