Vitamin D and LL-37 in cirrhotic patients with culture-positive spontaneous bacterial peritonitis

Zeid, Ahmed; Salem, Perihan; Hadidi, Abeer S El; Ibrahim, Tamim G

doi:10.4103/ejim.ejim_102_18

Cited by 2 publications

(5 citation statements)

References 36 publications

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“…Both SBP subgroups receiving and not receiving Vit-D had significantly higher levels of ALP than the control group. In agreement with our result Zeid et al [16] who showed a significant increase in ALP activity among cirrhotic individuals with SBP compared to individuals with simple ascites. Furthermore, our results revealed that ALT was considerably lower in SBP receiving Vit-D compared to non-SBP control group.…”

Section: Discussionsupporting

confidence: 94%

“…Also, a highly significant thrombocytopenia was observed in SBP not receiving Vit-D compared to the non-SBP control group. The present results are in harmony with Zeid et al [16] because individuals with SBP showed an extremely substantial thrombocytopenia as compared to the group with simple ascites. Besides, the ascitic PMN count was significantly higher in group I and SBP-receiving or not Vit-D subgroups than in the non-SBP control group.…”

Section: Discussionsupporting

confidence: 93%

“…Moreover, WBCs were significantly elevated in SBP receiving and not receiving Vit-D compared to non-SBP control group. Zeid et al [16] results are similar to ours where a significant increase in WBCs count was observed when comparing patients with SBP to those without SBP.…”

Section: Discussionsupporting

confidence: 88%

“…The risk factors of SBP in ascetic cirrhotic patients include lower platelet counts, higher WBC counts, higher TSB, lower prealbumin (PA), lower serum ALB, higher Child-Pugh and MELD scores, lower Vit-D and LL-37 levels. This observation was also reported by Zeid et al [16] based on the univariate analysis of different studied parameters. Only reduced Vit-D levels were shown to be substantially correlated with the incidence of SBP when these factors were employed in a multivariate linear regression analysis.…”

Section: Discussionsupporting

confidence: 86%

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Is Vitamin D Deficiency a Risk Factor for Spontaneous Bacterial Peritonitis?

2024

The Egyptian Journal of Hospital Medicine

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Background: Spontaneous bacterial peritonitis (SBP) is a severe worldwide liver condition. Objective: The aim of this study was investigating the association between serum 25(OH)D deficiency and the complications of hepatitis c virus (HCV) related cirrhosis, notably, SBP. Patients and Methods: This prospective case control study was carried out on 100 patients, with cirrhosis and ascites. The patients were divided into two groups: Group I cirrhotic patients with ascites and SBP, which were divided into two equal subgroups according to addition of 25(OH)D to treatment of SBP: group Ia did not receive vitamin D and group Ib received vitamin D. Group II: cirrhotic patients with simple ascites and without SBP. Group Ib of patients were receiving a dose of 2.000 I. U of 25 hydroxycholecalciferol per day for at least 1 week. Results: There was a significant correlation between serum vitamin D and end-stage liver disease (MELD) score (r = -0.51, P= 0.012; r = -0.37, P= 0.016, respectively) in subgroup (GI a) not receiving vitamin D and control group. Serum level of vitamin D was also significantly correlated with ascitic polymorphonuclear neutrophils (PMN) count (cell/µL) in both SBP subgroups (GI a and b) (r = -0.61, P= 0.002; r = -0.61, P= 0.002, respectively). The receiver operating characteristic (ROC) curve analysis estimated a sensitivity of 78.3%, a specificity of 69.0%, a positive predictive value (PPV) of 58%, a negative predictive value (NPV) of 85.3% and an accuracy of 73.7% at the best cutoff value of ≤13.96 (ng/mL). The AUC was 0.76 with a highly significant P-value < 0.001. A positive highly significant correlation between serum vitamin D and serum albumin was observed in both subgroups and control (r = 0.67, P = 0.001 and r =0.50, P=0.014, r = 0.44, P=0.004, respectively). Conclusions: MELD scores >15 were related with an increased risk of SBP. It was also shown that Escherichia coli and Staph aureus were the most frequent bacteria among SBP patients.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 86%

See 2 more Smart Citations

Is Vitamin D Deficiency a Risk Factor for Spontaneous Bacterial Peritonitis?

2024

The Egyptian Journal of Hospital Medicine

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“…First, genetic variants, such as NOD2 and TLR2 gene polymorphism (2), and vitamin D deficiency are significantly associated with spontaneous bacterial peritonitis (3) and contribute to additional susceptibility to SBP; such risk factors should have been matched before randomization process to avoid any selection bias. Moreover, serum ascites vitamin D gradient could be used as a potential biomarker of SBP.…”

mentioning

confidence: 99%