Vitamin D and Infertility: The Evidence

Hornstein, Mark D.

doi:10.1142/s266131821950004x

Cited by 7 publications

(8 citation statements)

References 23 publications

(10 reference statements)

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“…One study has reported that vitamin D status was associated with pregnancy outcomes in women undergoing ART, and women with adequate vitamin D levels had a higher live birth rate after ART than those whose vitamin D levels were defined as deficient or insufficient (odds ratio 1.33, 95% confidence interval 1.08-1.65) (Chu et al, 2018). In contrast, other data provided conflicting evidence (Hornstein, 2019). Our finding that vitamin D status had no impact on ongoing pregnancy rates is consistent with a number of previous studies (Fabris et al, 2014;Franasiak et al, 2015;van de Vijver et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Due to the potential impact on implantation, vitamin D might play an important role in determining the outcomes of assisted reproductive technology (ART) treatment, especially given that the rate of vitamin D deficiency in individuals of reproductive age is high (Chu et al, 2018;Gordon et al, 2004;Sullivan et al, 2005;Tangpricha et al, 2002). However, the effects of vitamin D levels on ART outcomes are not well understood (Hornstein, 2019). Recent evidence suggests that women with adequate vitamin D levels might have higher clinical pregnancy and live birth rates (Chu et al, 2018;Zhao et al, 2018), while earlier studies found no impact of vitamin D levels on ART outcomes (Aleyasin et al, 2011;Anifandis et al, 2010;Fabris et al, 2014;Firouzabadi et al, 2014;Franasiak et al, 2015;Liu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Association between Vitamin D Levels and Fertility Outcomes in Patients Undergoing IVF/ICSI

Ha¹,

Pham²,

Vuong

2020

FandR

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Background: Several studies have demonstrated that vitamin D (vitD) might play an important role in the reproductive system due to expression of vitD receptor and vitD-metabolizing enzymes in many reproductive tissues. VitD deficiency has been associated with increased risk of obstetric complications. However, the effect of vitD levels on in vitro fertilization (IVF)/ICSI outcomes is not fully understood. Evidence shows that women with adequate vitD levels might have higher pregnancy rates. This study evaluated the association between serum vitD levels and IVF/ICSI outcomes. Methods: This multicenter, retrospective cohort study was conducted at IVFMD, My Duc Hospital and IVFMDPN, My Duc Phu Nhuan Hospital, Ho Chi Minh City, Vietnam between November 2017 and July 2019. Vietnamese patients aged 18-40 years with serum vitD (25(OH)D) samples collected before starting controlled ovarian stimulation and undergoing embryo transfer were eligible. Patients were divided into four groups based on 25(OH)D levels: <10 ng/mL, 10 to <20 ng/mL, 20 to <30 ng/mL, and ≥30 ng/mL. The primary outcome was ongoing pregnancy rate. Results: Of 3779 patients recruited, 25(OH)D levels were <10 ng/mL in 564 (14.9%), 10 to <20 ng/mL in 436 (11.5%), 20 to <30 in 1,142 (30.2%), and ≥30 ng/mL in 1,637 (43.3%). Ongoing pregnancy rates were similar across the four subgroups (36%, 40%, 36%, and 36%, respectively; p 0.409). The number of oocytes retrieved, embryos, clinical pregnancy, implantation, and miscarriage rates did not differ significantly between subgroups. Conclusions: In this analysis, serum vitD levels did not appear to be correlated with pregnancy outcomes in patients undergoing IVF/ICSI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between Vitamin D Levels and Fertility Outcomes in Patients Undergoing IVF/ICSI

Ha¹,

Pham²,

Vuong

2020

FandR

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“…Treatment with CIDR + gr produced a significantly greater P4 peak compared to CIDR gr starting on the 7th, 9th, 11th, 13th, and 15th days through the experiment. This obtained findings about the greater P4 concentrations in CIDR + gr than in CIDR gr could be explained that vitamin D plays a role in reproduction due to vitamin D receptors were found in the ovary, uterus, and endometrium ( Muscogiuri et al, 2017 ; Hornstein, 2019 ) and it increases the secretion of ovarian P4 secretion through the stimulation of 3β-HSD expression in ovary granulosa cells ( Muscogiuri et al, 2017 ; Farahavar et al, 2020 ).…”

Section: Resultsmentioning

confidence: 82%

“…The precise role of vitamin D is the regulation of calcium and phosphorus metabolism. Recently it is been reported that vitamin D plays a role in reproduction as there are vitamin D receptors in female reproductive organs such as ovaries, uterus, and endometrium ( Muscogiuri et al ., 2017 ; Hornstein, 2019 ). Also, phosphorus deficiency causes irregular estrus and anestrus and decreases the production of ovarian follicles which in turn decreases fertility and conception rate ( Ahuja and Parmar, 2017 , Muscogiuri et al ., 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of vitamin AD3E treatment before application of controlled intra-vaginal drug releaser (CIDR) on clinical and hematologic findings, ovarian hormones and calving rates in she camels (Camelus dromedarius)

Mohamed¹,

Khalphallah²,

Ali³

et al. 2022

Open Vet J

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Background: The scope of using controlled intra-vaginal drug releasers (CIDR) in the camel industry was small relative to that of cow, sheep, and goat. Aim: The purpose of the present study was to determine the effects of intramuscular injection of AD3E (25ml/400kg; QA11CB, Merial, France) as a premedication protocol before CIDR treatment on ovarian hormones profile and calving rate in dromedary she camels (Camelus dromedarius) through measuring concentrations of progesterone (P4) and estradiol (E2) before, during and after CIDR use. Methods: The study was conducted on she-camels (Camelus dromedarius) (n=24) aged between 6-14 years. The animals were assigned into two equal groups; CIDR treated group (CIDRgr) and AD3E plus CIDR treated group (CIDR+gr). Results: Except for haemoglobin, the clinical and haematological findings showed no remarkable change either within each independent group or between CIDRgr and CIDR+gr. Serum P4 and E2 concentrations differed significantly between the first 7 days (During CIDR use) and days from 9 to 15 (After CIDR use) in dromedary camels. Serum concentrations of P4 and E2 showed significant elevation at CIDR+gr at day 0 comparing with CIDRgr. This significant increase in serum of P4 and E2 at CIDR+gr comparing to those of CIDRgr was also observed either during CIDR use (Days 3, 5 and 7) or after CIDR use (Days 9, 11, 13 and 15). During CIDR use, serum concentrations of P4 were negatively correlated with those of E2 either in CIDRgr or in CIDR+gr, however, they were positively correlated after CIDR removal either in CIDRgr or in CIDR+gr. Regarding to the calving rate, it was highest in CIDR+gr whereas CIDRgr showed the lowest one. Conclusions: It was concluded that the AD3E pretreatment protocol of she-camels before insertion of CIDR could be used successfully during the breeding season to improve fertility in she-camels whereas the serum ovarian hormones profile and calving rates were clearly changed due to pretreatment of she-camels with AD3E before CIDR insertion.

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“…The findings can postulate that VD supplementation is unlikely to improve AMH production. As proposed by various molecular characterization studies, VD receptor polymorphism did not lead to subfertility [20][21]. Hence, labelling VDD as a cause of subfertility is unjustifiable.…”

Section: Discussionmentioning

confidence: 88%

A Cross-Sectional Evaluation of Vitamin D Status and Ovarian Reserve Markers in Subfertile Women: A Single-Center Experience From Pakistan

Ahmed¹,

Siddiqui²,

Qureshi³

et al. 2022

Cureus

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This study was conceived with the objective of assessing the correlation between ovarian reserve markers and vitamin D deficiency (VDD) in a selected group of Pakistani subfertile women presenting at a specialized subfertility treatment centre. The measurements of antral follicle count (AFC), serum anti-Müllerian hormone (AMH), serum follicle-stimulating hormone (FSH), and serum vitamin D (VD) levels were the main tools used for the assessment of ovarian reserve. Materials and methodsAll female patients aged 18 to 45 years presenting with primary and/or secondary subfertility at the Australian Concept Medical Centre in Karachi, Pakistan from August 2016 to July 2021 were included in the study. The data of all eligible patients were recorded in the pre-defined Performa designed for this study. The Kruskal-Wallis test was applied to report the distribution of the data. The correlation between the categorical variables (25-hydroxyvitamin D [25-OHD] levels with AFC and AMH) was assessed using the chi-square test and Spearman correlation. The comparison was based on vitamin D levels grouped into three categories: deficiency (<20 ng/ml), insufficiency (21-29 ng/ml), and sufficiency (>30 ng/ml). ResultsOne hundred ninety-nine cases were evaluated for AFC and hormone analysis. The mean age and BMI were 32.87±5.49 years and 28.27±4.97 kg/m 2 . VDD was noted in 127 (68.4%) cases. No significant difference was noted across BMI, age, duration of subfertility, AMH, and FSH across the VD categories. Moreover, a poor correlation was noted between VD, AMH and FSH on the scatter plot, between VD and FSH (r = −0.003, p = 0.966) and between VD and AMH (r = −0.068, p = 0.342), respectively. ConclusionsThis study showed a high frequency of VDD in Pakistani subfertile women, from a specialized subfertility center in the largest metropolis in the country. However, a statistically significant association was not found between the markers of ovarian reserve and VD, showing no ethnic differences in the native Pakistani population. Hence, VD supplementation is unlikely to have an impact on correcting the ovarian reserve status in subfertile women in Pakistan. However, this is a potential area of interest, and evaluation of other indices of reproduction/ovarian reserve and the effect of confounders is required to test this hypothesis longitudinally.

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Vitamin D and Infertility: The Evidence

Cited by 7 publications

References 23 publications

Association between Vitamin D Levels and Fertility Outcomes in Patients Undergoing IVF/ICSI

Association between Vitamin D Levels and Fertility Outcomes in Patients Undergoing IVF/ICSI

Impact of vitamin AD3E treatment before application of controlled intra-vaginal drug releaser (CIDR) on clinical and hematologic findings, ovarian hormones and calving rates in she camels (Camelus dromedarius)

A Cross-Sectional Evaluation of Vitamin D Status and Ovarian Reserve Markers in Subfertile Women: A Single-Center Experience From Pakistan

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