Vitamin D as potential antidepressant in outpatients with musculoskeletal pain

Abdul‐Razzak, Khalid K.; Mayyas, Fadia; Al-Farras, Mudhaffar I.

doi:10.5414/cp203252

Cited by 8 publications

(47 citation statements)

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“…In the current study, vitamin D supplementation plus increased dairy products intake resulted in significant reduction in MSP severity, which was accompanied by significant improvements in self‐reported fatigue among psychiatric outpatients. Similar findings were also observed previously …”

Section: Discussionsupporting

confidence: 93%

“…The control group included subjects who were apparently healthy, without OAB symptoms, MSP, fatigue or sleep disturbance . Subjects excluded were those with chronic diseases affecting vitamin D metabolism including kidney and liver disease and disability diseases, and conditions damaging nerve (such as diabetes mellitus, stroke, and multiple sclerosis), who are not able to complete the questionnaire, and who were on vitamin D supplements for the last 2 months …”

Section: Methodsmentioning

confidence: 99%

“…All participants were informed about the objectives of the study, agreed to participate, and answered a self‐guided questionnaire, which contained sociodemographic health status, disease conditions, localization, and severity of MSP if present. Pain severity was measured using a 0 to 10 Numerical Rating Scale (NRS) . The patients with OAB answered questions about disease duration and symptoms including daytime urinary frequency, nocturia, enuresis, and UI .…”

Section: Methodsmentioning

confidence: 99%

“…Intake of dairy products was determined on daily basis as none, single, two, and three or more dairy servings per day. A dairy serving is defined as: 1 cup of milk or yogurt (300 mg calcium), 2 full tablespoons (2 oz) of labneh (100 mg calcium), and a 1‐ounce piece of cheese (162 mg calcium), and cream cheese (20 mg calcium) …”

Section: Methodsmentioning

confidence: 99%

“…Previously, we found that low serum vitamin D level and low daily calcium intake were associated with psychological symptoms among patients with MSP, psychiatric outpatients, and those with noncardiac chest pain . Vitamin D supplementation seems to have a positive effect on all of these comorbidities in outpatients with MSP or psychiatric outpatients …”

Section: Introductionmentioning

confidence: 91%

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Overactive bladder and associated psychological symptoms: A possible link to vitamin D and calcium

Abdul‐Razzak

Alshogran

Altawalbeh

et al. 2019

Neurourology and Urodynamics

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Introduction Overactive bladder (OAB) is a prevalent syndrome that is associated with multiple urinary tract symptoms and could affect the patient's quality of life and well‐being. Vitamin D is shown to be linked to OAB syndrome, which exacerbated by stress conditions. This study evaluated the relationship between vitamin D status, daily calcium intake and OAB, and the associated psychological symptoms. Methods The study included 55 patients with OAB and 129 healthy controls. Psychological symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS). Serum vitamin D was measured. Patients with OAB with low vitamin D level received orally vitamin D supplementation. Urinary symptoms, psychological symptoms, and quality of life were evaluated before and after vitamin D supplementation plus dairy products. Results Vitamin D deficiency was more prevalent in cases (80%) vs controls (34.9%). Depression (43.7% vs 20.2%) and anxiety (52.8% vs 10.9%) scores (HADS, ≥8) were also more frequent in cases vs controls, respectively. Some 85.5% of the patients’ group had musculoskeletal pain vs 0.0% for the control. Depression was negatively correlated with daily calcium intake and positively with anxiety. Logistic regression analysis revealed that age, vitamin D, and anxiety scores were significant predictors of OAB. Vitamin D supplements with increased calcium intake had significant improvement in urinary symptoms, psychological distress, and quality of life. Conclusions Vitamin D supplements and improved calcium intake may improve urinary and psychological symptoms and quality of life among patients with OAB syndrome. Assessment for vitamin D status in patients with OAB may be warranted.

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Section: Discussionsupporting

confidence: 93%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

See 3 more Smart Citations

Overactive bladder and associated psychological symptoms: A possible link to vitamin D and calcium

Abdul‐Razzak

Alshogran

Altawalbeh

et al. 2019

Neurourology and Urodynamics

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Association of asthma with low serum vitamin D and its related musculoskeletal and psychological symptoms in adults: a case-control study

Alkhatatbeh

Almomani

Abdul‐Razzak

et al. 2021

npj Prim. Care Respir. Med.

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There are complex potential inter-relationships between the chronic inflammation of asthma and poor control, vitamin D deficiency, musculoskeletal pain and anxiety and depression. The aim was to investigate associations between vitamin D and these possible co-morbidities. This case-controlled study involved 75 adults with asthma and 75 controls. Serum 25-hydroxyvitamin D (25(OH)D) was measured, levels of anxiety, depression, musculoskeletal pain, and asthma control were assessed. Participants with asthma had lower 25(OH)D and higher anxiety scores and higher measures of musculoskeletal pain compared to controls. Binary logistic regression showed that asthma was associated with decreased 25(OH)D (Odds ratio (OR) = 0.86), general weakness (OR = 13.29), complaint of musculoskeletal pain (OR = 13.73), and increased intensity of musculoskeletal pain (OR = 0.61) and number of painful sites (OR = 2.58). Asthma was not associated with anxiety or depression. Further studies are required to investigate if vitamin D supplementation can improve asthma symptoms and musculoskeletal pain.

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Exercise, nutrition, and medication considerations in the light of the COVID pandemic, with specific focus on geriatric population: A literature review

Yang

Chou

Kao

2020

Journal of the Chinese Medical Association

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The pandemic of severe acute respiratory syndrome coronavirus 2 has spread across the world, causing causalities and inflicting chronic complications in those who survive the infection. Disruptions in the immune system and lowered physical levels caused by quarantine protocols are the major causes of chronic dysfunction and impaired life independency, especially in elderly patients. Multiple exercise suggestions and novel program delivery methods, including telerehabilitation/tele-exercise programs, home-gym strategies, and exergames, have emerged. Patients with underlying obesity, diabetes mellitus, malnutrition, or binge-eating problems are at a high risk of serious infection and sequela. Adequate education and coping strategies can lessen the potential infection complications and improve the quality of life. Acknowledging the possible benefits and risks of nonsteroidal anti-inflammatory drug usage in chronic pain patients, and the supplementation of vitamin D may also aid in treating post-infected patients.

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Vitamin D as potential antidepressant in outpatients with musculoskeletal pain

Abstract: Low serum vitamin D is associated with MSP along with low calcium intake, depression, and anxiety. Supplementation with vitamin D improved MSP and associated disorders. .

Cited by 8 publications

References 0 publications

Overactive bladder and associated psychological symptoms: A possible link to vitamin D and calcium

Overactive bladder and associated psychological symptoms: A possible link to vitamin D and calcium

Association of asthma with low serum vitamin D and its related musculoskeletal and psychological symptoms in adults: a case-control study

Exercise, nutrition, and medication considerations in the light of the COVID pandemic, with specific focus on geriatric population: A literature review

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Vitamin D as potential antidepressant in outpatients with musculoskeletal pain

Abstract: Low serum vitamin D is associated with MSP along with low calcium intake, depression, and anxiety. Supplementation with vitamin D improved MSP and associated disorders. .

Cited by 8 publications

References 0 publications

Overactive bladder and associated psychological symptoms: A possible link to vitamin D and calcium

Overactive bladder and associated psychological symptoms: A possible link to vitamin D and calcium

Association of asthma with low serum vitamin D and its related musculoskeletal and psychological symptoms in adults: a case-control study

Exercise, nutrition, and medication considerations in the light of the COVID pandemic, with specific focus on geriatric population: A literature review

Contact Info

Product

Resources

About

Abstract: Low serum vitamin D is associated with MSP along with low calcium intake, depression, and anxiety. Supplementation with vitamin D improved MSP and associated disorders. .