Vitamin D and Depression in Women: A Mini-review

Boulkrane, Mohamed Said; Fedotova, Julia; Kolodyaznaya, V.S.; Micale, Vincenzo; Drago, Filippo; Tol, Annemieke J. M. van den; Baranenko, Denis

doi:10.2174/1570159x17666191108111120

Cited by 19 publications

(13 citation statements)

References 157 publications

(159 reference statements)

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“…Indeed, dietary aspects and diet components (ex. vitamin D, folate, selenium intake, iron, vitamin B12, vitamin K, fiber intake, zinc) as well as diet-related inflammatory potential have been linked to depression outcomes [ 161 , 208 , 236 , 312 , 396 , 402 , 403 , 404 , 405 , 406 , 407 , 408 , 409 , 410 , 411 , 412 , 413 , 414 , 415 , 416 , 417 , 418 , 419 , 420 , 421 , 422 , 423 , 424 , 425 , 426 , 427 , 428 ]. A poor diet has been linked to depression through mechanisms such as inflammation [ 428 ].…”

Section: Resultsmentioning

confidence: 99%

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

2021

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Depression is one of the leading causes of disability, and, if left unmanaged, it can increase the risk for suicide. The evidence base on the determinants of depression is fragmented, which makes the interpretation of the results across studies difficult. The objective of this study is to conduct a thorough synthesis of the literature assessing the biological, psychological, and social determinants of depression in order to piece together the puzzle of the key factors that are related to this condition. Titles and abstracts published between 2017 and 2020 were identified in PubMed, as well as Medline, Scopus, and PsycInfo. Key words relating to biological, social, and psychological determinants as well as depression were applied to the databases, and the screening and data charting of the documents took place. We included 470 documents in this literature review. The findings showed that there are a plethora of risk and protective factors (relating to biological, psychological, and social determinants) that are related to depression; these determinants are interlinked and influence depression outcomes through a web of causation. In this paper, we describe and present the vast, fragmented, and complex literature related to this topic. This review may be used to guide practice, public health efforts, policy, and research related to mental health and, specifically, depression.

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Section: Resultsmentioning

confidence: 99%

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

2021

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“…A low level of vitamin D is associated with the development of a wide range of acute and chronic diseases, including calcium metabolism disorders [ 28 ], neuropsychiatric disorders and neurodegenerative diseases [ 29 , 30 ], allergic and autoimmune reactions [ 31 , 32 ], endocrine disorders (including fertility) [ 33 , 34 ], some types of cancer [ 35 ], type 2 diabetes [ 36 ], cardiovascular [ 37 ] and infectious diseases [ 38 ]. Recent studies have also shown the correlation between the level of vitamin D and the severity of affective disorders in patients in the peri- and postmenopausal periods [ 39 , 40 , 41 ]. Vitamin D deficiency significantly complicates the condition of patients with ischemic stroke and increases the risk of cognitive impairment and dementia [ 12 , 42 , 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Double-Edged Sword of Vitamin D3 Effects on Primary Neuronal Cultures in Hypoxic States

Loginova

Mishchenko

Savyuk

et al. 2021

IJMS

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The use of vitamin D3 along with traditional therapy opens up new prospects for increasing the adaptive capacity of nerve cells to the effects of a wide range of stress factors, including hypoxia-ischemic processes. However, questions about prophylactic and therapeutic doses of vitamin D3 remain controversial. The purpose of our study was to analyze the effects of vitamin D3 at different concentrations on morpho-functional characteristics of neuron–glial networks in hypoxia modeling in vitro. We showed that a single administration of vitamin D3 at a high concentration (1 µM) in a normal state has no significant effect on the cell viability of primary neuronal cultures; however, it has a pronounced modulatory effect on the functional calcium activity of neuron–glial networks and causes destruction of the network response. Under hypoxia, the use of vitamin D3 (1 µM) leads to total cell death of primary neuronal cultures and complete negation of functional neural network activity. In contrast, application of lower concentrations of vitamin D3 (0.01 µM and 0.1 µM) caused a pronounced dose-dependent neuroprotective effect during the studied post-hypoxic period. While the use of vitamin D3 at a concentration of 0.1 µM maintained cell viability, preventive administration of 0.01 µM not only partially preserved the morphological integrity of primary neuronal cells but also maintained the functional structure and activity of neuron–glial networks in cultures. Possible molecular mechanisms of neuroprotective action of vitamin D3 can be associated with the increased expression level of transcription factor HIF-1α and maintaining the relationship between the levels of BDNF and TrkB expression in cells of primary neuronal cultures.

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“…Sources of vitamin D vary, examples include, cold-water fish, plants, and animals; however, dietary sources represent only a small percentage of vitamin D that is metabolized (12,13). There are a number of nutritional sources of vitamin D and its different components; these include, vegetables and herbs as a source of VD2 and white meat and fish as a source for VD3 (5). There seems to be reasonable cause to claim the existence of genetic factors as role players in the modulation of vitamin D levels; however, the same meta-analysis found that the primary determinants to vitamin D levels were environmental factors (14).…”

Section: The Importance Of Vitamin Dmentioning

confidence: 99%

Vitamin D and depression... is there an association?

Satei¹,

Babiker²,

Osman³

2022

IJRP

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In this paper, we looked into the effect vitamin D supplementation has on depressive symptoms in different populations. We found that, despite the existence of clear evidence towards the hypothesis, the number of solid studies (meat-analyses) on the topic were rather few and did not cover all populations. With this article, we aim to make it perfectly clear that there exists a need for far more research on the topic. At least 1 study showed that vitamin D had no effect on depressive symptoms, which also necessitates further research. Furthermore, nations, such as the republic of the Sudan, need to establish 'normal' vitamin D levels in their populations. This is also meant to urge such researches into taking place.

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Vitamin D and Depression in Women: A Mini-review

Cited by 19 publications

References 157 publications

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

Double-Edged Sword of Vitamin D3 Effects on Primary Neuronal Cultures in Hypoxic States

Vitamin D and depression... is there an association?

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