Vitamin D and Diabetes Mellitus: A Review

Souza, Cintia Linhares e; Sá, Larissa Bianca Paiva Cunha de; Rocha, Denise Rosso Tenório Wanderley; Arbex, Alberto Krayyem

doi:10.4236/ojemd.2016.61001

Cited by 5 publications

(5 citation statements)

References 8 publications

(15 reference statements)

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“…Insulin secretion is considered as a calcium-dependent process that is mediated by 1,25(OH) 2 D with the addition of parathyroid hormone (PTH). It has also been punctuated that serum 25(OH)D deficiency and consequent increase in PTH may cause difficulties in the capacity of β cells to convert pro-insulin to insulin, and diabetes may develop with apoptosis of cells [ 31 ]. The deficiency of vitamin D has been ascribed to boosted insulin resistance, to reduced insulin production, and also to metabolic syndrome 1 .…”

Section: Resultsmentioning

confidence: 99%

Vitamin D, the immune system, and its relationship with diseases

Şanlıer¹,

Guney-Coskun

2022

Egypt Pediatric Association Gaz

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Background Vitamin D is classified as an immunomodulatory hormone that is synthesized because of skin exposure to sunlight. It is known to come into play during the regulation of hormone secretion, immune functions, cell proliferation, and differentiation. Its deficiency can cause many diseases and their associated pleiotropic effects. In addition, in relation to its eminent function as regards adaptive immune response and innate immune response, vitamin D level is associated with immune tolerance. Methods Literature search prior to May 2021 was conducted through selected websites, including the MEDLINE, Embase, Web of Science, Cochrane Central, www.ClinicalTrials.gov, PubMed, Science Direct, Google Scholar, and EFSA. Results Vitamin D is found effective for the regulation of hormone secretion, immune functions, and cell proliferation along with differentiation. Its role as an immune modulator is based on the presence of receptors on many immune cells and the synthesis of its active metabolite from these cells. Vitamin D, an immune system modulator, inhibits cell proliferation and stimulates cell differentiation. A fair number of immune system diseases, encompassing autoimmune disorders alongside infectious diseases, can occur because of low serum vitamin D levels. Supplementation of vitamin D has positive effects in lessening the severity nature of disease activity; there exists no consensus on the dose to be used. Conclusion It is figured out that a higher number of randomized controlled trials are essential to evaluate efficacy pertaining to clinical cases, treatment duration, type, and dose of supplementation and pathophysiology of diseases, immune system functioning, and the effect of vitamin D to be administered.

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Section: Resultsmentioning

confidence: 99%

Vitamin D, the immune system, and its relationship with diseases

Şanlıer¹,

Guney-Coskun

2022

Egypt Pediatric Association Gaz

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“…By lowering insulin resistance, raising insulin production, and reducing autoimmune in ammation, vitamin D lowers the risk of developing diabetes types 1 and 2. Therefore, it is feasible that early vitamin D supplementation could provide protection against the onset of DM (Souza et al, 2016Hu et al, 2019Fathi et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

The Helpful Effect of Vitamin D and Coconut Oil in Modulating the Histological Disorders of the Splenic Tissue in Hyperglycemic Mice

El-Desouki

Salem

Afifi

et al. 2023

Preprint

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The present study aims to study the effect of vitamin D (Vit D) or / and coconut oil (Coc) on the splenic histological changes of diabetic adult mice induced by STZ. The mice were divided into 7 groups, and the experimental duration was 4 weeks. GpI: control group without any treatments; GpII&GpIII: non-diabetic groups orally received Vit D in a dose of 500 IU (6.25 ml)/kg b.w/d or Coc in a dose of 7.5 ml /kg b.w/d; GpIV: diabetic group injected i.p. with a single dose of STZ (200 mg/kg bw); Gps V,VI &VII: administration of Vit D or Coc or both together to diabetic group. The results recorded: GpII&GpIII no significant changes in the blood glucose (BG), insulin&splenic weight levels. GpIV had a significant increase in BG, significant decrease in insulin & splenic weight values. GpV recorded a modest decrease in BG, and a modest rise in insulin & a marked splenic weight atrophy; while GpVI or GpVII registered a marked decrease in BG, a rise in insulin levels & a marked splenic weight increment. Histologically, the splenic sections of control or non-diabetic mice received either Vit D or Coc demonstrated normal structure of the splenocytes. GpIV showed great numbers of giant cells, disarrangement and interference of red and white pulps, and dilated congested blood vessels. Little improvement was seen in GpV while GpVI or GpVII showed a marked improvement in the splenic tissues. In conclusion, diabetic mice received either Coc or co-dministered with Vit D demonstrated strong anti-hyperglycemic effects to recovery the glucose and insulin rates to typical levels, and restored the splenic weight and histological architecture to normal status than those given Vit D alone.

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“…The results of many in vivo and in vitro studies indicate that vitamin D deficiency is also associated with an increased risk for respiratory diseases [18], or certain cancers [19]. Obesity [20] and other metabolic syndrome components [21], type 2 diabetes mellitus [22], sarcopenia [23], polycystic ovary syndrome and other gynecological and obstetric diseases [17], and depression [24] are also disorders related to vitamin D deficiency.…”

Section: Introductionmentioning

confidence: 99%

Determinants of Dietary Vitamin D Intake in Population-Based Cohort Sample of Polish Female Adolescents

Lachowicz

Stachoń

2022

IJERPH

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Vitamin D has a pleiotropic effect and its deficiency is a risk factor for many diseases. The purpose of this study was to analyze the dietary intake of vitamin D and the factors determining this intake by female post-primary school students in Poland. The study was conducted on a nationwide sample of 4469 female Polish adolescents (aged 14–20) recruited from all regions across Poland. The vitamin D intake was assessed using VIDEO-FFQ (Vitamin D Estimation Only—Food Frequency Questionnaire). The median dietary vitamin D intake was 2.33 μg per day and it was lower than the 15 μg recommended in Poland for more than 98% of the group. The highest vitamin D intake per day was noted for fish (0.52 μg), whereas the lowest was noted for fats (0.04 μg). Factors that influenced the dietary vitamin D intake were the amount and species of fish consumed, region of residence, use of vitamin D supplements, and vegetarian or vegan diets. In contrast, vitamin D intake did not depend on body mass index and age. Based on the results of the survey, it can be concluded that the alarmingly low intake of vitamin D by Polish female adolescents is a result of the limited supply of vitamin D primarily from fish and fish products. This may be due to insufficient nutritional knowledge, indicating an urgent need to educate the surveyed population in this area.

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Vitamin D and Diabetes Mellitus: A Review

Cited by 5 publications

References 8 publications

Vitamin D, the immune system, and its relationship with diseases

Vitamin D, the immune system, and its relationship with diseases

The Helpful Effect of Vitamin D and Coconut Oil in Modulating the Histological Disorders of the Splenic Tissue in Hyperglycemic Mice

Determinants of Dietary Vitamin D Intake in Population-Based Cohort Sample of Polish Female Adolescents

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