Vitamin D and Sarcopenia: Potential of Vitamin D Supplementation in Sarcopenia Prevention and Treatment

Uchitomi, Ran; Oyabu, Mamoru; Kamei, Yasutomi

doi:10.3390/nu12103189

Cited by 99 publications

(72 citation statements)

References 74 publications

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“…Vitamin D is thought to have many important roles within skeletal muscle including maintaining contractile excitability via intracellular calcium, muscle stem cell proliferation and differentiation and the consequential maintenance of muscle function [ 46 ]. Unsurprisingly, a deficiency or even an insufficiency of vitamin D is correlated with the risk of diseases including sarcopenia, cardiovascular disease, obesity and cancer [ 47 ]. According to the UK Scientific Advisory Committee on Nutrition (SACN), vitamin D deficiency is classified as serum levels of 25-hydroxyvitamin D (25-OH-D) below <25 nmol/L.…”

Section: Mechanisms Driving Sarcopenia In Ibdmentioning

confidence: 99%

Sarcopenia in Inflammatory Bowel Disease: A Narrative Overview

et al. 2021

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Malnutrition is a common condition encountered in patients with inflammatory bowel disease (IBD) and is often associated with sarcopenia (the reduction of muscle mass and strength) which is an ever-growing consideration in chronic diseases. Recent data suggest the prevalence of sarcopenia is 52% and 37% in Crohn’s disease and ulcerative colitis, respectively, however it is challenging to fully appreciate the prevalence of sarcopenia in IBD. Sarcopenia is an important consideration in the management of IBD, including the impact on quality of life, prognostication, and treatment such as surgical interventions, biologics and immunomodulators. There is evolving research in many chronic inflammatory states, such as chronic liver disease and rheumatoid arthritis, whereby interventions have begun to be developed to counteract sarcopenia. The purpose of this review is to evaluate the current literature regarding the impact of sarcopenia in the management of IBD, from mechanistic drivers through to assessment and management.

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Section: Mechanisms Driving Sarcopenia In Ibdmentioning

confidence: 99%

Sarcopenia in Inflammatory Bowel Disease: A Narrative Overview

et al. 2021

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“…Sci. 2021, 22, 5341 2 of 20 performance in elder people [5,6]. Notwithstanding some dietary supplements of VD can be effective in reducing its deficiency, further VD topical application could represent a strategy to counteract skin disease and/or improve muscular function, especially in the case of people suffering from VD deficiency associated with nutrition problems, aging, and hepatic or renal disorders.…”

Section: Introductionmentioning

confidence: 99%

Formulative Study and Intracellular Fate Evaluation of Ethosomes and Transethosomes for Vitamin D3 Delivery

Costanzo

Esposito

Sguizzato

et al. 2021

IJMS

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In this pilot study, ethosomes and transethosomes were investigated as potential delivery systems for cholecalciferol (vitamin D3), whose deficiency has been correlated to many disorders such as dermatological diseases, systemic infections, cancer and sarcopenia. A formulative study on the influence of pharmaceutically acceptable ionic and non-ionic surfactants allowed the preparation of different transethosomes. In vitro cytotoxicity was evaluated in different cell types representative of epithelial, connective and muscle tissue. Then, the selected nanocarriers were further investigated at light and transmission electron microscopy to evaluate their uptake and intracellular fate. Both ethosomes and transethosomes proven to have physicochemical properties optimal for transdermal penetration and efficient vitamin D3 loading; moreover, nanocarriers were easily internalized by all cell types, although they followed distinct intracellular fates: ethosomes persisted for long times inside the cytoplasm, without inducing subcellular alteration, while transethosomes underwent rapid degradation giving rise to an intracellular accumulation of lipids. These basic results provide a solid scientific background to in vivo investigations aimed at exploring the efficacy of vitamin D3 transdermal administration in different experimental and pathological conditions.

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“…There are a number of natural compounds that have been demonstrated to have antioxidants activity [ 169 , 170 , 171 , 172 , 173 , 174 , 175 ]. Vitamin D is a fat-soluble vitamin present in many foods, although it is primarily produced in the skin when it has been exposed to ultraviolet (UV) rays [ 176 ]. The reduction of muscle mass associated with advancing aging has been clearly associated with decreased circulating vitamin D levels, leading to frailty in the elderly and frequent falls [ 177 , 178 , 179 , 180 , 181 ].…”

Section: Epigenetic Regulation Of Nmj Dysfunctionmentioning

confidence: 99%

Age-Related Alterations at Neuromuscular Junction: Role of Oxidative Stress and Epigenetic Modifications

Dobrowolny

Barbiera

Sica

et al. 2021

Cells

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With advancing aging, a decline in physical abilities occurs, leading to reduced mobility and loss of independence. Although many factors contribute to the physio-pathological effects of aging, an important event seems to be related to the compromised integrity of the neuromuscular system, which connects the brain and skeletal muscles via motoneurons and the neuromuscular junctions (NMJs). NMJs undergo severe functional, morphological, and molecular alterations during aging and ultimately degenerate. The effect of this decline is an inexorable decrease in skeletal muscle mass and strength, a condition generally known as sarcopenia. Moreover, several studies have highlighted how the age-related alteration of reactive oxygen species (ROS) homeostasis can contribute to changes in the neuromuscular junction morphology and stability, leading to the reduction in fiber number and innervation. Increasing evidence supports the involvement of epigenetic modifications in age-dependent alterations of the NMJ. In particular, DNA methylation, histone modifications, and miRNA-dependent gene expression represent the major epigenetic mechanisms that play a crucial role in NMJ remodeling. It is established that environmental and lifestyle factors, such as physical exercise and nutrition that are susceptible to change during aging, can modulate epigenetic phenomena and attenuate the age-related NMJs changes. This review aims to highlight the recent epigenetic findings related to the NMJ dysregulation during aging and the role of physical activity and nutrition as possible interventions to attenuate or delay the age-related decline in the neuromuscular system.

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Vitamin D and Sarcopenia: Potential of Vitamin D Supplementation in Sarcopenia Prevention and Treatment

Cited by 99 publications

References 74 publications

Sarcopenia in Inflammatory Bowel Disease: A Narrative Overview

Sarcopenia in Inflammatory Bowel Disease: A Narrative Overview

Formulative Study and Intracellular Fate Evaluation of Ethosomes and Transethosomes for Vitamin D3 Delivery

Age-Related Alterations at Neuromuscular Junction: Role of Oxidative Stress and Epigenetic Modifications

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