Vitamin D and Vitamin D Dependency

Tsuchiya, Yutaka; Matsuo, Nobutake; Cho, Hideo; Tsubouchi, Kofi; Kumagai, Michio; Nishii, Yasuho; Nanjoh, Masaki; Yamamoto, Tetsuya

doi:10.1159/000385991

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“…They interpreted the results as suggesting that in vitamin D dependency, hyporesponsiveness of the target organs to biologically active vitamin D appeared unlikely and conversion of native vitamin D to25(OH) vitamin D was not disturbed, but a block was present in subsequent conversion to 1.25(OH)2vitamin D. Their interpretation is not confirmed in vitro enzymatic study, but effectiveness of small doses of1.25(011)2 vitamin D3 or1(OH) vitamin D3in vitamin D dependency was confirmed by other investigators (Reade et al, 1975) (Balsan et al, 1975) (Prader et al, 1976) (Tsuchiya et al, 1976)(Cho et al, 1977.…”

Section: Discussionmentioning

confidence: 94%

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Biological Activity of1-alpha-hydroxy Vitamin D<SUB>3</SUB>in Vitamin D Dependency

et al. 1979

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The biological activity of1(OH) vitamin D3was evaluated in2cases of vitamin D dependency.For the improvement of serum chemistry and increment of urinary excretion of calcium1 (OH) vitamin D3was500-1000times more active than vitamin D2. The administration of0.05microg/kg/day and0.1microg/kg/day of1(OH) vitamin D3were equally effective to keep the serum chemistry within normal limits. However, urinary excretion of calcium increased to an abnormal height on0.1microg/ kg/day of1(OH) vitamin D3. On the other hand, administration of0.05microg/kg/ day of1(OH) vitamin D3kept both serum level and urinary excretion of calcium normal.It is suggested that0.05microg/kg/day is close to the optimum requirement of 1(OH) vitamin D3in vitamin D dependency and this should correspond to the essential requirement of1(OH) vitamin D3in man.

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Section: Discussionmentioning

confidence: 94%

“…It is thought that in vitamin D dependency conversion of25(OH) vitamin D to1.25(OH)2vitamin D was disturbed (Fraser et al, 1973 (Reade et al, 1975, Balsan et al, 1975, Tsuchiya et al, 1976, Cho et al, 1977.…”

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confidence: 99%