Vitamin D and wound healing: Assessing skin barrier function and implications for chloasma treatment

Abstract

Chloasma, which is distinguished by irregularities in the pigmentation of skin, poses substantial challenge in the field of dermatology. The regulatory influence of vitamin D on the functions of skin cells implies that it may have the capacity to effectively treat chloasma and promote wound healing. To assess the efficacy of vitamin D in chloasma treatment and its impact on the function of skin barrier during the process of wound healing. The research spanned from April 2022 to September 2023, in Shanghai, China, examined 480 individuals who had been diagnosed with chloasma. A double‐blind, placebo‐controlled clinical trial was utilized to evaluate effectiveness of topical vitamin D3 in treatment of chloasma. Concurrently, randomized control trial investigated the effects of ingested vitamin D3 supplements on the process of wound healing. Transepidermal water loss (TEWL), chloasma severity score changes, wound size reduction and skin hydration levels were critical performance indicators. Statistically, the severity scores of chloasma decreased significantly in the vitamin D treatment group at 3 and 6 months compared with the placebo (p < 0.05). The Vitamin D group exhibited superior wound healing outcomes, including more substantial reduction in lesion size and enhanced skin barrier function, as evidenced by increased skin hydration and decreased TEWL (p < 0.05). Vitamin D substantially mitigated the severity of chloasma and has beneficial effect on wound healing and integrity of the skin barrier. Based on the results obtained, vitamin D exhibited promise as a therapeutic intervention in the field of dermatology, specifically in treatment of chloasma and promotion of wound recovery.

Exploring Skin Wound Healing Models and the Impact of Natural Lipids on the Healing Process

“…We observed that physiological concentrations of 1,25(OH) 2 D 3 stimulate keratinocyte proliferation, while higher doses inhibit growth. Recently, the Zhang laboratory conducted a clinical trial demonstrating the efficacy of topical vitamin D 3 in treating chloasma, a condition of hypermelanosis occurring during pregnancy, as well as in enhancing wound healing outcomes [28]. In another study, the Watsky laboratory found that both topical 1,25(OH) 2 D 3 and 24,25(OH) 2 D 3 accelerate corneal wound healing in mice [29].…”