Vitamin D and Tuberculosis

Wilkinson, Robert J.; Lange, Christoph

doi:10.1164/rccm.200902-0186ed

Cited by 14 publications

(2 citation statements)

References 19 publications

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“…The results of our previous study using proteomic analysis of patients with diphenyl-methane diisocyanate occupational asthma (MDI-OA) showed upregulation of vitamin D-binding protein (VDBP) expression (Hur et al, 2008a). There has been much interest in the role of the vitamin D axis in lung disease such as asthma, chronic obstructive pulmonary disease and tuberculosis (Devereux et al, 2009; Janssens et al, 2009; Wilkinson and Lange, 2009; Chishimba et al, 2010), which includes vitamin D and VDBP. Various cytokines, cellular elements, oxidative stress and protease/antiprotease levels affect lung fibroproliferation, remodeling and function, which may be influenced by vitamin D level (Gilbert et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Role of vitamin D-binding protein in isocyanate-induced occupational asthma

et al. 2012

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The development of a serological marker for early diagnosis of isocyanate-induced occupational asthma (isocyanate-OA) may improve clinical outcome. Our previous proteomic study found that expression of vitamin D-binding protein (VDBP) was upregulated in the patients with isocyanate-OA. In the present study, we evaluated the clinical relevance of VDBP as a serological marker in screening for isocyanate-OA among exposed workers and its role in the pathogenesis of isocyanate-OA. Three study groups including 61 patients with isocyanate-OA (group I), 180 asymptomatic exposed controls (AECs, group II), 58 unexposed healthy controls (NCs, group III) were enrolled in this study. The baseline serum VDBP level was significantly higher in group I compared with groups II and III. The sensitivity and specificity for predicting the phenotype of isocyanate-OA with VDBP were 69% and 81%, respectively. The group I subjects with high VDBP (≥ 311 µg/ml) had significantly lower PC20 methacholine levels than did subjects with low VDBP. The in vitro studies showed that TDI suppressed the uptake of VDBP into RLE-6TN cells, which was mediated by the downregulation of megalin, an endocytic receptor of the 25-hydroxycholecalciferol-VDBP complex. Furthermore, toluene diisocyanate (TDI) increased VEGF production and secretion from this epithelial cells by suppression of 1,25-dihydroxycholecalciferol [1,25(OH)2D3] production. The findings of this study suggest that the serum VDBP level may be used as a serological marker for the detection of isocyanate-OA among workers exposed to isocyanate. The TDI-induced VEGF production/secretion was reversed by 1,25(OH)2D3 treatment, which may provide a potential therapeutic strategy for patients with isocyanate-OA.

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Section: Introductionmentioning

confidence: 99%

Role of vitamin D-binding protein in isocyanate-induced occupational asthma

et al. 2012

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“…In recent years, several lines of evidence suggest a link between vitamin D and TB [4-7]. The active form of vitamin D (1,25(OH)2D3) has been shown to inhibit growth of Mycobacterium tuberculosis ( M. tuberculosis ) through stimulating cell-mediated immunity and activating monocytes [6].…”

Section: Introductionmentioning

confidence: 99%

Association between vitamin D insufficiency and tuberculosis in a vietnamese population

Ho‐Pham

Nguyen

et al. 2010

BMC Infect Dis

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BackgroundRecent in vitro evidence suggests a link between vitamin D status and the risk of tuberculosis (TB). This study sought to examine the association between vitamin D status, parathyroid hormone (PTH) and the risk of TB in a Vietnamese population.MethodsThe study was designed as a matched case-control study, which involved 166 TB patients (113 men and 53 women), who were age-and-sex matched with 219 controls (113 men and 106 women). The average age of men and women was 49 and 50, respectively. TB was diagnosed by the presence of acid-fast bacilli on smears from sputum, and the isolation of M. tuberculosis. All patients were hospitalized for treatment in a TB specialist hospital. Controls were randomly drawn from the general community within the Ho Chi Minh, Vietnam. 25-hydroxyvitamin D [25(OH)D] and PTH was measured prior to treatment by an electrochemiluminescence immunoassay (ECLIA) on a Roche Elecsys. A serum level of 25(OH)D below 30 ng/mL was deemed to be vitamin D insufficient.ResultsThe prevalence of vitamin D insufficiency was 35.4% in men with TB and 19.5% in controls (P = 0.01). In women, there were no significant differences in serum 25(OH)D and serum PTH levels between TB patients and controls. The prevalence of vitamin D insufficiency in women with TB (45.3%) was not significantly different from those without TB (47.6%; P = 0.91). However, in both genders, serum calcium levels in TB patients were significantly lower than in non-TB individuals. Smoking (odds ratio [OR] 1.25; 95% confidence interval [CI] 1.10 - 14.7), reduced 25(OH)D (OR per standard deviation [SD]: 1.14; 95% CI 1.07 - 10.7) and increased PTH (OR per SD 1.13; 95% CI 1.05 - 10.4) were independently associated with increased risk of TB in men.ConclusionThese results suggest that vitamin D insufficiency was a risk factor for tuberculosis in men, but not in women. However, it remains to be established whether the association is a causal relationship.

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