Vitamin D and vascular calcification

Zittermann, Armin; Schleithoff, Stefanie Schulze; Koerfer, Reiner

doi:10.1097/mol.0b013e328011c6fc

Cited by 174 publications

(118 citation statements)

References 48 publications

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“…In addition to possible direct effects due to the presence of the vitamin D receptor (VDR) and of the 1-alpha hydroxylase enzyme in cardiomyocytes and other cells of the cardiovascular system [16], vitamin D has significant effects on several cardiovascular risk factors. Studies, ranging from animal trials to RCTs, have shown that vitamin D reduces inflammation [17], controls several matrix metalloproteinases (MMPs) involved in vascular calcification [18], improves endothelial function [19], controls the secretion of insulin and improves insulin sensitivity [20;21], and decreases parathyroid hormone (PTH) secretion [22].…”

Section: Effects Of Vitamin D On the Cardiac Systemmentioning

confidence: 99%

Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice

Souberbielle¹,

Body

Lappe

et al. 2010

Autoimmunity Reviews

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491

375

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Background: There is increasing evidence that, in addition to the well-known effects on musculoskeletal health, vitamin D status may be related to a number of non-skeletal diseases.An international expert panel formulated recommendations on vitamin D for clinical practice, taking into consideration the best evidence available based on published literature today. In addition, where data were limited to smaller clinical trials or epidemiologic studies, the panel made expert-opinion based recommendations.Methods: Twenty-five experts from various disciplines (classical clinical applications, cardiology, autoimmunity, and cancer) established draft recommendations during a 2-day meeting. Thereafter, representatives of all disciplines refined the recommendations and related texts, subsequently reviewed by all panelists. For all recommendations, panelists expressed the extent of agreement using a 5-point scale. Results and conclusion:Recommendations were restricted to clinical practice and concern adult patients with or at risk for fractures, falls, cardiovascular or autoimmune diseases, and

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Section: Effects Of Vitamin D On the Cardiac Systemmentioning

confidence: 99%

Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice

Souberbielle¹,

Body

Lappe

et al. 2010

Autoimmunity Reviews

Self Cite

491

375

View full text Add to dashboard Cite

show abstract

“…Il existerait en fait une action biphasique de la vitamine D sur le risque de calcifications vasculaires : augmentation quand la concentration de 25(OH)D est basse mais aussi lorsqu'elle est élevée du fait d'une augmentation du produit phosphocalcique, avec des seuils qui restent à déterminer (Zittermann et al, 2007). Il faut différencier les effets propres de la vitamine D des effets controversés du calcium.…”

Section: Risque Cardiovasculaire De L'intoxication à La Vitamine Dunclassified

Vitamine D et santé cardiovasculaire

Courbebaisse

Cormier

2014

Cahiers de Nutrition et de Diététique

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Résumé -Le déficit en vitamine D touche environ 50 % de la population mondiale. Au-delà de ces effets classiques sur le métabolisme minéral, la vitamine D possède de nombreux effets extra osseux parmi lesquels des effets sur le système cardiovasculaire qui sont essentiellement documentés par des études observationnelles, expérimentales et par de petites études d'intervention s'intéressant la plupart du temps à des paramètres intermédiaires du risque cardiovasculaire. Il est de ce fait temps de conduire de larges études interventionnelles randomisées contre placebo, ciblant les effets de la vitamine D native sur les événements et la mortalité cardiovasculaire. Mots clés : Vitamine D / événements cardiovasculaires / diabèteAbstract -Vitamin D and cardiovascular health. Vitamin D deficiency affects almost 50% of the population worldwide. Besides its classical effects on bone and calcium metabolism, vitamin D displays a wide spectrum of non classical effects. Among these effects, those targeting the cardiovascular system are mostly documented by observational, experimental and small intervention trials that most often evaluated intermediate parameters. The time has now come for large placebo-controlled trials targeting clinical endpoints such as the incidence of major cardiovascular events and mortality.

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“…However, the studies after solid organ transplantation are lacking. Furthermore, higher doses of vitamin D may be associated with increased risk for vascular calcifications [84].…”

Section: Vitamin D and Cardiovascular Risk After Ktxmentioning

confidence: 99%

Vitamin D and Renal Disease

Filipov¹,

Zlatkov²,

Dimitrov³

2017

A Critical Evaluation of Vitamin D - Clinical Overview

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The metabolism of vitamin D (VD) is severely impaired in chronic kidney disease (CKD). Uremia is not only associated with the reduction of its active form 1,25-dihydroxyvitamin D but also in the reduction of all VD metabolites. CKD-associated abnormalities in VD are part of the CKD-related mineral-bone disease. However, VD has beneficial effect on the kidneys due to its pleiotropic effects, namely, antiproteinuric effect and reninangiotensin-aldosterone system suppression, thus making the relationship between VD and the kidney even more complicated. The aim of our chapter is to reveal the changes in vitamin D axis in CKD, to outline the possible beneficial effects of vitamin D in renal patients, including end-stage renal patients and kidney transplant recipients, and to address the current opinions concerning treatment with cholecalciferol, calcitriol, and vitamin D analogs.

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Vitamin D and vascular calcification

Abstract: Available data indicate that vitamin D exerts a biphasic 'dose response' curve on vascular calcification with deleterious consequences not only of vitamin D excess but also of vitamin D deficiency.

Cited by 174 publications

References 48 publications

Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice

Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice

Vitamine D et santé cardiovasculaire

Vitamin D and Renal Disease

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