Vitamin D-Binding Protein

Hurwitz, Ivy; Cooke, Nancy E.

doi:10.1016/b0-12-341103-3/00305-3

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…The KAM typically exhibits two peaks during the stance phase of walking, which correspond to the peaks in the vertical GRF [6]. Of these, the first peak has been shown to be higher in TFOA patients [7][8][9] and has been proposed to be the more important loading variable to reduce [10].…”

Section: Introductionmentioning

confidence: 99%

Real-Time Knee Adduction Moment Feedback for Gait Retraining Through Visual and Tactile Displays

Wheeler

Shull

Besier

2011

Journal of Biomechanical Engineering

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The external knee adduction moment (KAM) measured during gait is an indicator of tibiofemoral joint osteoarthritis progression and various strategies have been proposed to lower it. Gait retraining has been shown to be an effective, noninvasive approach for lowering the KAM. We present a new gait retraining approach in which the KAM is fed back to subjects in real-time during ambulation. A study was conducted in which 16 healthy subjects learned to alter gait patterns to lower the KAM through visual or tactile (vibration) feedback. Participants converged on a comfortable gait in just a few minutes by using the feedback to iterate on various kinematic modifications. All subjects adopted altered gait patterns with lower KAM compared with normal ambulation (average reduction of 20.7%). Tactile and visual feedbacks were equally effective for real-time training, although subjects using tactile feedback took longer to converge on an acceptable gait. This study shows that real-time feedback of the KAM can greatly increase the effectiveness and efficiency of subject-specific gait retraining compared with conventional methods.

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Section: Introductionmentioning

confidence: 99%

Real-Time Knee Adduction Moment Feedback for Gait Retraining Through Visual and Tactile Displays

Wheeler

Shull

Besier

2011

Journal of Biomechanical Engineering

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Alterations in Mineral Metabolism in the Aging Male

Misra

Silverberg

2010

Osteoporosis in Men

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Vitamin D Receptor (VDR) Regulation of Voltage-Gated Chloride Channels by Ligands Preferring a VDR-Alternative Pocket (VDR-AP)

Menegaz

Mizwicki

Barrientos‐Durán

et al. 2011

Molecular Endocrinology

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We have postulated that the vitamin D receptor (VDR) contains two overlapping ligand binding sites, a genomic pocket and an alternative pocket (AP), that mediate regulation of gene transcription and rapid responses, respectively. Flexible VDR + ligand docking calculations predict that the major blood metabolite, 25(OH)-vitamin D(3) (25D3), and curcumin (CM) bind more selectively to the VDR-AP when compared with the seco-steroid hormone 1α,25(OH)(2)-vitamin D(3) (1,25D3). In VDR wild-type-transfected COS-1 cells and TM4 Sertoli cells, 1,25D3, 25D3, and CM each trigger voltage-gated, outwardly rectifying chloride channel (ORCC) currents that can be blocked by the VDR antagonist 1β,25(OH)(2)-vitamin D(3) and the chloride channel antagonist (4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid). VDR mutational analysis in transfected COS-1 cells demonstrate the DNA-binding domain is not, but the ligand binding and hinge domains of the VDR are, required for 1,25D3 and 25D3 to activate the ORCC. Dose-response studies demonstrate that 25D3 and 1,25D3 are approximately equipotent in stimulating ORCC rapid responses, whereas 1 nm 1,25D3 was 1000-fold more potent than 25D3 and CM in stimulating gene expression. The VDR-AP agonist effects of 1,25D3, 25D3, and low-dose CM are lost after pretreatment of TM4 cells with VDR small interfering RNA. Collectively, these results are consistent with an essential role for the VDR-AP in initiating the signaling required for rapid opening of ORCC. The fact that 25D3 is equipotent to 1,25D3 in opening ORCC suggests that reconsideration of the ability of 25D3 to generate biological responses in vivo may be in order.

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Vitamin D-Binding Protein

Cited by 4 publications

References 13 publications

Real-Time Knee Adduction Moment Feedback for Gait Retraining Through Visual and Tactile Displays

Real-Time Knee Adduction Moment Feedback for Gait Retraining Through Visual and Tactile Displays

Alterations in Mineral Metabolism in the Aging Male

Vitamin D Receptor (VDR) Regulation of Voltage-Gated Chloride Channels by Ligands Preferring a VDR-Alternative Pocket (VDR-AP)

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