“…Its effects on inflammation (e.g., through inhibition of prostaglandins synthesis, p38 MAPK, and NF-kb signaling), DNA damage repair (e.g., through upregulation of p53, ATM, BRCA1 and other damage repair proteins), modulation of proliferation and differentiation (e.g., through upregulation of CDK inhibitors, activation of FOXO3/4, TGFB signaling), apoptosis, and autophagy are widely recognized. Among these several actions, calcitriol exerts a role in WNT–β-catenin signalling in colon cancer, in estrogens synthesis and signalling in estrogen receptor-positive (ER+) postmenopausal breast cancer, and, moreover, in androgen receptor (AR) signalling in prostate cancer [ 95 ].…”