Vitamin D and systemic lupus erythematosus: Causality and association with disease activity and therapeutics

Ho, Ling-Jun; Wu, Chien-Hsiang; Luo, Shue-Fen; Lai, Jenn-Haung

doi:10.1016/j.bcp.2024.116417

Biochemical Pharmacology

2024

DOI: 10.1016/j.bcp.2024.116417

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Vitamin D and systemic lupus erythematosus: Causality and association with disease activity and therapeutics

Ling-Jun Ho,

Chien-Hsiang Wu,

Shue-Fen Luo

et al.

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Lupus Nephritis from Pathogenesis to New Therapies: An Update

Roveta,

Parodi,

Brezzi

et al. 2024

IJMS

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Lupus Nephritis (LN) still represents one of the most severe complications of Systemic Lupus Erythematosus (SLE) and a major risk factor for morbidity and mortality. However, over the last few years, several studies have paved the way for a deeper understanding of its pathogenetic mechanisms and more targeted treatments. This review aims to provide a comprehensive update on progress on several key aspects in this setting: pathogenetic mechanisms of LN, including new insight into the role of autoantibodies, complement, vitamin D deficiency, and interaction between infiltrating immune cells and kidney resident ones; the evolving role of renal biopsy and biomarkers, which may integrate information from renal histology; newly approved drugs such as voclosporin (VOC) and belimumab (BEL), allowing a more articulate strategy for induction therapy, and other promising phase III-immunosuppressive (IS) agents in the pipeline. Several adjunctive treatments aimed at reducing cardiovascular risk and progression of chronic renal damage, such as antiproteinuric agents, represent an important complement to IS therapy. Furthermore, non-pharmacological measures concerning general lifestyle and diet should also be adopted when managing LN. Integrating these therapeutic areas requires an effort towards a holistic and multidisciplinary approach. At the same time, the availability of an increasingly wider armamentarium may translate into improvements in patient’s renal outcomes over the next decades.

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Lupus Nephritis from Pathogenesis to New Therapies: An Update

Roveta,

Parodi,

Brezzi

et al. 2024

IJMS

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Vitamin D and systemic lupus erythematosus: Causality and association with disease activity and therapeutics

Cited by 1 publication

References 146 publications

Lupus Nephritis from Pathogenesis to New Therapies: An Update

Lupus Nephritis from Pathogenesis to New Therapies: An Update

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