Vitamin D (Calcifediol) Supplementation Modulates NGF and BDNF and Improves Memory Function in Postmenopausal Women: a Pilot Study

Pozzi, F.; Aloe, Luigi; Frajese, Giovanni Vanni; Frajese, Gaetano

doi:10.5171/2013.552758

Cited by 9 publications

(6 citation statements)

References 48 publications

(10 reference statements)

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“…In the current study, vitamin D administrations also reduced BDNF concentrations in ND + vitamin D group. Same as our results, in a study by Pozzi et al [ 27 ] vitamin D supplementation, diminished BDNF expression and its plasma concentrations in postmenopausal women. In other study, consistently, vitamin D administrations decreased exercise-induced BDNF in rat hippocampus and abolished the BDNF downstream signal transduction cascade important for learning and memory.…”

Section: Discussionsupporting

confidence: 91%

“…In other study, consistently, vitamin D administrations decreased exercise-induced BDNF in rat hippocampus and abolished the BDNF downstream signal transduction cascade important for learning and memory. The authors suggested that BDNF is a vitamin D receptor (VDR) regulated protein affected by VDR suppression; this results can be explained by the fact that vitamin D supplementation in this issue plays a crucial role in the modulation of BDNF in a compensatory mechanism [ 27 , 54 – 56 ].…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D classically is known as a steroid hormone responsible in regulating calcium homeostasis, in addition, it can also involve in brain functions because of its capability in passing through blood brain barrier (BBB) and acting on CNS via its receptors. Vitamin D can preserve cognition including attention, memory orientation, executive function [ 27 , 28 ] and inhibits brain dysfunction in disease models of multiple sclerosis [ 29 ] and AD [ 30 ]. It also acts as an anti-inflammatory, antioxidant and neuro-protective steroid hormone [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

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The effects of vitamin D administration on brain inflammatory markers in high fat diet induced obese rats

et al. 2017

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BackgroundObesity induced brain inflammation is associated with cognitive disorders. We aimed to investigate the influence of vitamin D on hypothalamus and hippocampus inflammatory response in high-fat diet induced obese rats.MethodsIn the beginning of the study, 40 rats were divided into two groups: control diet and high fat diet (HFD) for 16 weeks; then each group subdivided into two groups including: N, ND + vitamin D, HFD and HFD + vitamin D. Vitamin D supplementation was done for 5 weeks at 500 IU/kg dosage. IL-6, IL-1β, NF-Kβ and acetylcholine (ACH) and brain derived neurotropic factor (BDNF) concentrations in hippocampus and hypothalamus homogenate samples were measured by commercial ELISA kits.ResultsVitamin D administration, reduced food intake and weight gain in studied groups (P < 0.001). Vitamin D reduced hippocampus acetylcholine concentrations in ND + vitamin D group (P < 0.001). High fat diet increased hippocampus IL-6 concentrations significantly (P < 0.05) compared with normal diet receiving groups. Vitamin D could not have significant effects on IL-6 concentrations. Vitamin D administrations reduced IL-1β, NF-Kβ and acetylcholine concentration and BDNF concentrations in ND + vitamin D compared with ND group. These reductions were not significant in HFD + vitamin D versus HFD group.ConclusionAccording to our results, vitamin D reduced food intake and weight gain and modulated the HFD induced inflammatory response in hippocampus and hypothalamus of high fat diet induced obesity. Therefore, this neurosteroid, can be suggested as a supplemental therapeutic tool in prevention of obesity related cognitive and neurodegenerative problems.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effects of vitamin D administration on brain inflammatory markers in high fat diet induced obese rats

et al. 2017

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“…Abnormal levels of several neurotrophic factors such as nerve growth factor (NGF) and brain-derived neurotrophic factors (BDNF) have been reported in subset of individuals with ASD [ 175 , 176 ]. Vitamin D analogues have been shown to upregulate NGF in cultured glial cell and embryonic hippocampal cells [ 177 , 178 ], to decrease the percentage of cultured hippocampal cells undergoing mitosis [ 178 ], and to decrease BDNF and concommitantly to improve memory in postmenopausal women [ 179 ].…”

Section: Mechanistic Pathwaysmentioning

confidence: 99%

Vitamin D and Autism Spectrum Disorder: A Literature Review

et al. 2016

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Low vitamin D status in early development has been hypothesised as an environmental risk factor for Autism Spectrum Disorder (ASD), given the concurrent increase in the prevalence of these two conditions, and the association of vitamin D with many ASD-associated medical conditions. Identification of vitamin D-ASD factors may provide indications for primary and secondary prevention interventions. We systematically reviewed the literature for studies on vitamin D-ASD relationship, including potential mechanistic pathways. We identified seven specific areas, including: latitude, season of conception/birth, maternal migration/ethnicity, vitamin D status of mothers and ASD patients, and vitamin D intervention to prevent and treat ASD. Due to differences in the methodological procedures and inconsistent results, drawing conclusions from the first three areas is difficult. Using a more direct measure of vitamin D status—that is, serum 25(OH)D level during pregnancy or childhood—we found growing evidence for a relationship between vitamin D and ASD. These findings are supported by convincing evidence from experimental studies investigating the mechanistic pathways. However, with few primary and secondary prevention intervention trials, this relationship cannot be determined, unless randomised placebo-controlled trials of vitamin D as a preventive or disease-modifying measure in ASD patients are available.

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“…Additionally, vitamin D may stimulate the production of neurotrophins, such as Nerve Growth Factor (NGF) and Glial cell-derived Neurotrophic factor (GDNF) [ 33 , 34 ], which are proteins involved in neuronal development and function [ 35 ]. Vitamin D is shown to increase NGF levels in animals [ 33 ], in-vitro [ 36 ] and in human studies [ 37 ], and specifically in children with ASD [ 38 ]. A very potent increase of GDNF in-vitro studies suggests the in-vivo regulation of GDNF [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Vitamin D Supplementation in Children with Autism Spectrum Disorder: A Narrative Review

et al. 2021

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Children with autism spectrum disorder (ASD) present with persistent deficits in both social communication and interactions, along with the presence of restricted and repetitive behaviors, resulting in significant impairment in significant areas of functioning. Children with ASD consistently reported significantly lower vitamin D levels than typically developing children. Moreover, vitamin D deficiency was found to be strongly correlated with ASD severity. Theoretically, vitamin D can affect neurodevelopment in children with ASD through its anti-inflammatory properties, stimulating the production of neurotrophins, decreasing the risk of seizures, and regulating glutathione and serotonin levels. A Title/Abstract specific search for publications on Vitamin D supplementation trials up to June 2021 was performed using two databases: PubMed and Cochrane Library. Twelve experimental studies were included in the synthesis of this review. Children with ASD reported a high prevalence of vitamin D deficiency or insufficiency. In general, it was observed that improved vitamin D status significantly reduced the ASD severity, however, this effect was not consistently different between the treatment and control groups. The variations in vitamin D dose protocols and the presence of concurrent interventions might provide an explanation for the variability of results. The age of the child for introducing vitamin D intervention was identified as a possible factor determining the effectiveness of the treatment. Common limitations included a small number of participants and a short duration of follow-ups in the selected studies. Long-term, well-designed randomized controlled trials are warranted to confirm the effect of vitamin D on severity in children with ASD.

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Vitamin D (Calcifediol) Supplementation Modulates NGF and BDNF and Improves Memory Function in Postmenopausal Women: a Pilot Study

Cited by 9 publications

References 48 publications

The effects of vitamin D administration on brain inflammatory markers in high fat diet induced obese rats

The effects of vitamin D administration on brain inflammatory markers in high fat diet induced obese rats

Vitamin D and Autism Spectrum Disorder: A Literature Review

The Role of Vitamin D Supplementation in Children with Autism Spectrum Disorder: A Narrative Review

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