Vitamin D contributes to mast cell stabilization

Liu, Z.-Q.; Li, X.-X.; Qiu, Shuqi; Yu, Yingxin; Li, M.-G.; Yang, Liteng; Li, L.-J.; Wang, S.; Zheng, Pengyuan; Yang, Ping‐Chang

doi:10.1111/all.13110

Cited by 56 publications

(45 citation statements)

References 23 publications

(28 reference statements)

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“…111 For example, 25% and 45% of the phenol used in an original PF sample was substituted with three different types of lignins (pine KL, soda anthraquinone flax lignin and sulphonated SKL). 112,113 As such in their effort to synthesize lignin based PF adhesives Jin and his group used enzymatic hydrolysis lignin (EHL), which had a comparatively low molecular weight (900 -1300 g/mol). Three of the above-mentioned samples (45% soda anthraquinone flax lignin based novolac, 25% sulfonated SKL based novolac and 45% sulfonated SKL based novolac) showed a single T g , positioned well between the T g s of the pure lignin and the commercial PF resin samples.…”

Section: -100mentioning

confidence: 99%

Thermal properties of lignin in copolymers, blends, and composites: a review

2015

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The need for renewable alternatives to conventional petroleum based polymers has been the motivation for work on biobased composites, blends and materials whose foundations are carbon neutral feedstocks. Lignin, an abundant plant derived feedstock, and waste byproduct of the cellulosic ethanol and pulp and paper industry, qualifies as a renewable material. Despite the fact that it is often difficult to blend lignin with other polymers due to its complex structure and reactivity, published research over the past decade, has focused on issues such as lignin miscibility with other polymers, the thermal and mechanical strength behavior of its copolymers and its fractions as well as efforts of tuning its thermal properties via chemical modifications and other means. As such this effort now attempts to offer a comprehensive overview that largely discusses the importance of these processes with the aim toward effective, cost efficient and environmentally friendly means that may allow the utilization of this important and largely ignored biopolymer.

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Section: -100mentioning

confidence: 99%

Thermal properties of lignin in copolymers, blends, and composites: a review

2015

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“…The immunomodulatory activity of vitamin D seems to work also for those cells having a major role in the allergic response, such as mast cells, as vitamin D participates in stabilizing their function, whereas its deficiency should promote the activation of these cells. 172,173 The immunoregulatory role of vitamin D in mast cell-mediated allergy is assessed by the ability of these leukocytes to express enzymes able of activating the vitamin D biochemical pathway, such as CYP27A1 and CYP27B1. 174,175 Most probably, mast cells are able to activate 1α,25 (OH) 2 D 3 vitamin from the precursor 25OHD 3 via the CYP27B1 activity, thus dampening immunoglobulin E-mediated hypersensitivity, a mechanism that has also been reported for adipocytes.…”

Section: Role In Acquired and Regulatory Immunitymentioning

confidence: 99%

The Role of Vitamin D in the Immune System as a Pro-survival Molecule

Chirumbolo

Bjørklund

Sboarina

et al. 2017

Clinical Therapeutics

105

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“…Mast cells are well known to be required in allergen-induced diarrhea (22)(23)(24). As it has been reported that vitamin D3 suppressed the mast cell activation (25,26), we presume that cholecalciferol might also possibly control the allergic diarrhea through the suppressive effect on mast cells in addition to that on CD4 1 T cells in our model. In addition, several studies reported that mast cells could express CD69 on the cell surface in some situations (27,28).…”

Section: Discussionmentioning

confidence: 70%

Effect of Cholecalciferol in Food Allergy Mouse Model Is Associated with Decrease of CD69<sup>+</sup> CD4<sup>+</sup> T Cells

Zaim

Ashino

Osaka

et al. 2019

J Nutr Sci Vitaminol

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Food allergy prevalence is increasing all over the world. Recent epidemiologic studies have shown the link between vitamin D3 insufficiency and food allergy occurrence. In this study, we investigated the effect of supplementation with cholecalciferol, a widely used form of vitamin D3, on food allergy using an experimental mouse model. In wild-type BALB/c mice which were sensitized and challenged with an experimental allergen, ovalbumin, a clinical symptom of food allergy, diarrhea, was significantly induced with the elevation of immunoglobulin E level and the increases of T helper 2 cytokine productions, such as interleukin-4,-5, and-13 (p,0.05), whereas no change in T helper 1 cytokine production, such as interferon-g, was observed. It was also found that cell population of CD69 1 CD4 1 T cells was increased slightly in spleen and significantly in the mesenteric lymphnode with the diarrheal symptom (p,0.05). Treatment of cholecalciferol reduced the allergic diarrhea (p,0.05) with the decreasing tendency of CD69 1 CD4 1 T cells, suggesting that the cell population might be associated with the attenuating effect of cholecalciferol on diarrhea occurrence, although immunoglobulin E levels and cytokine productions were not significantly altered by the treatment of cholecalciferol. When given the mice anti-CD69 mAb treatment, significant improvement of allergic diarrhea symptom was observed (p,0.05), accompanying the decrease of CD69 1 CD4 1 T cells which suggested the contribution of these cells to the diarrhea symptom. Taken together, we suggest that administration of cholecalciferol might be useful to suppress symptomatic food allergy in association with the decrease of CD69 1 CD4 1 T cells.

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Vitamin D contributes to mast cell stabilization

Abstract: The data demonstrate that VitD is required to maintain the stability of mast cells. The deficiency of VitD results in mast cell activation.

Cited by 56 publications

References 23 publications

Thermal properties of lignin in copolymers, blends, and composites: a review

Thermal properties of lignin in copolymers, blends, and composites: a review

The Role of Vitamin D in the Immune System as a Pro-survival Molecule

Effect of Cholecalciferol in Food Allergy Mouse Model Is Associated with Decrease of CD69<sup>+</sup> CD4<sup>+</sup> T Cells

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