Vitamin D associated inflammation and atherosclerosis

Munisamy, Seetha; Mokhtar, Sitisafiah; Hou, Low Jen; Lee, Wee Chee; Rasool, Aida Hanum Ghulam

doi:10.4314/tjpr.v20i7.30

Cited by 2 publications

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“…In patients with type 2 diabetes, vitamin D 3 can inhibit macrophage cholesterol intake by decreasing CD36 expression. Furthermore, vitamin D controls endoplasmic reticulum stress to create an antiatherogenic monocyte phenotype, therefore reducing inflammation and vascular complications 53 .…”

Section: Discussionmentioning

confidence: 99%

Non‐classical monocytes frequency and serum vitamin D₃ levels are linked to diabetic foot ulcer associated with peripheral artery disease

Hammad

Wahab

Farouk

et al. 2023

J of Diabetes Invest

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Aims/IntroductionPeripheral artery disease (PAD) serves as a risk factor for diabetic foot ulcers (DFUs). PAD pathology involves atherosclerosis and impaired immunity. Non‐classical monocytes are believed to have an anti‐inflammatory role. 1,25‐Dihydroxy vitamin D (vitamin D3) is claimed to have immune‐modulating and lipid‐regulating roles. Vitamin D receptor is expressed on monocytes. We aimed to investigate if circulating non‐classical monocytes and vitamin D3 were implicated in DFUs associated with PAD.Materials and MethodsThere were two groups of DFU patients: group 1 (n = 40) included patients with first‐degree DFUs not associated with PAD, and group 2 (n = 50) included patients with DFU with PAD. The monocyte phenotypes were detected using flow cytometry. Vitamin D3 was assessed by enzyme‐linked immunosorbent assay.ResultsDFU patients with PAD showed a significant reduction in the frequency of non‐classical monocytes and vitamin D3 levels, when compared with DFU patients without PAD. The percentage of non‐classical monocytes positively correlated with vitamin D3 level (r = 0.4, P < 0.01) and high‐density lipoprotein (r = 0.5, P < 0.001), whereas it was negatively correlated with cholesterol (r = −0.5, P < 0.001). Vitamin D3 was negatively correlated with triglyceride/high‐density lipoprotein (r = −0.4, P < 0.01). Regression analysis showed that a high vitamin D3 serum level was a protective factor against PAD occurrence.ConclusionsNon‐classical monocytes frequency and vitamin D3 levels were significantly reduced in DFU patients with PAD. Non‐classical monocytes frequency was associated with vitamin D3 in DFUs patients, and both parameters were linked to lipid profile. Vitamin D3 upregulation was a risk‐reducing factor for PAD occurrence.

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Section: Discussionmentioning

confidence: 99%

Non‐classical monocytes frequency and serum vitamin D₃ levels are linked to diabetic foot ulcer associated with peripheral artery disease

Hammad

Wahab

Farouk

et al. 2023

J of Diabetes Invest

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show abstract

“…In addition to its role in bone and mineral metabolism, vitamin D has been reported to be involved in both cardiovascular and immunological processes, including cytokine expression, vascular cell differentiation, proliferation, migration, immune response organisation, and all steps of endothelial activation and dysfunction [8]. Large-scale epidemiological studies have associated vitamin D deficiency with increased cardiovascular risk due to accelerated atherosclerosis [9][10][11]. Vitamin D deficiency was observed in a high proportion of patients with myocardial infarction [12].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D mitigates atherosclerosis risk in TNF-α-induced endothelial cells

Önal¹,

Alaylıoğlu²,

Dursun³

et al. 2022

Trop. J. Pharm Res

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Purpose: To determine the effect of vitamin D on endothelial function in a cell line model of inflammation.Methods: Human saphenous vein cells were treated with 1,25-dihydroxyvitamin D3 (1,25-OHD) and/or TNF-α, and the expression levels of 20 different atherosclerotic cytokines were examined in the treated cells using a human atherosclerosis antibody array. The STRING and PANTHER analyses were also performed to determine the possible pathway interactions of these four pro-atherosclerotic and two antiatherosclerotic cytokines.Results: The expression levels of pro-atherosclerotic cytokines GM-CSF, CCL20, CCL5, and TNF-α decreased upon 1,25-OHD administration, whereas those of anti-atherosclerotic cytokines PDGFB and TGF-β3 increased.Conclusion: Vitamin D could mitigate cardiovascular risks by mediating the expression of inflammatory cytokines; however, this needs to be verified via in vivo studies.

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Vitamin D associated inflammation and atherosclerosis

Cited by 2 publications

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Non‐classical monocytes frequency and serum vitamin D₃ levels are linked to diabetic foot ulcer associated with peripheral artery disease

Non‐classical monocytes frequency and serum vitamin D₃ levels are linked to diabetic foot ulcer associated with peripheral artery disease

Vitamin D mitigates atherosclerosis risk in TNF-α-induced endothelial cells

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Vitamin D associated inflammation and atherosclerosis

Cited by 2 publications

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Non‐classical monocytes frequency and serum vitamin D3 levels are linked to diabetic foot ulcer associated with peripheral artery disease

Non‐classical monocytes frequency and serum vitamin D3 levels are linked to diabetic foot ulcer associated with peripheral artery disease

Vitamin D mitigates atherosclerosis risk in TNF-α-induced endothelial cells

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Non‐classical monocytes frequency and serum vitamin D₃ levels are linked to diabetic foot ulcer associated with peripheral artery disease

Non‐classical monocytes frequency and serum vitamin D₃ levels are linked to diabetic foot ulcer associated with peripheral artery disease