Vitamin D confers protection to motoneurons and is a prognostic factor of amyotrophic lateral sclerosis

Camu, William; Tremblier, Boris; Plassot, Carine; Alphandéry, Sébastien; Salsac, Céline; Pageot, Nicolas; Juntas-Moralès, Raul; Scamps, Frédérique; Daurès, Jean‐Pierre; Raoul, Cédric

doi:10.1016/j.neurobiolaging.2013.11.005

Cited by 78 publications

(100 citation statements)

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“…Although data relevant to this issue are scarce, factors related to poor bone health, including hyperparathyroidism (33)(34)(35) and vitamin D deficiency (33,34,36,37), may be related to ALS. Correction of hyperparathyroidism did not alter disease course in one study of 5 patients (35), but supplementation with vitamin D delayed the decline in the ALSFRS-R score in some although not all studies (36)(37)(38) and improved motor function in G93A SOD1 transgenic mice (39). A molecular link between bone turnover and ALS may be provided by matrix metalloproteinases (MMPs) and their inhibitors (40).…”

Section: Discussionmentioning

confidence: 99%

Blood Lead, Bone Turnover, and Survival in Amyotrophic Lateral Sclerosis

Fang¹,

Peters²,

Beard³

et al. 2017

American Journal of Epidemiology

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Blood lead and bone turnover may be associated with the risk of amyotrophic lateral sclerosis (ALS). We aimed to assess whether these factors were also associated with time from ALS diagnosis to death through a survival analysis of 145 ALS patients enrolled during 2007 in the National Registry of Veterans with ALS. Associations of survival time with blood lead and plasma biomarkers of bone resorption (C-terminal telopeptides of type I collagen (CTX)) and bone formation (procollagen type I amino-terminal peptide (PINP)) were estimated using Cox models adjusted for age at diagnosis, diagnostic certainty, diagnostic delay, site of onset, and score on the Revised ALS Functional Rating Scale. Hazard ratios were calculated for each doubling of biomarker concentration. Blood lead, plasma CTX, and plasma PINP were mutually adjusted for one another. Increased lead (hazard ratio (HR) = 1.38; 95% confidence interval (CI): 1.03, 1.84) and CTX (HR = 2.03; 95% CI: 1.42, 2.89) were both associated with shorter survival, whereas higher PINP was associated with longer survival (HR = 0.59; 95% CI: 0.42, 0.83), after ALS diagnosis. No interactions were observed between lead or bone turnover and other prognostic indicators. Lead toxicity and bone metabolism may be involved in ALS pathophysiology. amyotrophic lateral sclerosis; blood lead; bone turnover; survival; veterans Abbreviations: ALS, amyotrophic lateral sclerosis; ALSFRS-R, Revised ALS Functional Rating Scale; CI, confidence interval; CTX, C-terminal telopeptides of type I collagen; HR, hazard ratio; MMP, matrix metalloproteinase; PINP, procollagen type I aminoterminal peptide; VA, Veterans Affairs.

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Section: Discussionmentioning

confidence: 99%

Blood Lead, Bone Turnover, and Survival in Amyotrophic Lateral Sclerosis

Fang¹,

Peters²,

Beard³

et al. 2017

American Journal of Epidemiology

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“…Only few previous studies showed similar results [31,32]. In addition, vitamin D deficiency has been also documented in other neurodegenerative diseases, as recently documented in a study conducted by Terracciano et al, focusing myotonic dystrophy type 1 [22].…”

Section: Discussionmentioning

confidence: 68%

Low Serum 25(OH)D Levels in Parkinson Ã¢ÂÂs Disease; a Non Specific Marker of Neurodegeneration?

Olivola¹,

Cerroni²

2015

J Alzheimers Dis Parkinsonism

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Objective: Several investigations have recently inferred that a low serum vitamin D concentration may contribute to cognitive impairment in the elderly. Here, we assessed whether in a cohort of Parkinson's disease (PD) patients attributable to any disease stage a deficit in serum 25-hydroxyvitamin D (25(OH) D) levels occurred as previously proposed and, more importantly, if it is correlated with cognitive impairment or disease duration.Methods: Our PD group (n=54) was compared to an age-matched control group (n= 30), but also to patients afflicted by Alzheimer's disease (AD) (n= 17) and motor neuron disease (amyotrophic lateral sclerosis -ALS) (n=19).Results: Serum 25(OH)D levels > 30 ng/ml was found in 37% of PD patients (versus 76% in controls); in 34 out of 54 PD patients low 25(OH)D levels occurred (28,73 ± 20,22 ng/ml vs 44,52 ± 18,48 ng/ml in control group); however, no correlation with mini mental state examination (MMSE) or disease progression emerged in PD patients. AD cohort was characterized by a significantly lower vitamin D concentration (half manifesting severe deficiency below 10 ng/ml, in contrast with 18% amongst PD). To note, also in ALS, pathological low levels of vitamin D, comparable to PD, was found. Conclusion:Our findings highlight that vitamin D insufficiency or deficiency is shared by multiple neurodegenerative diseases, albeit a-specifically. In PD, 25(OH) D levels do not correlate with cognitive performance. On one hand, these data confirm the opportunity to restore vitamin D levels in a variety of neurological disorders; on the other, they suggest that, in PD, at contrast with AD, vitamin D insufficiency should not play a relevant role in influencing disease severity or unmasking an associated dementia.

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“…cases there is no evidence of any respiratory symptom in the course of the disease (1). A good number of neuromuscular disease starts at younger or later childhood and last over lifetime in adulthood.…”

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confidence: 98%

“…In childhood the most common neuromuscular disorders are Duchenne's muscular dystrophy (DMD) and spinal muscular atrophy. Both conditions start early during childhood, but nowadays last up to the third or even the forth decade of life (1)(2)(3). In adulthood heterogeneous forms of NMD can occur with different progression rate.…”

mentioning

confidence: 99%

“…In adulthood heterogeneous forms of NMD can occur with different progression rate. There are conditions with fast deterioration such as motoneuron diseases (1) and diseases with temporary critical conditions such as in the critical state of myasthenia gravis (2). It is important in terms of quality of life and mortality to assess the muscle weakness and also to define the rate of the progression.…”

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confidence: 99%

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Lung function tests in patients with neuromuscular disorders: how, when and why? Lung function tests in patients with neuromuscular disorders: how, when and why?

Vrdi¹

2014

sob

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SummaryNeuromuscular disorders (NMD) may soon or later affect the lung function according to the clinical progression of any NMD leading often to chronic ventilatory failure. Either the respiratory muscles and the central drive of breathing may be differently involved during the natural history of any different NMD. The evaluation of lung function test should be routinely performed in every NMD patients at least at diagnosis and during follow-up. Also respiratory sleep disturbances and cough efficiency must be carefully checked in every patient with NMD. The present review describes the most useful test to routinely assess lung function in NMD, with particular emphasis on respiratory muscles evaluation. An early assessment of lung function together with use of non invasive home mechanical ventilation may help improved quality of life and prolonged life expectancy.

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Vitamin D confers protection to motoneurons and is a prognostic factor of amyotrophic lateral sclerosis

Cited by 78 publications

References 46 publications

Blood Lead, Bone Turnover, and Survival in Amyotrophic Lateral Sclerosis

Blood Lead, Bone Turnover, and Survival in Amyotrophic Lateral Sclerosis

Low Serum 25(OH)D Levels in Parkinson Ã¢ÂÂs Disease; a Non Specific Marker of Neurodegeneration?

Lung function tests in patients with neuromuscular disorders: how, when and why? Lung function tests in patients with neuromuscular disorders: how, when and why?

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Vitamin D confers protection to motoneurons and is a prognostic factor of amyotrophic lateral sclerosis

Cited by 78 publications

References 46 publications

Blood Lead, Bone Turnover, and Survival in Amyotrophic Lateral Sclerosis

Blood Lead, Bone Turnover, and Survival in Amyotrophic Lateral Sclerosis

Low Serum 25(OH)D Levels in Parkinson Ã¢ÂÂs Disease; a Non Specific Marker of Neurodegeneration?

Lung function tests in patients with neuromuscular disorders: how, when and why? Lung function tests in patients with neuromuscular disorders: how, when and why?

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Product

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Low Serum 25(OH)D Levels in Parkinson Ã¢ÂÂs Disease; a Non Specific Marker of Neurodegeneration?