Vitamin D and the skin: Focus on a complex relationship: A review

Mostafa, Wedad Z.; Hegazy, Rehab A.

doi:10.1016/j.jare.2014.01.011

Cited by 188 publications

(230 citation statements)

References 141 publications

(171 reference statements)

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“…A UVB exposure for 15-20 minutes capable of inducing light pink color of the minimal erythema is able to produce up to 250 lg vitamin D which is then released into circulation (~0.1 lM) [31]. Following an incubation of 21 days, the extent of glycation was determined using modified Nitro Blue tetrazolium method.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D prevents glycation of proteins: an in vitro study

2016

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Human serum albumin (HSA) is an important protein involved in the transport of hormones, fatty acids, drugs, and other macromolecules. Under hyperglycemic conditions, this molecule undergoes irreversible modification that affects its structure and function. In this study, we explored the effect of two forms of vitamin D, a nutraceutical, on glycation modification in HSA. The protein was incubated with a physiologically high concentration of glucose in the presence of vitamin D metabolites. After 21 days, samples were tested for secondary structural changes, side chain modification, and the presence of advanced glycation end products. Vitamin D metabolites could reduce glycation modification, albeit only to a small extent. Interaction studies reveal that Vitamin D interaction with HSA can prevent protein glycation.Keywords: calcitriol; glycation; protein Type 2 Diabetes is a global health issue growing at an unprecedented rate. The disease accounts for 90% of diabetes cases worldwide and is characterized by defects in glucose metabolism [1]. Persistently high blood glucose concentration encountered in diabetes often initiates Maillard reaction which causes nonenzymatic glycation of proteins and yields a plethora of reactive compounds called advanced glycation end products (AGEs) [2].Modification of protein structure and function by AGEs is consistent with the progression of diabetic complications and correlates positively with the severity of conditions like retinopathy, neuropathy, and nephropathy [3]. Once initiated, AGEs formation continues throughout the lifespan of proteins, and cannot be reversed by normalizing hyperglycemia [2,4].Human serum albumin (HSA) frequently undergoes Maillard reaction to from covalently cross-linked composites [3]. In normal adults, 6-10% of lysine chains are modified by nonenzymatic glycation, however, this number increases by 2-3 folds in individuals suffering from diabetes [5]. This may interfere with HSA function [5]. Since HSA is involved in the transportation of several moieties: nutrients, steroids, and a wide variety of drugs this can have detrimental physiological effects [6].Research suggests that vitamin D is involved in controlling AGE-associated damage in both diabetes and heart disorders [7]. Vitamin D is a fat-soluble micronutrient which is produced in the body by UV irradiation of a precursor steroid stored in the skin. The functionally active form of vitamin D, calcitriol, has a wide array of health implications [8]. Multiple studies have demonstrated its ability in limiting oxidative damage and regulating the status of a potent cellular antioxidant-reduced glutathione (GSH) [7]. Vitamin D deficiency is thought to be a risk factor for the development of diabetes; Low vitamin D status is associated with increased insulin resistance, glycated hemoglobin (HbA1c), and AGE formation [9][10][11]. Previous reports have correlated low circulating concentrations of vitamin D with increased risk of diabetic macrovascular and microvascular complications: mainly nephropathy a...

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Section: Discussionmentioning

confidence: 99%

Vitamin D prevents glycation of proteins: an in vitro study

2016

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“…Its incrimination in skin diseases has been under the spot light in the recent years. Concerning its relation with AD, animal studies, case reports, and randomized clinical trials have suggested the role of calcidiol, through various mechanisms including immunomodulation [4]. Furthermore, an inverse relationship between the severity of AD and calcidiol levels has been previously suggested, and studies have shown that, in individuals with AD who are deficient in calcidiol, repletion of calcidiol results in improvement and decreased severity of the disease [5][6][7]; a notion that has been denied by others [8,9].…”

Section: Introductionmentioning

confidence: 99%

Estimation of Calcidiol Level in Serum of Atopic Dermatitis Patients before and after NB-UVB Phototherapy in Comparison to Oral Vitamin D Therapy

Youssef¹,

Dorgham²,

Hegazy³

et al. 2017

J Clin Exp Dermatol Res

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“…Vitamin D and/or its receptor regulate numerous functions of the skin. These include inhibition of proliferation and stimulation of cell differentiation (3) . According to Bikle (4) , vitamin D regulates formation of the permeability barrier, promotion of innate immunity, and promotion of the hair follicle cycle.…”

Section: Introductionmentioning

confidence: 99%

“…A Vitamina D e/ou o seu receptor regulam numerosas funções da pele. Estas incluem a inibição da proliferação e estimulação da diferenciação celular (3) . De acordo com Bikle (4) , a Vitamina D regula a formação da barreira de permeabilidade, a promoção da imunidade inata e a promoção do ciclo do folículo capilar.…”

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Immediate and long term effects of a cosmetic formulation with Cichorium intybus root extract

Paseto¹,

Wagemaker²,

Campos³

2017

BBR

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220 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c a Immediate and long term effects of a cosmetic formulation with Cichorium intybus root extract AbstractDry skin is characterized as a rough and scaling skin surface. It usually has lower water content than normal skin. Vitamin D helps to regulate cellular proliferation and differentiation andcan help to protect skin from environmental factors. However, the stability vitamin D in cosmetic formulations is low. Thus, the aim of this study was to evaluate the sensory properties and protective effects on skin hydration of a cosmetic formulation containing Cichorium intybus root extract, previously shown to be "vitamin D like" (VD). A formulation containing VD or not (vehicle) was applied on the arm, forearm and face of fifteen subjects. Measurements of stratum corneum water content, Transepidermal Water Loss (TEWL) and skin microrelief parameters were performed using biophysical and skin image techniques before (baseline), after 2 hours, and after 45 and 90 days of daily application of the formulations. Only the formulation with VD was effective in maintaining skin barrier function and skin hydration under low humidity conditions. Cichorium intybus root extract is shown to be an effective "vitamin D like" active ingredient to use in cosmetic formulations to avoid skin dryness. In addition, the extract maintained the sensory properties of the studied cosmetic formulation.Keywords: Cichorium intybus root extract, "Vitamin D-like", cosmetics, biophysical techniques, skin dryness, sensory properties ResumoA pele seca é caracterizada como uma superfície áspera, com menor teor de água do que a pele normal. A Vitamina D ajuda a regular a proliferação e diferenciação celular e pode ajudar a proteger a pele contra fatores ambientais. No entanto, a Vitamina D é instável em formulações cosméticas. Assim, o objetivo deste estudo foi avaliar o sensorial e os efeitos protetores na hidratação da pele de uma formulação cosmética contendo extracto de raiz Cichorium intybus -"Vitamina D like" (VD). A formulação, adicionada ou não (veículo) de VD, foi aplicada no braço, antebraço e na face de quinze participantes. Antes (basal) e após 2 horas, 45 e 90 dias de aplicação diária das formulações foram realizadas medidas do conteúdo aquoso do estrato córneo, perda de água transepidémica e parâmetros do microrrelevo da pele por técnicas biofísicas e análise de imagem. Apenas a formulação com VD foi efetiva na manutenção da função barreira e hidratação da pele em condições de baixa umidade. Assim, oextracto de raíz de Cichorium intybus é um ingrediente ativo eficaz para aplicação em cosméticos para evitar o ressecamento da pele. Além disso, a "Vitamina D like" melhorou o sensorial da formulação cosmética estudada.Palavras chave: extracto de raiz de Cichorium intybus, "Vitamina D-like", cosméticos, técnicas de biofísica, pele seca, propriedades sensoriais.

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Vitamin D and the skin: Focus on a complex relationship: A review

Abstract: Graphical abstract

Cited by 188 publications

References 141 publications

Vitamin D prevents glycation of proteins: an in vitro study

Vitamin D prevents glycation of proteins: an in vitro study

Estimation of Calcidiol Level in Serum of Atopic Dermatitis Patients before and after NB-UVB Phototherapy in Comparison to Oral Vitamin D Therapy

Immediate and long term effects of a cosmetic formulation with Cichorium intybus root extract

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