Vitamin D assessment in perioperative medicine and critical care

Zajic, Paul; Heschl, Stefan; Schörghuber, Michael; Srekl-Filzmaier, P; Stojaković, Tatjana; Weixler, Viktoria; Zelzer, Sieglinde; Amrein, Karin

doi:10.1007/s00508-019-01584-x

Cited by 6 publications

(8 citation statements)

References 23 publications

(31 reference statements)

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“…Five studies ( 2 , 18 , 19 , 25 , 31 ) focused on children with congenital heart disease and 11 studies ( 1 , 20 – 24 , 26 – 30 ) were on adults, of which seven studies ( 1 , 22 – 24 , 26 – 28 ) reported patients undergoing coronary artery bypass surgery (CABG). Eleven studies ( 1 , 2 , 18 , 19 , 21 , 23 – 26 , 29 , 31 ) reported a detailed method used to measure the serum concentration of VitD and 10 studies ( 1 , 2 , 18 – 20 , 25 , 26 , 28 , 30 , 31 ) reported a clear definition of VitD deficiency as 25-(OH) VitD <20 ng/ml or <50 nmol/L. About half of the included studies yielded a high risk of a bias and the other half were at low risk according to the NOS ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…Six studies ( 18 , 19 , 25 , 29 – 31 ) provided data on the VitD level preoperatively, immediately after surgery, and 24 h after surgery, and one study ( 21 ) provided data only on the VitD level preoperatively and 24 h after surgery. Furthermore, four studies ( 18 , 19 , 25 , 31 ) reported the VitD level in children with congenital heart disease and three studies ( 21 , 29 , 30 ) were in adults. However, two studies ( 29 , 30 ) did not mention the way to measure the serum 25-(OH)-VitD concentration.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, four studies ( 18 , 19 , 25 , 31 ) reported the VitD level in children with congenital heart disease and three studies ( 21 , 29 , 30 ) were in adults. However, two studies ( 29 , 30 ) did not mention the way to measure the serum 25-(OH)-VitD concentration. Three studies in adults ( 21 , 29 , 30 ) reported on patients who underwent types of cardiac surgery other than CABG.…”

Section: Resultsmentioning

confidence: 99%

“…However, two studies ( 29 , 30 ) did not mention the way to measure the serum 25-(OH)-VitD concentration. Three studies in adults ( 21 , 29 , 30 ) reported on patients who underwent types of cardiac surgery other than CABG.…”

Section: Resultsmentioning

confidence: 99%

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Association Between the Circulating Level of 25-Hydroxyvitamin D and Clinical Results After Cardiac Surgery: A Meta-Analysis and Systematic Review

Zhang

Qiu

et al. 2021

Front. Cardiovasc. Med.

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Background: Vitamin D (VitD) is an important pleiotropic hormone for organ systems. Studies have focused on the level of VitD, especially that of 25-hydroxyvitamin D (25-(OH)-VitD), in patients after cardiac surgery and the relationship between VitD deficiency and adverse outcomes, but the results have been inconsistent. We carried out a meta-analysis to evaluate differences in the 25-(OH)-VitD level before and after cardiac surgery, and evaluated the predictive value of 25-(OH)-VitD level in the clinical outcomes of patients undergoing cardiac surgery.Methods: Studies related to VitD level and cardiac surgery were searched from PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials databases from inception to October 2020. We applied the Newcastle–Ottawa Scale to assess the risk of a bias in individual studies. We examined the heterogeneity and publication bias and performed subgroup analyses and sensitivity analyses.Results: Fifteen studies were included in our analysis. The 25-(OH)-VitD level was significantly lower immediately after surgery [stand mean difference (SMD), 0.69; 95%CI (0.1, 1.28), P = 0.023] and 24-h after surgery [0.84; (0.47, 1.21), 0.000] compared with that before surgery. A higher prevalence of 25-(OH)-VitD deficiency was recorded 24 h after surgery [RR, 0.59; 95%CI (0.47, 0.73), P = 0.00]. Pooled results demonstrated a significant relationship between the preoperative 25-(OH)-VitD level and vasoactive-inotropic score (VIS) [SMD, −3.71; 95%CI (−6.32, −1.10); P = 0.005], and patients with 25-(OH)-VitD deficiency revealed a comparatively poor prognosis and severe condition after cardiac surgery [−0.80; (−1.41, −0.19), 0.01]. However, 25-(OH)-VitD deficiency was not associated with the duration of stay in the intensive care unit.Conclusions: Cardiac surgery would leads to deficiency of 25-(OH)-VitD. And the preoperative and postoperative levels of 25-(OH)-VitD are associated with adverse events, which is eligible to work as an indicator to demonstrate clinical outcomes.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Association Between the Circulating Level of 25-Hydroxyvitamin D and Clinical Results After Cardiac Surgery: A Meta-Analysis and Systematic Review

Zhang

Qiu

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…We would like to stress that clinicians administering vitamin D should be aware of the factors that may contribute to acute changes in vitamin D levels [10]. Both for changes in volume distribution and for cartridge absorption and filtration, the level of vitamin D is lower in critically ill patients on CRRT, and the same can be hypothesized in the case of supplementation [11].…”

Section: Authors' Responsementioning

confidence: 99%