Vitamin D as a Neuroactive Substance: Review

Kiraly, Stephen J.; Király, Michael A.; Hawe, Rick D; Makhani, Naila

doi:10.1100/tsw.2006.25

Cited by 101 publications

(67 citation statements)

References 137 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One study showed that vitamin D potentiates axon regeneration by significantly increasing axogenesis and axon diameter in a rat model of peripheral nerve injury (Chabas et al 2008). Thus vitamin D may have a potential role in the treatment of CNS injuries (Kiraly et al 2006;Cekic et al 2009). …”

Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease

Gezen-Ak

Dursun

Bılgıç

et al. 2012

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Vitamin D 3 is a neurosteroid that mediates its effects via the vitamin D receptor (VDR). The VDR gene is located on chromosome 12q13 and consists of 9 exons. VDR contains the DNA-binding site encoded by exons 2 and 3 and the ligand-binding site encoded by exons 4 -9. Our earlier study showed that the ApaI polymorphic site of the VDR gene is associated with late-onset Alzheimer's disease (AD). Here, we investigated the association between additional polymorphisms of the VDR gene and AD using the same samples. Two single nucleotide polymorphisms (SNPs) in intron 8 (BsmI and Tru9I polymorphisms) and one in exon 2 (FokI polymorphism) of the VDR gene were examined in up to 108 AD patients and 115 age-matched controls. Genotypes were determined with polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. Haplotype analysis also included the previously studied polymorphic sites that were recognized by TaqI (in exon 9) and ApaI (in intron 8) restriction enzymes. There was no significant difference between AD patients and controls when their genotypes for BsmI, Tru9I and FokI polymorphic sites were compared. However, the frequency of "TaubF" haplotype (alleles of TaqI, ApaI, Tru9I, BsmI and FokI, respectively), which was determined by analyzing 5 polymorphisms together, was significantly higher in the AD patient group, suggesting that this haplotype is a risk factor in AD. Our results point out a possible link between AD and certain VDR polymorphisms and indicate that individuals with these polymorphisms might be vulnerable to AD.

show abstract

Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease

Gezen-Ak

Dursun

Bılgıç

et al. 2012

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…2 In addition, vitamin D exerts antithrombotic and neuroprotective effects and was shown to attenuate ischemic cortical injury in rats. 11,12 We acknowledge that our results may be limited because the z values for vitamin D metabolites were based on data from patients referred to coronary angiography and not from a "healthy" control group. With reference to our work and the meta-analysis that found an increased survival in persons treated with vitamin D, we are of the opinion that it is a promising and safe preventive/therapeutic approach to supplement vitamin D in patients after stroke and at high risk for stroke to maintain 25(OH)D concentrations of at least 75 nmol/L (30 ng/mL), which have been shown to be most effective in producing favorable health outcomes.…”

Section: Discussionmentioning

confidence: 99%

Low Vitamin D Levels Predict Stroke in Patients Referred to Coronary Angiography

Pilz

Dobnig²,

Fischer³

et al. 2008

Stroke

253

154

View full text Add to dashboard Cite

Background and Purpose-Vitamin D deficiency is common among the elderly and may contribute to cerebrovascular diseases. We aimed to elucidate whether low vitamin D levels are predictive for fatal stroke. 4 In cross-sectional analyses, hemiplegic patients with acute stroke showed significantly reduced 25(OH)D concentrations compared with healthy controls. 5 Data from a population-based study showed that elderly persons with a low intake of vitamin D and low serum concentrations of 1,25(OH)2D were at increased risk for future strokes even after adjustment for age, sex, smoking, and functional capacity. 6 We aimed to extend the currently rare knowledge about vitamin D and stroke by addressing the question whether low levels of 25(OH)D and 1,25(OH)2D are predictive for fatal stroke in patients from the LURIC study. Methods-The Subjects and MethodsA detailed description of the baseline examinations of the LURIC study has been published elsewhere. 7 In brief, the LURIC study is a prospective cohort study of 3316 white patients who were routinely referred to coronary angiography at a single tertiary center in southwestern Germany. All study participants gave their informed consent, and the ethics committee at the Á rztekammer RheinlandPfalz approved the study. Previous cerebrovascular disease (CVD) events were defined as a documented history of a foregoing transient ischemic attack, prolonged ischemic deficit, or cerebral infarction with or without a remaining neurologic deficit. 7 25(OH)D was determined in serum samples by radioimmunoassay (RIA) (DiaSorin Antony, France; Stillwater, Minn, USA) with an intra-assay and interassay coefficient of variation of 8.6% and 9.2%, respectively. In 100 randomly chosen samples, we determined 25(OH)D by liquid (Tables 2 and 3). These odds ratios remained significant after adjustments for cardiovascular risk factors, physical activity level, and calcium and parathyroid hormone levels (Tables 2 and 3). At baseline, 274 patients had a history of previous CVD events. In age-and sex-adjusted binary logisticregression analyses including the entire LURIC cohort (survivors and all deceased patients), the odds ratios per z value were 0.76 ( DiscussionIn a cohort of Ͼ3000 patients referred to coronary angiography, low levels of 25(OH)D and 1,25(OH)2D were independent predictors for fatal stroke and were reduced in patients with a history of previous CVD events at baseline. In particular, patients after acute stroke are at increased risk for vitamin D insufficiency due to reduced sun exposure and low dietary intake. 8 Vitamin D supplementation in stroke patients has already been shown to reduce osteopenia, fractures, and falls while improving muscle strength. 9,10 Apart from these beneficial effects, our results suggest that vitamin D might also directly protect against stroke. This hypothesis is supported by data indicating that vitamin D may protect against hypertension, diabetes mellitus, and atherosclerosis. 2 In addition, vitamin D exerts antithrombotic and neuroprotective effects ...

show abstract

“…Furthermore, people with vitamin D deficiency have higher risk of developing schizophrenia (Kiraly et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Vitamin D Deficiency Among Patients With Schizophrenia in Duhok City

Mohamed

Haji

2016

SJUOZ

View full text Add to dashboard Cite

Abstract:The current cross sectional study, it was aimed to estimate the prevalence of Vitamin D deficiency among 110 patients with schizophrenia in Duhok city, who attended the psychiatric Clinic and Department of Azadi teaching hospital. Their total vitamin D level was measured and the result indicated that vitamin D is below the normal level in more than 76% and deficient in 47%. Statistical analysis of the results showed the presence of a significant difference in incidences between male and female and there were significant increase with the duration of the disease. From the results of the present study concluded that vitamin D deficiency is common in this group of population and most of them were not screened or treated. Keyword:Introduction:

show abstract

Vitamin D as a Neuroactive Substance: Review

Cited by 101 publications

References 137 publications

Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease

Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease

Low Vitamin D Levels Predict Stroke in Patients Referred to Coronary Angiography

The Prevalence of Vitamin D Deficiency Among Patients With Schizophrenia in Duhok City

Contact Info

Product

Resources

About