Vitamin D and phenotypes of bronchial asthma

Shebl, Eman; Shehata, S. A.; El-Gabry, Maha Abdel-Kader; Ali, Salah Ahmed; Elsaid, Hanaa H.

doi:10.1016/j.ejcdt.2013.06.006

Cited by 15 publications

(3 citation statements)

References 25 publications

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“…Lower 25(OH)D levels are associated with worse lung function, higher levels of exhaled NO, higher serum IgE level, and more changes in HRCT. This study is in agreement with that of Eman et al [16] and Abd ElAety et al [17] who noted that; there was a positive correlation between 25(OH)D levels and FEV 1 %.…”

Section: Discussionsupporting

confidence: 93%

Vitamin D and markers of airway inflammation in asthma

Samaha

Elsaid

NasrEldin

2015

Egyptian Journal of Chest Diseases and Tuberculosis

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Background: Vitamin D plays a role in the pathogenesis of asthma as it has a potent immunomodulatory effect acting on the cells of innate immunity. In asthmatic children low vitamin D levels are associated with poor asthma control, reduced lung function, increased medication intake, and exacerbations. Little is known about vitamin D in adult asthma patients or its association with asthma control and inflammatory markers of asthma.Objective: To establish the relationship between vitamin D serum levels, pulmonary function, asthma control, IgE level and exhaled FE No .Methods: This study comprised 55 subjects (15 healthy volunteers, 40 asthmatic patient) who underwent history taking, HRCT, pulmonary function test, FE NO , total serum IGE level and serum 25(OH)D 3 level.Results: Vitamin D deficiency and insufficiency were observed in uncontrolled asthmatic patients. Patients with vitamin D deficiency and insufficiency had lower pulmonary function, higher serum IgE level, FE NO and higher number of exacerbations in the last year. Total serum IgE level, FE NO , and number of exacerbations showed a negative correlation with serum 25(OH) vitamin D. Serum 25(OH)vitamin D showed a significant positive correlation with pulmonary function in asthmatic patients.Conclusion: The lower the vitamin D level deficiency or insufficiency, the more the asthma exacerbation, the less the asthma control, the higher the serum level of IgE and higher FE NO . Also low vitamin D associated with airway remodeling is presented by small airway affection and HRCT findings.

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Section: Discussionsupporting

confidence: 93%

Vitamin D and markers of airway inflammation in asthma

Samaha

Elsaid

NasrEldin

2015

Egyptian Journal of Chest Diseases and Tuberculosis

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“…Kranam et al [15] conducted a cross-sectional study of 60 children with asthma and concluded that hypovitaminosis D is frequent in children with asthma and is associated with exacerbations, decreased lung functions, and severe disease. A study conducted by Shebl et al [16] concluded that Vitamin D deficiency was highly prevalent in asthmatic patients which was similar to the results of our study. Our results were in concordance with a study conducted by Khan et al which also observed a similar correlation between vitamin D3 levels and asthma control [17].…”

Section: Discussionsupporting

confidence: 92%

Assessment of the Relation Between Asthma Severity and Serum Vitamin D Levels: A Cross-Sectional Study

Kaur,

Kumar,

Singh

et al. 2023

Cureus

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IntroductionVitamin D3's importance for bone health in children and its potential role beyond musculocutaneous health is an ongoing area of research. This study assesses vitamin D3 deficiency prevalence in asthmatic children and its correlation with asthma cases and healthy controls. MethodsThis cross-sectional study was conducted in a tertiary care hospital in Punjab, India among children between 5 and 15 years of age. Fifty children diagnosed with "bronchial asthma" who were under follow-up in the asthma clinic in outpatient and inpatient patients were enrolled as cases. Age-matched 50 healthy controls who presented for routine check-ups were enrolled in the control group. Demographic details were noted and clinical examination was done in all the cases. 25-(OH) vitamin D levels were estimated and compared in all cases and controls. The study also analyzed the relationship between 25-(OH) vitamin D levels with asthma control and severity. ResultsThe study showed that serum vitamin D3 level was significantly decreased in asthmatic children (24.62 ± 14.95 ng/ml) as compared with the healthy control group (32.08 ± 12.22 ng/ml). Also, serum vitamin D3 level was significantly decreased in children with uncontrolled asthma (12.06 ± 4.68 ng/ml) as compared to children with well-controlled asthma (44.82 ± 10.48 ng/ml). ConclusionThe findings showed that low serum levels were observed more in asthmatic children as compared to healthy children. A correlation was also found between vitamin D3 levels and asthma severity, its control, and the number of acute exacerbations in the last year.

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“…This study is also in agreement with that of EmanShebl et al (10) ., who Conducted a study on 66 non-smoking adult asthmatic patients and 30 healthy adult volunteers and found that 40% asthmatic patients suffered from vitamin D insufficiency, while in the control group vitamin D insufficiency was present in 20%, with a significant increase in the number of severe asthmatic patients with vitamin D insufficiency compared with those with sufficient vitamin D. Also Stephanie Korn et al (11). studied serum vitamin D levels in 280 adults with asthma and found that, vitamin D levels in adult asthmatics were low and vitamin D insufficiency or deficiency was significantly related to asthma severity.…”

Section: Asthma In Between Attacksupporting

confidence: 94%

Vitamin D Deficiency and Its Effect on Severity of Asthma in Adult Patients

Solanki¹,

Suthar²,

Chaudhary³

et al. 2020

IJABMS

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AIM: This study is aimed to assess vitamin D status in asthmatic patients and to assess the relationship between vitamin D level and asthma severity. INTRODUCTION:Asthma is heterogeneous disease, usually characterized by variable airflow obstruction and bronchial hyper-responsiveness. The world health organization stated that approximately 300 million people have asthma. Recently the effects of vitamin D appear to have regulatory effect on every part of immune system, vitamin D deficiency being linked to an array of immunologically based disease focusing on asthma. METHOD:The present study included 50 patients diagnosed as bronchial asthma. The asthmatic patient group was divided into group A, asthma in between attack and group B, exacerbated asthma, that was again divided in subgroup (I), (II), and (III) mild , moderate and severe exacerbated asthma according to symptoms and FEV1. Serum 25 hydroxy vitamin D3 level in all groups was measured by radio immunoassay method and compared between these groups. RESULT:This study shows statistically significant correlation between vitamin D level and severity of asthma. The mean levels of serum 25 hydroxy vitamin D3 in asthmatic patients are: Group A-28.24 ± 1.35 ng/ml, mild persistent-22.6 ± 11.5 ng/ml, moderate persistent -18.33 ± 1.31 ng/ml, and severe persistent -10.45 ± 1.84 ng/ml. P value is <0.01, which is highly significant. CONCLUSION:Lower level of vitamin D is associated with higher severity of asthma. Keyword: VITAMIN D DEFICIENCY, SEVERITY OF ASTHMA, ADULT ATIENTS INTRODUCTION:Asthma is heterogeneous disease, usually characterized variable airflow obstruction, chronic airway inflammation and bronchial hyper-responsiveness (1). Until recently bronchospasm was considered cardinal feature of asthma but now in addition to bronchospasm, airway inflammation is recognized as an essential component of the disease. Asthma prevalence is rising in both the developed and developing world with >3 million people affected worldwide (2,3) . Vitamin D is fat soluble nutrient and a secosteroid hormone produced endogenously in the skin from sun exposure or obtained from foods that naturally contain vitamin D including cod liver oil. Vitamin D deficiency is diagnosed by the concentration of blood S.25 (OH) D3 (vitamin D) level, the primary circulatory form of vitamin D and then 1, 25(OH) D3. Low serum level of vitamin D has been linked to increased risk of asthma exacerbation in children and adults.

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Vitamin D and phenotypes of bronchial asthma

Cited by 15 publications

References 25 publications

Vitamin D and markers of airway inflammation in asthma

Vitamin D and markers of airway inflammation in asthma

Assessment of the Relation Between Asthma Severity and Serum Vitamin D Levels: A Cross-Sectional Study

Vitamin D Deficiency and Its Effect on Severity of Asthma in Adult Patients

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