Vitamin D and inflammation: evaluation with neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio

Abstract

IntroductionAssociation of vitamin D, inflammation and endothelial dysfunction, beside the classic bone metabolism disorders, may explain the pathogenesis of numerous diseases associated with vitamin D deficiency. While large numbers of reports support the relationship of vitamin D with inflammation, several reports fail to confirm this relationship. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are novel and inexpensive markers of inflammation that can be studied in all centers. The goal of this study was to investigate the association between 25-hydroxy vitamin D (25(OH)D) and inflammation with the novel inflammatory markers NLR and PLR.Material and methodsThis study was performed retrospectively. Results of the simultaneously performed 25(OH)D, parathyroid hormone, albumin, calcium, phosphorus, alkaline phosphatase and creatinine level measurements and complete blood count were recorded. The data of 4120 patients were included in the study.ResultsBetween vitamin D deficient and non-deficient groups there were significant differences in PLR (p < 0.001) and NLR (p = 0.001). Vitamin D had a significant negative correlation with PLR (p < 0.001) and NLR (p < 0.001). Multiple regression analysis indicated that 25(OH)D was independently and negatively correlated with PLR (OR = 0.994, 95% CI 0.991–0.998, p = 0.02).ConclusionsPlatelet-to-lymphocyte ratio and NLR were significantly associated with 25(OH)D levels, and PLR was found to be an independent predictor of 25(OH)D levels. Our study revealed an inverse association of vitamin D levels and inflammation with these inexpensive and universally available markers.

Is there a relation between vitamin D, interleukin-17, and bone mineral density in patients with inflammatory bowel disease?

“…Ulcerative colitis patients with an affected distal part of the colon had limited inflammation [33,47]. It was shown that vitamin D plays an immunomodulatory role [48,49]. In a study conducted by Chang et al, stimulation of Th17 cells with the help of 1,25D 3 (depending on the concentration) induced expression of the C/EBP homologous protein (CHOP) -a particle involved in endoplasmic reticulum and translation inhibition.…”

The Role of Vitamin D in the Immune System as a Pro-survival Molecule

“…82,83 Recent reports showed that serum levels of vitamin D have a negative correlation with the neutrophil/lymphocyte ratio (P o 0.001) but also with the platelet/lymphocyte ratio (P o 0.001), which is an independent marker of vitamin D deficiency. 84 This evidence suggests an inhibitory role on neutrophil-mediated inflammation exerted by vitamin D and its synthetic analogues (eg, TEI-A00114). 85,86 In patients with inflammatory disorders, such as acute exacerbation of chronic obstructive pulmonary disease, neutrophils undergo apoptosis through the p38MAPK signaling pathway due to the activity of vitamin 1α,25(OH) 2 D 3 .…”

Osteal and extraosteal effects of vitamin D and its opportunities of medication correction of its deficiency

“…Доказанным вкладом в нормализацию артериального давления является подавление витамином D синтеза ренина в клетках юкстагломерулярного аппарата почки [24,49,50]. Было показано, что витамин D уменьшает экспрессию гена ренина через рецептор-зависимый механизм, таким образом, уменьшая концентрации ренина и ангиотензина II, что в итоге приводит к снижению выработки альдостерона и улучшению течения артериальной гипертензии [51,52]. Однако, по данным метаа-…”