Vitamin D and rheumatoid arthritis: an ongoing mystery

Bragazzi, Nicola Luigi; Watad, Abdulla; Neumann, Shana G.; Simon, Michael A.; Brown, Stav; Abu‐Much, Arsalan; Harari, Adam; Tiosano, Shmuel; Amital, Howard; Shoenfeld, Yehuda

doi:10.1097/bor.0000000000000397

Cited by 38 publications

(35 citation statements)

References 70 publications

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“…Currently, there are limited studies that can define this association beyond any reasonable doubt. Existing literature suggests that lower vitamin D intake is associated with increased RA risk, while hypovitaminosis D affects disease activity score, bone-mass index, and regulatory Tcell proliferation in treatment-naïve RA patients (10).…”

Section: Ra Is a Systemic Autoimmune Inflammatory Disorder That Disprmentioning

confidence: 99%

“…induced regulatory T-cells and inhibit the production of pro-inflammatory cytokines and chemokines. Additionally, 1,25(OH) 2 D also suppresses the differentiation of human B-cells and stimulates the production of immunomodulatory host-defense proteins such as LL-37 (8,10,12,13) In the current study, we evaluated the circulating levels of 25(OH)D, the active metabolite of vitamin D, in a cohort of first-degree relatives (FDR) of INA RA patients, and attempted to relate these levels to the onset of clinically detectable RA in individuals who ultimately developed disease. Our results suggest that, as with RA patients, ACPA seropositive FDR exhibit low levels of circulating 25(OH)D as a group, compared to ACPA seronegative FDR.…”

Section: Ra Is a Systemic Autoimmune Inflammatory Disorder That Disprmentioning

confidence: 99%

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Circulating Levels of Free 25(OH)D Increase at the Onset of Rheumatoid Arthritis

Anaparti

Meng

Mahadevappa

et al. 2019

Preprint

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Objective: Epidemiological studies suggest vitamin D deficiency as a potential risk factor for rheumatoid arthritis (RA) development, a chronic autoimmune disorder highly prevalent in indigenous North American (INA) population. We therefore profiled the circulating levels of 25-hydroxyvitaminD [25(OH)D], an active metabolite of vitamin D, in a cohort of at-risk first-degree relatives (FDR) of INA RA patients, a subset of whom subsequently developed RA (progressors). Methods: 2007 onward, serum samples from INA RA patients and FDR were collected at the time of a structured baseline visit and stored at -20°C. Anti-citrullinated protein antibodies (ACPA), 25(OH)D, hs-CRP, vitamin-D binding protein (VDBP) levels were determined using ELISA and rheumatoid factor (RF) seropositivity was determined by nephelometry. Results: We demonstrate that 25 (OH) D concentrations were lower in winter than summer (P=0.0538), and that serum 25(OH)D levels were higher in samples collected and stored after 2013 (P<0.0001). Analysis of samples obtained after 2013 demonstrated that 37.6% of study participants were 25(OH)D insufficient (<75nmol/L). Also, seropositive RA patients and FDR had lower 25(OH)D levels compared to ACPA-/FDR (P<0.05, P<0.01 respectively). Linear regression analysis showed 25(OH)D insufficiency was inversely associated with presence of RA autoantibodies. Longitudinal samples from 14 progressors demonstrated a consistent increase in 25(OH)D levels at the time they exhibited clinically detectable joint inflammation, without any significant change in VDBP levels. Conclusion:We demonstrate that 25(OH)D levels in serum increased at RA onset in progressors.The potential role that vitamin D metabolites and their downstream effects play in RA transition requires further investigation.

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Section: Ra Is a Systemic Autoimmune Inflammatory Disorder That Disprmentioning

confidence: 99%

Section: Ra Is a Systemic Autoimmune Inflammatory Disorder That Disprmentioning

confidence: 99%

Circulating Levels of Free 25(OH)D Increase at the Onset of Rheumatoid Arthritis

Anaparti

Meng

Mahadevappa

et al. 2019

Preprint

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“…Besides, an experimental study in 1998 showed that vitamin D receptor agonists reduced disease expression and worsening of arthritis [20]. Thus, various studies to date which had inconsistent results have been conducted to investigate whether there is a connection between the presence of rheumatic diseases and vitamin D level [1,21]. Factors such as age, gender, BMI, smoking status, living environment, season, receiving vitamin D supplementation may affect the results.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D'nin romatoid artrit üzerindeki etkisi: gerçek mi yoksa sadece hasta algısı mı?

Uçkun

Yurdakul

Kılıçarslan

et al. 2018

Archives of Clinical and Experimental Medicine

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In this study, our aims were to identify vitamin D levels in rheumatoid arthritis (RA) individuals as compared to controls and the impact of vitamin D levels on both objective and subjective assessments in RA patients. Methods: The current study was a prospective case-control study conducted on 108 RA patients and 50 agegender matched healthy controls. We first compared the levels of vitamin D among the RA patients and controls. Demographic and clinical data, parameters of disease activity, inflammatory markers, rheumatoid factor and anti-cyclic citrullinated peptide seropositivity and radiological damage scores were recorded in RA patients. These patients were also demanded to complete RA Quality of Life Questionnaire (RAQoL), fatigue severity scale (FSS) and Health Assessment Questionnaire (HAQ). Results: D vitamin levels in RA patients were significantly lower than healthy controls (p=0.001). Vitamin D deficiency was determined in 73% of the RA patients and 52% of the controls. Vitamin D deficiency was not associated with disease activity (p=0.862). There was no significant relationship among vitamin D levels and all subjective and objective assessments (p>0.05 for all). Conclusion: Vitamin D deficiency was common in RA participants than normal population. However, it was not shown that there was a significant relationship between vitamin D levels and objective and subjective assessments of disease, including disease activity, inflammatory markers, rheumatoid factor and anti-cyclic citrullinated peptide seropositivity, radiological damage scores, RAQoL, FSS and HAQ.

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“…For instance, a low vitamin D level has been shown to be related to an increased prevalence of hypertension; cardiovascular disease; respiratory infections; periodontal disease; certain malignancies including breast, colon, and prostate cancers [3,9,10,11]; and autoimmune conditions such as multiple sclerosis (MS), type 1 diabetes mellitus (DM), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) [12,13,14]. Such observations have led to the postulation that vitamin D supplementation may be a favorable strategy to combat certain health issues, apart from those related to the musculoskeletal system and calcium-phosphate homeostasis.…”

Section: Vitamin D Its Nature and Impact On Various Body Systemsmentioning

confidence: 99%

The Impact of Vitamin D on the Immunopathophysiology, Disease Activity, and Extra-Musculoskeletal Manifestations of Systemic Lupus Erythematosus

Mak

2018

IJMS

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Over the past two decades it has been increasingly recognized that vitamin D, aside from its crucial involvement in calcium and phosphate homeostasis and the dynamics of the musculoskeletal system, exerts its influential impact on the immune system. The mechanistic roles that vitamin D plays regarding immune activation for combating infection, as well as pathologically and mediating autoimmune conditions, have been progressively unraveled. In vitro and in vivo models have demonstrated that the action of vitamin D on various immunocytes is not unidirectional. Rather, how vitamin D affects immunocyte functions depends on the context of the immune response, in the way that its suppressive or stimulatory action offers physiologically appropriate and immunologically advantageous outcomes. In this review, the relationship between various aspects of vitamin D, starting from its adequacy in circulation to its immunological functions, as well as its autoimmune conditions, in particular systemic lupus erythematosus (SLE), a prototype autoimmune condition characterized by immune-complex mediated inflammation, will be discussed. Concurring with other groups of investigators, our group found that vitamin D deficiency is highly prevalent in patients with SLE. Furthermore, the circulating vitamin D levels appear to be correlated with a higher disease activity of SLE as well as extra-musculoskeletal complications of SLE such as fatigue, cardiovascular risk, and cognitive impairment.

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Vitamin D and rheumatoid arthritis: an ongoing mystery

Cited by 38 publications

References 70 publications

Circulating Levels of Free 25(OH)D Increase at the Onset of Rheumatoid Arthritis

Circulating Levels of Free 25(OH)D Increase at the Onset of Rheumatoid Arthritis

Vitamin D'nin romatoid artrit üzerindeki etkisi: gerçek mi yoksa sadece hasta algısı mı?

The Impact of Vitamin D on the Immunopathophysiology, Disease Activity, and Extra-Musculoskeletal Manifestations of Systemic Lupus Erythematosus

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