Vitamin D and testosterone co-ordinately modulate intracellular zinc levels and energy metabolism in prostate cancer cells

Zhang, Polly; Schatz, Adam; Adeyemi, B. A.; Kozminski, David J.; Welsh, JoEllen; Tenniswood, Martin; Wang, Wei-Lin Winnie

doi:10.1016/j.jsbmb.2019.01.006

Cited by 12 publications

(8 citation statements)

References 67 publications

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“…These results are in agreement with a study which shows that 1,25(OH) 2 D, either alone or in combination with testosterone, increased neutral lipid accumulation in C4-2B prostate cancer cells, although 1,25(OH) 2 D treatment alone was insufficient to mediate this effect in PC346C or LNCaP cells (P. Zhang et al, 2019). Increased lipid accumulation induced by 1,25(OH) 2 D may be driven by an increase in peroxisome-proliferator activated receptor alpha (PPARα) (Esquenet et al, 1997;Wang & Tenniswood, 2014;Wang et al, 2013;P. Zhang et al, 2019), a key activator of lipid synthesis (Knight et al, 2005).…”

Section: Vitamin D Regulation Of Lipid Metabolismsupporting

confidence: 92%

“…For example, 1,25(OH) 2 D and its analogue 1‐hydroxyvitamin D 5 increased lipid accumulation in several human breast cancer cell lines (Lazzaro et al, 2000; Mehta et al, 2000; Punj et al, 2004). These results are in agreement with a study which shows that 1,25(OH) 2 D, either alone or in combination with testosterone, increased neutral lipid accumulation in C4‐2B prostate cancer cells, although 1,25(OH) 2 D treatment alone was insufficient to mediate this effect in PC346C or LNCaP cells (P. Zhang et al, 2019). Increased lipid accumulation induced by 1,25(OH) 2 D may be driven by an increase in peroxisome‐proliferator activated receptor alpha (PPARα) (Esquenet et al, 1997; Wang & Tenniswood, 2014; Wang et al, 2013; P. Zhang et al, 2019), a key activator of lipid synthesis (Knight et al, 2005).…”

Section: Vitamin D Regulation Of Lipid Metabolismsupporting

confidence: 92%

“…First, additional research is required to determine the differential mechanisms driving either increased or decreased lipid accumulation in 1,25(OH) 2 D‐treated cells. Further, current evidence from models of breast, colon and prostate cancer suggest that cancer stage, molecular subtype and tumour microenvironment may all contribute to the net effect of 1,25(OH) 2 D on lipid accumulation (Zhang et al, 2019). Finally, although several preclinical models indicate that vitamin D metabolites and analogues alter lipid metabolism, additional research is needed to causally link changes in lipid metabolism with cancer‐related outcomes, such as migration and metastasis.…”

Section: Vitamin D Regulation Of Lipid Metabolismmentioning

confidence: 99%

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Vitamin D regulation of energy metabolism in cancer

Sheeley

Andolino

Kiesel

et al. 2021

British J Pharmacology

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Vitamin D exerts anti‐cancer effects in recent clinical trials and preclinical models. The actions of vitamin D are primarily mediated through its hormonal form, 1,25‐dihydroxyvitamin D (1,25(OH)2D). Previous literature describing in vitro studies has predominantly focused on the anti‐tumourigenic effects of the hormone, such as proliferation and apoptosis. However, recent evidence has identified 1,25(OH)2D as a regulator of energy metabolism in cancer cells, where requirements for specific energy sources at different stages of progression are dramatically altered. The literature suggests that 1,25(OH)2D regulates energy metabolism, including glucose, glutamine and lipid metabolism during cancer progression, as well as oxidative stress protection, as it is closely associated with energy metabolism. Mechanisms involved in energy metabolism regulation are an emerging area in which vitamin D may inhibit multiple stages of cancer progression. LINKED ARTICLES This article is part of a themed issue on New avenues in cancer prevention and treatment (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.12/issuetoc

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Section: Vitamin D Regulation Of Lipid Metabolismsupporting

confidence: 92%

Section: Vitamin D Regulation Of Lipid Metabolismsupporting

confidence: 92%

Section: Vitamin D Regulation Of Lipid Metabolismmentioning

confidence: 99%

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Vitamin D regulation of energy metabolism in cancer

Sheeley

Andolino

Kiesel

et al. 2021

British J Pharmacology

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“…2). In support of this hypothesis there are reports showing the presence of the VDR in mitochondria 73 as well as on the inhibitory effect of 1,25(OH) 2 D3 on energy yielding metabolism and electron transport [74][75][76][77] and the role of the VDR in this process 78 . We have data to support these findings, identifying co-localization of the VDR, StAR and CYP11A1 within mitochondria of keratinocytes (Fig.…”

Section: Mitochondria As a Switchboard For Vitamin D And Lumisterol Actionsmentioning

confidence: 71%

Photoprotective Properties of Vitamin D and Lumisterol Hydroxyderivatives

Słomiński

Chaiprasongsuk

Janjetovic

et al. 2020

Cell Biochem Biophys

132

142

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We have previously described new pathways of vitamin D3 activation by CYP11A1 to produce a variety of metabolites including 20(OH)D3 and 20,23(OH) 2 D3. These can be further hydroxylated by CYP27B1 to produce their C1α-hydroxyderivatives. CYP11A1 similarly initiates the metabolism of lumisterol (L3) through sequential hydroxylation of the side chain to produce 20(OH)L3, 22(OH)L3, 20,22(OH) 2 L3 and 24(OH)L3. CYP11A1 also acts on 7dehydrocholesterol (7DHC) producing 22(OH)7DHC, 20,22(OH) 2 7DHC and 7dehydropregnenolone (7DHP) which can be converted to the D3 and L3 configurations following exposure to UVB. These CYP11A1-derived compounds are produced in vivo and are biologically

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“…Furthermore, evidence suggests that the abnormal expression of SLC transporters may play a vital role in the pathogenesis of human malignancies [ 36 ]. Polly Zhang et al illustrated that downregulating SLC25A19 limits the availability of the co-factor thiamine pyrophosphate (TPP), achieving additional control of prostate cancer metabolism [ 37 ]. ICAM5, a member of the ICAM family of adhesion proteins, strongly stimulates neurite growth [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

UCHL5 Promotes Proliferation and Migration of Bladder Cancer Cells by Activating c-Myc via AKT/mTOR Signaling

Cao

Yan

Bai

et al. 2022

Cancers

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Ubiquitin C-terminal hydrolase L5 (UCHL5) is a deubiquitinating enzyme (DUB) that removes ubiquitin from its substrates. Associations between UCHL5 and cancer have been reported in various tissues, but the effect of UCHL5 on bladder cancer has not been thoroughly investigated. This study investigates the expression and function of UCHL5 in bladder cancer. UCHL5 was shown to be abnormally expressed using IHC of tissue microarray and Western blotting. Several procedures were performed to assess the effect of UCHL5 overexpression or knockdown on bladder cancer, such as cell proliferation, colony formation, wound-healing, and Transwell assays. In addition, RNA-Seq and Western blotting experiments were used to verify the status of downstream signaling pathways. Finally, bladder cancers with knockdown or overexpression of UCHL5 were treated with either SC79 or LY294002 to examine the participation of the AKT/mTOR signaling pathway and the expression of downstream targets c-Myc, SLC25A19, and ICAM5. In contrast to adjacent tissue samples, we discovered that UCHL5 was substantially expressed in bladder cancer samples. We also found that UCHL5 downregulation significantly suppressed both tumor growth in vivo and cell proliferation and migration in vitro. According to RNA-Seq analyses and Western blotting experiments, the expression of c-Myc, SLC25A19, and ICAM5 was modified as a result of UCHL5 activating AKT/mTOR signaling in bladder cancer cells. All things considered, our findings show that increased UCHL5 expression stimulates AKT/mTOR signaling, subsequently triggering the expression of c-Myc, SLC25A19, and ICAM5, which in turn promotes carcinogenesis in bladder cancer. UCHL5 is therefore a potential target for therapy in bladder cancer patients.

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Vitamin D and testosterone co-ordinately modulate intracellular zinc levels and energy metabolism in prostate cancer cells

Cited by 12 publications

References 67 publications

Vitamin D regulation of energy metabolism in cancer

Vitamin D regulation of energy metabolism in cancer

Photoprotective Properties of Vitamin D and Lumisterol Hydroxyderivatives

UCHL5 Promotes Proliferation and Migration of Bladder Cancer Cells by Activating c-Myc via AKT/mTOR Signaling

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