Vitamin D and respiratory health

Hughes, David A.; Norton, Rosemary

doi:10.1111/j.1365-2249.2009.04001.x

Cited by 218 publications

(194 citation statements)

References 49 publications

(75 reference statements)

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“…One explanation for the respiratory health benefits of vitamin D is found in its anti-inflammatory properties. 2,[12][13][14][15][16] Vitamin D is thought to regulate many cellular processes including immunomodulating the activity of monocytes, macrophages, lymphocytes, and epithelial cells. 10 Both acute and chronic forms of respiratory disease occur in conjunction with inflammation.…”

Section: Introductionmentioning

confidence: 99%

A test of vitamin D benefits on respiratory health mediated through inflammatory markers

Hendryx

Luo

2014

Chron Respir Dis

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Previous studies have shown that vitamin D has beneficial effects on respiratory health. The role of inflammation as a possible mediator between vitamin D and respiratory health is not well understood. We used National Health and Nutrition Examination Survey 2001Survey -2006 to examine the mediating effects of biomarkers of inflammation on associations between vitamin D and respiratory health. Vitamin D was measured by serum 25 hydroxy vitamin D test. Respiratory health was measured by self-reported respiratory symptoms and chronic obstructive pulmonary disease (COPD). Biomarkers included C-reactive protein (CRP), alkaline phosphatase (AP), and five leukocyte measures. Models controlled for season, age, sex, race/ethnicity, body mass index, and current and former smoking. Lower levels of vitamin D were significantly associated with respiratory symptoms (linear trend p < 0.01) and with COPD (linear trend p < 0.0002) after adjusting for covariates. Adding biomarkers to the models to test for mediation, the vitamin D effect on respiratory health was not a consequence of any single marker but was partially attenuated as a combined result of leukocytes, AP, and CRP. Vitamin D is beneficial to improve respiratory health. Its benefits do not appear to be mediated by any single biomarker examined in this study; rather, benefits of vitamin D may act broadly through multiple mediating mechanisms.

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Section: Introductionmentioning

confidence: 99%

A test of vitamin D benefits on respiratory health mediated through inflammatory markers

Hendryx

Luo

2014

Chron Respir Dis

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“…The Upper respiratory tract infection (URTI) results in acute neutrophilic infiltration in respiratory epithelium and production of mucous. With increased amount of mucous, patient is more prone to infections and decrease in pancreatic secretion, which may result in mal-absorption of fat, consequently decreased absorption of vitamin D [5].…”

Section: Introductionmentioning

confidence: 99%

“…Vitamin D regulates more than 200 genes including genes for cellular proliferation and apoptosis [5]. Vitamin D regulated gene expression through binding with Vitamin D Receptor (VDR), which modulates the expression of genes.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency in E.N.T. Patients

Taneja¹,

Taneja

2012

Indian J Otolaryngol Head Neck Surg

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A prospective study to observe the prevalence of deficiency of vitamin D in out patients of otolaryngology clinic at Indian Institute of ear diseases, Muzaffarnagar. The patients attending outpatient of otolaryngology clinic with various complaints and not responding to conventional treatment were advised for assessment of vitamin D [25 (OH)D] level in blood. The age, sex, occupation, colour of skin, chief complaints, obesity, provisional diagnosis, and incidence of sun exposure was noted in all cases. A total of 86 patients were examined, maximum patients were in the age group of 7-15 years. The chief complaints in majority of the patients were sore throat with recurrent upper respiratory tract infection. Only in three patient's vitamin D level was found to be with in normal limits. In rest 83 (96.51 %) it was either deficient 57 (66.28 %) or insufficient 21 (24.42 %). The incidence of vitamin D deficiency is extremely common in Ear Nose Throat disease (E.N.T.) patients. The results of vitamin supplementation were promising in cases of benign paroxysmal positional vertigo with cervical spondylosis and URTI with asthma, empirical supplementation of vitamin D in all E.N.T. patients not responding to conventional treatment is worth trying. At place of sun screen, use of pomegranates and blueberries may be encouraged to prevent sunburn and eliminate Vitamin D deficiency.

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“…The discovery of vitamin D receptors in the nucleus of cells in the immune system enabled research aimed at identifying the role of vitamin D in the homeostasis of the immune system and in disease prevention [4]. Some of these studies suggested that vitamin D supplements could prevent respiratory infections such as AVB [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…It is one of the main reasons for visits in pediatric emergency rooms [3,4], and it is the cause of approximately 17% of hospital admissions at this age [5,6]. According to the Clinical Practice Guideline from the American Academy of Pediatrics, there are annually 100,000 admissions caused by AVB in the United States, with an estimated cost of 1,730 million dollars [7].…”

Section: Introductionmentioning

confidence: 99%

Efeitos da vitamina D na prevenção da bronquiolite viral aguda: revisão sistemática

Rueda

Sarria-Icaza

Scottá

et al. 2015

Sci Med

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Aims: Published evidence suggests that Vitamin D supplementation may have a protective effect on infectious disease of the lower respiratory tract. The objective of this review was to critically appraise the effects of vitamin D intake in the prevention of acute viral bronchiolitis in children. Methods: We searched the databases Medline, EMBASE, Web of Science, LILACS, and Cochrane Central Register of Controlled Trials, until December 2014, using the keywords: "Vitamin D" or cholecalciferol or ergocalciferol and "bronchiolitis, viral" or "viral bronchiolitis" or "bronchiolitides, viral" or "viral bronchiolitides". Studies evaluating the effect of vitamin D intake in the prevention of acute viral bronchiolitis in young children were included. Studies with less than two weeks of intervention and review articles were excluded. Results: The search identified 241 articles, among which 20 articles were selected for full reading and two articles were included in the systematic review, comprising 296 children. No study measured serum levels of vitamin D. One of the included studies was a clinical trial, where the number of episodes of acute viral bronchiolitis was significantly lower in children supplemented with vitamin D (Group I: mean 0.6±0.7 Group II: mean 1.4±0.9; P=0.001). The other, a case-control study, did not find a significant relationship between the occurrence of acute viral bronchiolitis cases and the intake of vitamin D (odds ratio 1.7, 95% confidence interval 0.7-4.0). Conclusions: Current scientific evidence is insufficient to prove clinical benefits of vitamin D in preventing acute viral bronchiolitis.KEY WORDS: vitamin D; bronchiolitis, viral; infant; child. RESUMOObjetivos: Evidências publicadas sugerem que a suplementação da vitamina D pode ter efeito protetor nas infecções do trato respiratório inferior. O objetivo desta revisão foi avaliar os efeitos da ingestão de vitamina D na prevenção da bronquiolite viral aguda em crianças. Métodos: Foram feitas buscas nas bases de dados Medline, EMBASE, Web of Science, LILACS e Cochrane Central Register of Controlled Trials, até dezembro de 2014, usando os descritores "Vitamin D" ou cholecalciferol ou ergocalciferol e "bronchiolitis, viral" ou "viral bronchiolitis" ou "bronchiolitides, viral" ou "viral bronchiolitides". Foram incluídos estudos que avaliaram o efeito da ingesta da vitamina D na prevenção da bronquiolite viral aguda em crianças. Estudos com intervenção menor que duas semanas e artigos de revisão foram excluídos. Resultados: A busca identificou 241 artigos, entre os quais 20 artigos foram selecionados para leitura na íntegra e dois artigos foram incluídos na revisão sistemática, incluindo 296 crianças. Nenhum estudo mediu os níveis séricos de vitamina D. Um dos estudos incluídos foi um ensaio clinico, no qual o número de episódios de bronquiolite foi significativamente menor nas crianças suplementadas com vitamina D (Grupo I: média 0,6±0,7 Grupo II: média 1,4 ±0,9; P=0,001). No outro, um estudo de casos e controles, não se encontrou rel...

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Vitamin D and respiratory health

Cited by 218 publications

References 49 publications

A test of vitamin D benefits on respiratory health mediated through inflammatory markers

A test of vitamin D benefits on respiratory health mediated through inflammatory markers

Vitamin D Deficiency in E.N.T. Patients

Efeitos da vitamina D na prevenção da bronquiolite viral aguda: revisão sistemática

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