Vitamin D can safely reduce asthma exacerbations among corticosteroid-using children and adults with asthma: a systematic review and meta-analysis of randomized controlled trials

Chen, Ziyu; Chen, Peng; Mei, Jinyu; Lifa, Zhu,; Kong, Hua

doi:10.1016/j.nutres.2021.05.010

Cited by 18 publications

(10 citation statements)

References 40 publications

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“…However, one study by Chen et al . showed that vitamin D did not improve asthma control test (ACT) score nor lung function among asthmatic patients treated with corticosteroids [ 17 ]. In another observation that was presented in a cross-sectional analysis, Rafiq et al .…”

Section: Vitamin D and Asthmamentioning

confidence: 99%

Recent advances in vitamin D implications in chronic respiratory diseases

et al. 2022

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Chronic airway inflammatory and infectious respiratory diseases are the most common medical respiratory conditions, associated with significant morbidity and mortality. Vitamin D (1,25(OH)2D3) deficiency has been shown to be highly prevalent in patients with chronic airway inflammatory and infectious diseases, correlated with increased disease severity. It has been established that vitamin D modulates ongoing abnormal immune responses in chronic respiratory diseases and is shown to restrict bacterial and viral colonization into the lungs. On the contrary, other studies revealed controversy findings regarding vitamin D efficacy in respiratory diseases. This review aims to update the current evidence regarding the role of vitamin D in airway inflammation and in various respiratory diseases. A comprehensive search of the last five years of literature was conducted using MEDLINE and non-MEDLINE PubMed databases, Ovid MEDLINE, SCOPUS-Elsevier, and data from in vitro and in vivo experiments, including clinical studies. This review highlights the importance of understanding the full range of implications that vitamin D may have on lung inflammation, infection, and disease severity in the context of chronic respiratory diseases.

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Section: Vitamin D and Asthmamentioning

confidence: 99%

Recent advances in vitamin D implications in chronic respiratory diseases

et al. 2022

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“…A meta-analysis published in 2021 [46] showed that treatment with vitamin D significantly reduced the risk of asthma exacerbation (RR 0.70, 95% CI 0.59-0.83; p < 0.05), although no improvement in asthma control or lung function was observed.…”

Section: Vitamin D Deficiency and Asthmamentioning

confidence: 99%

Calcifediol for Use in Treatment of Respiratory Disease

et al. 2022

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Calcifediol is the prohormone of the vitamin D endocrine system (VDES). It requires hydroxylation to move to 1,25(OH)2D3 or calcitriol, the active form that exerts its functions by activating the vitamin D receptor (VDR) that is expressed in many organs, including the lungs. Due to its rapid oral absorption and because it does not require first hepatic hydroxylation, it is a good option to replace the prevalent deficiency of vitamin D (25 hydroxyvitamin D; 25OHD), to which patients with respiratory pathologies are no strangers. Correcting 25OHD deficiency can decrease the risk of upper respiratory infections and thus improve asthma and COPD control. The same happens with other respiratory pathologies and, in particular, COVID-19. Calcifediol may be a good option for raising 25OHD serum levels quickly because the profile of inflammatory cytokines exhibited by patients with inflammatory respiratory diseases, such as asthma, COPD or COVID-19, can increase the degradation of the active metabolites of the VDES. The aim of this narrative revision is to report the current evidence on the role of calcifediol in main respiratory diseases. In conclusion, good 25OHD status may have beneficial effects on the clinical course of respiratory diseases, including COVID-19. This hypothesis should be confirmed in large, randomized trials. Otherwise, a rapid correction of 25(OH)D deficiency can be useful for patients with respiratory disease.

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“… 3 That finding is in keeping with those of other systematic reviews and meta-analyses, although such supplementation was not found to result in an improvement in lung function. 4 , 5 …”

Section: How Does the Well-orchestrated Set Of Responses To Vitamin D...mentioning

confidence: 99%

“…One of the hypotheses raised to explain the lower number of exacerbations among individuals with asthma who receive vitamin D supplementation is that low levels of vitamin D predispose to viral infections, one of the main triggers of asthma exacerbations. 4 A comparison across studies indicates that there is statistical heterogeneity between clinical and functional outcomes. That could be attributed to several factors, including the serum vitamin D level at baseline, dose of vitamin D prescribed, and duration of supplementation; the age of the patients in the sample; latitude; sample variability; bias risk and control; follow-up time; and the use of medications, including oral corticosteroids, which are responsible for reducing serum vitamin D levels.…”

Section: How Does the Well-orchestrated Set Of Responses To Vitamin D...mentioning

confidence: 99%