Vitamin D and Trabecular Bone Score in a Group of Young Lebanese Adults

Alwan, Abir; Rassy, Nathalie Al; Berro, Abdel-Jalil; Rizkallah, Maroun; Matta, Joseph; Frenn, Fabienne; Bachour, Falah; Sebaaly, Amer; Maalouf, Ghassan; Hage, Rawad El

doi:10.1016/j.jocd.2018.02.002

Cited by 15 publications

(8 citation statements)

References 37 publications

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“…Participants with history of vitamin D supplementation surprisingly had lower TBS compared to those who did not receive vitamin D in our study, which was seemingly contradicting preceding studies which showed that vitamin D deficiency was associated with lower TBS [ 35 36 ]. Participants with history of vitamin D supplementation in our study might indeed, had lower serum 25-hydroxyvitamin D level to begin with, and therefore, had vitamin D prescribed.…”

Section: Discussioncontrasting

confidence: 99%

Trabecular Bone Score as a Risk Factor of Major Osteoporotic Fracture in Postmenopausal Women: The First Study in Thailand

Therdyothin

Amphansap

2022

J Menopausal Med

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Objectives To compare the trabecular bone score (TBS) between Thai postmenopausal women with and without major osteoporotic fracture, and to determine whether TBS is associated with fracture risk. Methods All postmenopausal women sent for dual-energy X-ray absorptiometry (DXA) at the Police General Hospital were retrospectively recruited. The hospital’s online database and radiographs were reviewed to collect information on underlying disease, medication, previous fractures, bone mineral density, and trabecular bone score. Patients with anti-osteoporotic medication use, skeletal malignancy, fracture from high-energy trauma, and uninterpretable DXA images were excluded. Results A total of 407 Thai postmenopausal women were enrolled. They were divided into 292 women without fractures and 115 women with major osteoporotic fractures. The fracture group was older (73.36 ± 9.95 vs. 66.00 ± 8.58, P < 0.001) and had lower serum 25-hydroxyvitamin D levels (23.28 ± 9.09 vs. 26.44 ± 9.20, P = 0.023). The mean TBS was lower in the fracture group, compared to the non-fracture group (1.244 ± 0.101 vs. 1.272 ± 0.099, P = 0.011). The subgroup analysis resulted in noticeably lower TBS in spine fracture, but not other fracture sites. The odds ratio of fracture was 1.355 ( P = 0.013) for a decrease in one standard deviation of TBS. Conclusions TBS was significantly lower in postmenopausal women having fractures with an odd ratio of 1.355 ( P = 0.013) per SD decrease in TBS. Categorizing by fracture sites, TBS was only found to be noticeably lower in the lumbar spine despite similar lumbar spine bone mineral density.

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Section: Discussioncontrasting

confidence: 99%

Trabecular Bone Score as a Risk Factor of Major Osteoporotic Fracture in Postmenopausal Women: The First Study in Thailand

Therdyothin

Amphansap

2022

J Menopausal Med

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“…Moreover, the TBS was significantly higher in the vitamin D sufficient group as compared to the group with vitamin D deficiency. [ 28 ] In the present study, the lower vitamin D may have partially contributed to the lower TBS in cases as compared to controls. However, the contribution of hitherto unknown factors pertaining to the disease contributing to lower TBS needs to be further elucidated.…”

Section: Discussionmentioning

confidence: 57%

Do Bone Mineral Density, Trabecular Bone Score, and Hip Structural Analysis Differ in Indian Men with Parkinson’s Disease? A Case-Control Pilot Study from a Tertiary Center in Southern India

Sooragonda

Sridharan

Benjamin

et al. 2023

Annals of Indian Academy of Neurology

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Objective: Parkinson’s disease (PD) is a neurodegenerative condition that is characterized by bradykinesia, rigidity, and gait instability. Inherent to this condition is an increased predisposition to falls and fractures. Bone health in Parkinson’s disease in India has not been studied thus far. This study aimed to assess the bone mineral density (BMD), trabecular bone score (TBS), and hip structural analysis (HSA) in Indian men with PD and compare them with matched controls. Methodology: A case-control study done at a tertiary care center from southern India. Bone biochemistry, BMD, TBS, and HSA were assessed. Results: Among 40 cases and 40 age, gender, and body mass index (BMI)-matched controls, there was no significant difference in BMD between both groups. The mean (SD) TBS at the lumbar spine [1.349 (0.090)] was significantly (P = 0.019) lower in men with PD as compared to matched controls [1.401 (0.089)]. Among the parameters of HSA, the buckling ratios were significantly higher at the femoral neck [11.8 (2.2) vs 9.4 (2.2); P = 0.001] and inter-trochanteric region [9.4 (2.1) vs 7.8 (1.4); P = 0.002] among cases as compared to matched controls. Vitamin D deficiency was significantly higher in this cohort of patients as was bone turnover marker indicating bone loss and a high bone turnover state. Conclusion: A comprehensive bone health assessment comprising BMD, TBS, and HSA may be required to capture all aspects of bone strength in Indian men with PD as BMD assessment as a stand-alone tool may not suffice to obtain all information pertaining to fracture risk in these individuals.

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“…In both sexes, TBS was significantly higher in 25(OH) D-sufficient participants (≥30 ng/mL). In this study vitamin D positively affects bone health and suggests that maintaining an adequate level of vitamin D may be essential for optimal TBS values [32].…”

Section: Tbs and Secondary Hyperparathyroidismmentioning

confidence: 66%

TBS (Trabecular Bone Score) Used for Evaluation of Patients with Primary and Secondary Hyperparathyroidism

Santos¹,

Orozco²

2023

Parathyroid Glands - New Aspects

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The increase in parathyroid hormone (PTH) is related to a worse quality of bone mass. Bone densitometry, as an areal bone measurement, is not always able to assess bone microarchitecture. TBS (trabecular bone score) is a software that evaluates bone microarchitecture from the image of the lumbar spine obtained by bone densitometry. The articles have shown an excellent correlation of TBS with the risk of fragility fracture, especially in the individual who has primary hyperparathyroidism. We suggest that TBS may be an excellent method for assessing bone fragility in patients with hyperparathyroidism, especially if TBS is associated with bone densitometry.

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Vitamin D and Trabecular Bone Score in a Group of Young Lebanese Adults

Cited by 15 publications

References 37 publications

Trabecular Bone Score as a Risk Factor of Major Osteoporotic Fracture in Postmenopausal Women: The First Study in Thailand

Trabecular Bone Score as a Risk Factor of Major Osteoporotic Fracture in Postmenopausal Women: The First Study in Thailand

Do Bone Mineral Density, Trabecular Bone Score, and Hip Structural Analysis Differ in Indian Men with Parkinson’s Disease? A Case-Control Pilot Study from a Tertiary Center in Southern India

TBS (Trabecular Bone Score) Used for Evaluation of Patients with Primary and Secondary Hyperparathyroidism

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