Vitamin D and the Cardiovascular System

Riek, Amy E.; Rajagopal, Rithwick; Bernal‐Mizrachi, Carlos

doi:10.1016/b978-0-12-809965-0.00032-x

Cited by 3 publications

(2 citation statements)

References 193 publications

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“…Vitamin D receptors (VDRs) in tissues and cells are involved in the biological function of vitamin D (Valdivielso and Fernandez, 2006; Tirabassi et al , 2018; Riek et al , 2018; Mayne and Burne, 2019; Tangpricha et al , 2019). In addition to VDRs, there is another enzyme with named 1-α hydroxylase, which transforms vitamin D to its active form (1, 25(OH) D) in the brain (Bivona et al , 2019).…”

Section: Dementia Risk Factorsmentioning

confidence: 99%

The comprehensive mechanistic insight into the effects of vitamin D on dementia – a review

Jafarzadeh¹,

Payahoo

Yousefi

et al. 2021

NFS

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Purpose This paper aims to depict the mechanistic role of vitamin D on dementia prevention, relief of the severity and the complication of the disease. All papers indexed in scientific databases, including Scopus, Elsevier, PubMed, Embase and Google Scholar between 2000 and 2021 were extracted and discussed. To present the mechanistic role of vitamin D in declining the severity of dementia, keywords including dementia, vitamin D, oxidative stress, inflammation, amyloid beta-Peptides were used. Design/methodology/approach Dementia is a prevalent cognitive disorder worldwide, especially in elderly people, which is accompanied by serious disabilities. Besides genetic, biological and lifestyle factors are involved in the incidence of dementia. An unhealthy diet along with micronutrient deficiencies are among modifiable factors. Vitamin D is one of the important micronutrients in brain health. Besides the involvement in gene expression, bone mineralization, apoptosis, inflammation, skeletal maturation, neurotropic action and hemostasis of phosphate and calcium, vitamin D also exerts neuroprotective effects via genomic and non-genomic pathways. Findings Vitamin D up-regulates the expression of various genes involved in dementia incidence via various mechanisms. Decreasing oxidative stress and the neuro-inflammatory cytokines levels, regulation of the expression of alternated Proteins including Tau and Amyloid-ß, calcium homeostasis in the central nervous system and also vascular are considered main mechanisms. Originality/value Considering the importance of diet in preventing dementia, adherence to a healthy diet that provides essential nutrients to brain function seems to be urgent. Controlling serum levels of vitamin D periodically and providing vitamin D by related sources or supplements, if there is a deficiency, is recommended. Future studies are needed to clarify other related mechanisms.

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Section: Dementia Risk Factorsmentioning

confidence: 99%

The comprehensive mechanistic insight into the effects of vitamin D on dementia – a review

Jafarzadeh¹,

Payahoo

Yousefi

et al. 2021

NFS

View full text Add to dashboard Cite

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“…Due to its structure, it acts more like a hormone. In fact, its metabolites also have different activities, which can influence other processes such as cellular differentiation and proliferation, immune system regulation, central nervous system function and cardiovascular health [ 2 , 3 ]. For these functions, it seems that vitamin D plays an important role in preventing the development of tumors [ 4 , 5 ], cardiovascular diseases, multiple sclerosis, type 1 diabetes, infectious diseases and other conditions [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Vitamin D in Prophylaxis and Treatment in Tuberculosis Patients

Papagni

Pellegrino

Gennaro

et al. 2022

IJMS

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Vitamin D plays a crucial role in many infectious diseases, such as tuberculosis (TB), that remains one of the world’s top infectious killers with 1.5 million deaths from TB in 2021. Vitamin D suppresses the replication of Mycobacterium tuberculosis in vitro and showed a promising role in TB management as a result of its connection with oxidative balance. Our review encourages the possible in vivo benefit of a joint administration with other vitamins, such as vitamin A, which share a known antimycobacterial action with vitamin D. However, considering the low incidence of side effects even at high dosages and its low cost, it would be advisable to assess vitamin D level both in patients with active TB and high-risk groups and administer it, at least to reach sufficiency levels.

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