Vitamin D and PTH: data from a cross-sectional study in an equatorial population

Queiroz, Natércia Neves Marques de; Melo, Franciane Trindade Cunha de; Resende, Fabrício de Souza; Janaú, Luísa Corrêa; Neto, Norberto Jorge Kzan de Souza; Lemos, Manuela Nascimento de; Virgolino, A.; Oliveira, Maria Clara Neres Iunes de; Alcântara, Angélica Leite de; Moraes, Lorena Vilhena de; David, Tiago Franco; Silva, Wanderson Maia da; Reis, Scarlatt Souza; Santos, Márcia Costa Dos; Souza, Ana Carolina Contente Braga de; Piani, Pedro Paulo Freire; Mourão, Neyla Arroyo Lara; Felício, Karem Miléo; Neto, João Felício Abrahão; Felício, João Soares

doi:10.1530/ec-20-0206

Cited by 5 publications

(5 citation statements)

References 49 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, Salvador, a city located in the northeast of Brazil, had a percentage of vitamin D deficiency or insufficiency very close to Curitiba in the south region. This was demonstrated before in other tropical cities of the north and northeast of Brazil in specific populations of postmenopausal women and older individuals, but for the first time in a healthy population ( 16 , 17 ). Although Salvador has a higher percentage of dark-skinned individuals than Curitiba, these cities had averages of 25(OH)D that were not different from each other.…”

Section: Discussionsupporting

confidence: 66%

Epidemiology of Vitamin D (EpiVida)—A Study of Vitamin D Status Among Healthy Adults in Brazil

Borba

Lazaretti‐Castro

Moreira

et al. 2022

Journal of the Endocrine Society

View full text Add to dashboard Cite

Background There are few studies of 25-hydroxyvitamin D (25OHD) concentrations in healthy adults in Brazil. Objective to estimate the prevalence of vitamin D status and their association with lifestyle, sociodemographic and anthropometric data in three different regions of Brazil. Methods cross-sectional study among blood donors of both genders, living in the cities of Salvador, São Paulo and Curitiba during Summer. Blood samples were collected during the procedure. Serum 25OHD and parathyroid hormone (PTH) were measured in the same laboratory using chemiluminescence immunoassays. Information on lifestyle, sociodemographic and anthropometric was gathered by an interview with a standardized questionnaire. Vitamin D deficiency and insufficiency was defined as 25OHD levels below 20 ng/mL and below 30 ng/mL, respectively. Results 1,004 healthy adults were evaluated with mean levels of 25OHD (28.7 ± 9.27 ng/mL) and PTH (34.4 ± 15.1 pg/mL). The standardized prevalence of vitamin D deficiency and insufficiency was in the study population 15.3% and 50.9%; in Salvador 12.1% and 47.6%, in São Paulo 20.5% and 52.4% and in Curitiba 12.7% and 52.1%, (p = 0.0004). PTH levels were negatively correlated with 25OHD levels. Greater BMI and higher latitude were significant predictors of vitamin D deficiency, whereas skin color (Caucasian), longer duration of sun exposure and current use of dietary supplement were protective. Conclusions This study confirmed the high prevalence of vitamin D deficiency and insufficiency even in the midsummer in a healthy population of Brazil. Vitamin D levels are associated with sun exposure, latitude, BMI, skin color and use of supplements.

show abstract

Section: Discussionsupporting

confidence: 66%

Epidemiology of Vitamin D (EpiVida)—A Study of Vitamin D Status Among Healthy Adults in Brazil

Borba

Lazaretti‐Castro

Moreira

et al. 2022

Journal of the Endocrine Society

View full text Add to dashboard Cite

show abstract

“…Additionally, another research revealed that there is a drop in blood 25(OH)D concentrations when body mass index (BMI) increases. This suggests that there is a correlation between low vitamin D levels and obesity [31] . Some of the proposed mechanisms that might explain this phenomenon include reduced exposure to sunlight, changes in the activation of vitamin D, and an increase in the storage of vitamin D in adipose tissue [18,32,33] .…”

Section: Discussionmentioning

confidence: 98%

“…The covariates included in the regression model from [31] had little predictive power, as they were only able to account for 5.4% of the variance in 25(OH)D levels. Exploring the impact of genetic variations on the functioning of the vitamin D receptor (VDR) is an important hypothesis that might provide insights into these findings.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Parathyroid Hormone and Vitamin D Levels among Surgery Outpatient Clinic Attendants in Shifa Medical Complex: A Cross-sectional Study

Alslaibi

2024

ijirms

View full text Add to dashboard Cite

Background: Vitamin D and parathyroid hormone (PTH) play crucial roles in calcium homeostasis and bone metabolism. Understanding their levels and associations in the general population is essential for preventive and therapeutic interventions. Methods: A cross-sectional study was conducted to evaluate PTH and vitamin D levels among the general population. Data were collected over one year. A convenience sampling method was employed, and demographic information and laboratory results were obtained through standardized questionnaires and blood samples. Descriptive and inferential statistics were used for data analysis. Results: A total of 390 participants were included, with a predominance of females (65.9%). The mean age was 50.12 years, ranging from 8 to 89 years. Analysis of PTH levels revealed that 68.5% of participants had elevated levels (>65 pg/mL), while 26.4% had normal levels (15-65 pg/mL), and 5.1% had deficient levels (<15 pg/mL). Vitamin D deficiency was prevalent, with 17.2% severely deficient (<10 ng/mL) and 28.5% moderately deficient (10-15 ng/mL). A significant negative correlation was observed between vitamin D and PTH levels (p < 0.05), indicating higher PTH levels in individuals with severe vitamin D deficiency. Age was significantly associated with PTH levels (p < 0.05), with older individuals (>60 years) exhibiting higher mean PTH levels compared to younger age groups. Conclusion: This study highlights the high prevalence of vitamin D deficiency and its association with elevated PTH levels in the general population. The findings underscore the importance of monitoring and addressing vitamin D status, particularly in older individuals, to mitigate the risk of secondary hyperparathyroidism and related complications. Further research is needed to explore the underlying mechanisms and inform targeted interventions for optimizing vitamin D and PTH levels in diverse populations.

show abstract

“…They have not evaluated DKD. The present study used the large VIDAMAZON database (19), being, as we are aware, the first population-based study to establish the association of higher VD levels with better glycemic control.…”

Section: Discussionmentioning

confidence: 99%

“…The present study used the large VIDAMAZON database, which includes data from over 30,000 individuals and has already provided evidence on other VD aspects (19). We included 1,576 diabetic patients who had their diagnosis confirmed by laboratory data and medical history, but we had no access to their medical records and our laboratory data did not contain antibodies related to type 1 DM and C-peptide.…”

Section: Study Design and Data Collectionmentioning

confidence: 99%

Association Between 25(OH)Vitamin D, HbA1c and Albuminuria in Diabetes Mellitus: Data From a Population-Based Study (VIDAMAZON)

et al. 2021

Self Cite

View full text Add to dashboard Cite

BackgroundThe effect of glycemic control on diabetic kidney disease (DKD) is well known. Recent evidence has suggested that Vitamin D (VD) may have a nephroprotective effect in diabetes, but the relationship between VD, glycemic control, and albuminuria has yet to be clarified.ObjectiveEvaluate the relationship between 25-hydroxy-vitamin D [25(OH)D], HbA1c, and albuminuria in Diabetes Mellitus (DM).Patients and MethodsCross-sectional study with 1576 individuals with DM who had 25(OH)D, HbA1c, and albuminuria levels measured. Patients with abnormal creatinine levels were excluded, in order to avoid interference on VD levels by impaired kidney function.ResultsPatients with HbA1c ≥7% had lower 25(OH)D when compared to patients with HbA1c <7% (29.7 ± 10.2 vs 28.1 ± 9.9 ng/ml, p = 0.003) and 25(OH)D levels seems to predict 1.5% of HbA1c behavior. The 25(OH)D concentrations in patients with normoalbuminuria were higher than the levels observed in those with micro or macroalbuminuria (29.8 ± 9.0 vs 26.8 ± 8.6 and 25.1 ± 7.6, respectively, p = 0.001), patients who had 25(OH)D <20 ng/ml and 25(OH)D <30 ng/ml were at a higher risk of presenting albuminuria [OR = 2.8 (95% CI = 1.6 – 4.9), p<0.001, and OR = 2.1 (95% CI = 1.3 - 4.6), p<0.001, respectively]. In our regression model, albuminuria was influenced by HbA1c (r² = 0.076, p<0.00001) and 25(OH)D (r² = 0.018, p = 0.002) independently.ConclusionOur study found an association between vitamin D levels, HbA1c and DKD. Additionally, our data suggest that the association between urinary albumin excretion and vitamin D levels is independent of glycemic control in patients with diabetes. Even though our patients presented normal creatinine levels, it is necessary further prospective studies to confirm if this association precedes or not the loss of renal function.

show abstract

Vitamin D and PTH: data from a cross-sectional study in an equatorial population

Cited by 5 publications

References 49 publications

Epidemiology of Vitamin D (EpiVida)—A Study of Vitamin D Status Among Healthy Adults in Brazil

Epidemiology of Vitamin D (EpiVida)—A Study of Vitamin D Status Among Healthy Adults in Brazil

Evaluation of Parathyroid Hormone and Vitamin D Levels among Surgery Outpatient Clinic Attendants in Shifa Medical Complex: A Cross-sectional Study

Association Between 25(OH)Vitamin D, HbA1c and Albuminuria in Diabetes Mellitus: Data From a Population-Based Study (VIDAMAZON)

Contact Info

Product

Resources

About