Vitamin D and the central nervous system

Wrzosek, Małgorzata; Łukaszkiewicz, Jacek; Wrzosek, Michał; Jakubczyk, Andrzej; Matsumoto, Halina; Piątkiewicz, Paweł; Radziwoń-Zaleska, Maria; Wojnar, Marcin; Nowicka, Grażyna

doi:10.1016/s1734-1140(13)71003-x

Cited by 162 publications

(129 citation statements)

References 66 publications

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“…VD used in the present study as two daily therapeutic doses; low (1000 IU) in group IIa and high (4000 IU) in group IIIa according to [32] who stated that six studies preferred daily oral supplementation strategies by using dosages between 1000 and 4000 IU and this agreed with [33,34] who stated that the supplementation was within the range of 1000-4000 IU/ day of VD often nowadays considered as the daily physiological requirement. Glendenning et al, and Holick et al, used VD in a daily dose 1000 IU in their studies while [37] and [38] used VD in a daily dose 4000 IU.…”

Section: Discussionsupporting

confidence: 71%

Does vitamin D have protective effect on human nasal polyposis: histological and immunohistochemical study

Faruk¹,

Yousef²,

Mohamed³

2014

J Histol Histopathol

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Background: Nasal polyps (NPs) are benign pedicled mucosal protrusions into the nasal cavity of multifactorial origin. Vitamin D has been demonstrated as having potential immunomodulatory activity and act as an antiproliferative agents. Aim of the work: To determine the possible antiproliferative effect and immunomodulatory activity of VD on human nasal polyposis. Material and methods: Based on thirty patients and divided equally into 3 groups. Group Ι (healthy subjects). Group ΙΙ were received low daily oral dose of VD(1000 IU) for 4 weeks. Group ΙΙΙ were received high daily oral dose of VD(4000 IU) for 4 weeks.Each group ΙΙ and ΙΙΙ divided into 2 subgroups; group b: patients with NP before taking VD and group a: patients with NP after taking. Nasal biopsies were obtained of all groups for histological examination and immunohistochemical detection of Toll-like receptors 9 expression. Results: patients of nasal polyps before VD taking (groups IIb and IIIb) presented with symptoms of Visual Analogue Scale, VAS score (facial pain, headache, nasal blockage, nasal discharge, post-nasal drip and olfactory disturbance) and endoscopic appearance of Lund and Mackey score (polypi, edema and discharge), damage of respiratory epithelium, extensive accumulation of collagen fibers in lamina propria and highly expressed TLR-9. The high dose VD group (IIIa) showed near normal respiratory epithelium, significant decrease (P<0.05) in all symptoms of VAS score, endoscopic appearance of Lund and Mackey score. The mean area % of submucosal accumulation of collagen fibers and TLR-9 expression were also significant decreased but decrease was insignificant (P<0.05) in the low dose VD group (IIa). Conclusion: VD participate significantly in protection against human nasal polyposis when used by high therapeutic dose, by reducing the size of nasal polyps, relieving the symptoms and signs of nasal polyposis.

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Section: Discussionsupporting

confidence: 71%

Does vitamin D have protective effect on human nasal polyposis: histological and immunohistochemical study

Faruk¹,

Yousef²,

Mohamed³

2014

J Histol Histopathol

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“…29,30 It is noteworthy that vitamin D receptors are present throughout the brain, including the primary motor cortex. 31,32 They have been identified in both neuronal and glial cells within the cortex, in deep grey matter, in the cerebellum, in brainstem nuclei and in the spinal cord and the ventricular system. Furthermore, the enzyme 1,α-hydroxylase, the activator of vitamin D precursors, is also present in the brain.…”

Section: Effects Of Vitamin D On the Nervous Systemmentioning

confidence: 99%

Muscular effects of vitamin D in young athletes and non-athletes and in the elderly

Koundourakis¹,

Avgoustinaki²,

Malliaraki³

et al. 2017

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“…The nuclear VDR heterodimerizes with retinoid X receptor and in concert with several coactivators regulates the transcription of a wide variety of genes in different tissues [171,172]. In CNS development, vitamin D helps in neuronal differentiation and axonal growth, and in the adult brain it regulates the synthesis of neurotrophic factors and neurotransmitters and also exhibits neuroprotective and antioxidative functions [173,174,175].…”

Section: Vitamin Dmentioning

confidence: 99%

Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and Treatment

Chakrabarti¹,

Khemka²,

Banerjee³

et al. 2015

Aging and disease

111

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Alzheimer's disease (AD), the major cause of dementia among the elderly world-wide, manifests in familial and sporadic forms, and the latter variety accounts for the majority of the patients affected by this disease. The etiopathogenesis of sporadic AD is complex and uncertain. The autopsy studies of AD brain have provided limited understanding of the antemortem pathogenesis of the disease. Experimental AD research with transgenic animal or various cell based models has so far failed to explain the complex and varied spectrum of AD dementia. The review, therefore, emphasizes the importance of AD related risk factors, especially those with metabolic implications, identified from various epidemiological studies, in providing clues to the pathogenesis of this complex disorder. Several metabolic risk factors of AD like hypercholesterolemia, hyperhomocysteinemia and type 2 diabetes have been studied extensively both in epidemiology and experimental research, while much less is known about the role of adipokines, proinflammatory cytokines and vitamin D in this context. Moreover, the results from many of these studies have shown a degree of variability which has hindered our understanding of the role of AD related risk factors in the disease progression. The review also encompasses the recent recommendations regarding clinical and neuropathological diagnosis of AD and brings out the inherent uncertainty and ambiguity in this area which may have a distinct impact on the outcome of various population-based studies on AD-related risk factors.

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Vitamin D and the central nervous system

Cited by 162 publications

References 66 publications

Does vitamin D have protective effect on human nasal polyposis: histological and immunohistochemical study

Does vitamin D have protective effect on human nasal polyposis: histological and immunohistochemical study

Muscular effects of vitamin D in young athletes and non-athletes and in the elderly

Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and Treatment

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