Vitamin D and chronic widespread pain in a white middle-aged British population: evidence from a cross-sectional population survey

Atherton, Kate; Berry, Diane J.; Parsons, Tessa J.; Macfarlane, Gary J.; Power, Chris; Hyppönen, Elina

doi:10.1136/ard.2008.090456

Cited by 119 publications

(94 citation statements)

References 43 publications

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“…There is some controversy among the experts as to which levels of 25-hydroxy vitamin D actually constitute deficiency (Holick 2007), but low levels of 25-hydroxy vitamin D have been linked with a higher incidence of chronic pain (Atherton 2009;Benson 2006;Lotfi 2007). Additionally, associations of such diverse types of pain as headache, abdominal pain, knee pain, and back pain with season of the year and latitude may be taken as evidence to suggest that 25-hydroxy vitamin D levels are important in this context (Mitsikostas 1996;Saps 2008;Zeng 2004).…”

Section: Description Of the Conditionmentioning

confidence: 99%

Vitamin D for the treatment of chronic painful conditions in adults

Straube¹,

Derry²,

Moore³

et al. 2009

Cochrane Database of Systematic Reviews

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Section: Description Of the Conditionmentioning

confidence: 99%

Vitamin D for the treatment of chronic painful conditions in adults

Straube¹,

Derry²,

Moore³

et al. 2009

Cochrane Database of Systematic Reviews

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“…Both cases presented with similar complaints of depression, 10,40-42 fatigue, [43][44][45] and muscle aches, 44,[46][47][48] all of which have been previously associated with vitamin D deficiency. However, there are no current studies correlating a loss of smell with vitamin D deficiency.…”

Section: Discussionmentioning

confidence: 98%

A possible correlation between vitamin D deficiency and loss of smell: 2 case reports

Kruse¹,

Cambron

2011

Journal of Chiropractic Medicine

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Objective: The purpose of this report is to present 2 cases of diminished olfaction that improved with increasing serum levels of vitamin D3. Clinical Features: Both patients were under the care of medical and chiropractic physicians for various complaints. A 47-year-old hyposmic woman was diagnosed with vitamin D deficiency who incidentally noticed a progressive return of her sense of smell while taking vitamin D supplements as prescribed by her medical doctor. A 34-year-old anosmic woman noticed a direct relationship with her ability to smell and vitamin D3 supplementation. Intervention and Outcome: Treatment for the first patient consisted of vitamin D supplementation of 10 000 IU a day. Her serum D3 levels increased substantially over a period of 8 months, at which time she reported a marked improvement in her sense of smell. The second patient was prescribed 50 000 IU of vitamin D a week; and she reported an increased ability to smell, although only the strongest of odors. Conclusion: A link between hypovitaminosis D and a diminished sense of smell was noted in these 2 individuals.

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“…In studies, however, it is reported that a low level of vitamin D is a common symptom in those with non-specific and chronic musculoskeletal pain. Especially, the association between low level of vitamin D and pain in osteomalacia is well established (20)(21)(22)(23)(24). Moreover, there are also studies reporting that a definite improvement is seen at the level of pain after vitamin D supplementation in patients with non-specific and chronic musculoskeletal system pain and vitamin D deficiency (25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

The Association between Vitamin D Level and Chronic Pain and Depression in Premenopausal Women

Yılmaz¹,

Bodur²,

Karaca³

2014

Turk J Phys Med Rehab

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Objective: To investigate the association between vitamin D level and non-specific musculoskeletal system pain and depression in premenopausal women. Material and Methods: Two hundred eighteen premenopausal women with common musculoskeletal pain and unknown etiology were included into the study. Levels of pain and depression were respectively measured with 0-10 visual analog scale (VAS) and Beck Depression Inventory (BDI). Levels of serum 25(OH)D, parathormone, alkaline phosphatase, and calcium were also measured. The threshold value of vitamin D was accepted as 20 ng/mL. Patients with 25(OH)D<20 ng/mL were classified as the vitamin D deficiency group (group 1), and those with ≥20 ng/mL were accepted as the vitamin D group within normal limits (group 2). Results: Of 218 participants, 174 (79.8%) were detected with vitamin D deficiency, while 44 (20.2%) were found with a normal level of vitamin D. A statistically significant difference was present between both groups as to VAS and BDI scores (p<0.001 and p=0.001, respectively), although both groups were similar as to age, body mass index (BMI), level of income, duration of complaints, educational status, family type, and profession (p>0.05). Whereas a negative correlation was present between level of vitamin D and VAS and BDI scores, no correlation was detected as to age, BMI, level of income, educational status (p<0.001); duration of complaints, and number of children (p>0.05). Conclusion: Our study indicates that vitamin D deficiency is a frequent finding in premenopausal women with chronic, non-specific musculoskeletal pain and that the level of vitamin D is associated with levels of pain and depression. Key Words: Vitamin D, pain, depression, women Özet Amaç: Premenopozal erişkin kadınlarda, D vitamini düzeyi ile nonspesifik kas-iskelet sistemi ağrısı ve depresyon arasındaki ilişkiyi araştırmak. Gereç ve Yöntemler: Çalışmaya, nedeni belirlenemeyen yaygın kasiskelet ağrısı bulunan 218 premenopozal kadın dahil edildi. Katılımcıların ağrı düzeyi 0-10 Vizüel Analog Skala (VAS) ile depresyon düzeyi ise Beck Depresyon Ölçeği (BDÖ) ile belirlendi. Katılımcıların serum 25(OH) D, parathormon, alkalen fosfataz ve kalsiyum düzeyleri belirlendi. D vitamini sınır değeri 20 ng/mL olarak kabul edildi. 25(OH)D<20 ng/mL olan hastalar D vitamini eksikliği (Grup 1), ≥20 ng/mL olan hastalar ise D vitamini normal (Grup 2) olarak kabul edildi. Bulgular: İki yüz on sekiz katılımcının 174'ünde (%79,8) D vitamini eksikliği saptanırken, 44'ünde (%20,2) D vitamininin normal sınırlarda olduğu tespit edildi. Gruplar yaş, beden kitle indeksi (BKİ), gelir düzeyi, şikayet süresi, öğrenim durumu, aile tipi ve çalışma durumu yönünden benzer iken (p>0,05); VAS ve BDÖ skorları yönünden iki grup arasında istatistiksel olarak anlamlı fark mevcuttu (p<0,001 ve p=0,001, sırasıyla) D vitamini düzeyi ile VAS ve BDÖ skorları arasında negatif korelasyon saptanırken (p<0,001); yaş, BKİ, gelir düzeyi, öğrenim düzeyi, şikayet süresi ve çocuk sayısı arasında korelasyon tespit edilmedi (p>0,05). Son...

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Vitamin D and chronic widespread pain in a white middle-aged British population: evidence from a cross-sectional population survey

Abstract: Current vitamin D status was associated with CWP in women but not in men. Follow-up studies are needed to evaluate whether higher vitamin D intake might have beneficial effects on the risk of CWP.

Cited by 119 publications

References 43 publications

Vitamin D for the treatment of chronic painful conditions in adults

Vitamin D for the treatment of chronic painful conditions in adults

A possible correlation between vitamin D deficiency and loss of smell: 2 case reports

The Association between Vitamin D Level and Chronic Pain and Depression in Premenopausal Women

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