Vitamin D and Calcium Intakes from Food or Supplements and Mammographic Breast Density

Bérubé, Sylvie; Diorio, Caroline; Mâsse, Benoı̂t; Hébert‐Croteau, Nicole; Byrne, Celia; Côté, Guillaume; Pollak, Michael; Yaffe, Martin J.; Brisson, Jacques

doi:10.1158/1055-9965.epi-05-0068

Cited by 88 publications

(81 citation statements)

References 82 publications

(94 reference statements)

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“…In particular, Cho et al (2004) concluded from an analysis of pooled primary data from 10 cohort studies that optimal risk reduction for colorectal cancer necessitates high intake levels of both vitamin D and calcium. Berube et al (2005) studied the relation of separate and combined intakes of vitamin D and calcium by pre-menopausal women on mammographic breast density as a surrogate marker for breast cancer risk. They found that the negative association between dietary vitamin D intake and breast density tended to be stronger when calcium intake levels were higher and vice versa.…”

Section: Cancermentioning

confidence: 99%

“…The resulting increase in intracellular Ca 2 þ may conceivably activate proapoptotic intracellular signalling, similar to that caused by 1,25-(OH) 2 D 3 (Mathiasen et al, 2002). The effect of the apparent cross-talk between Ca 2 þ /CaR and 1,25-(OH) 2 D 3 /VDR signalling on cytosolic Ca 2 þ may explain, at least in part, how vitamin D and calcium together efficiently regulate neoplastic mammary gland cell growth in vivo (Berube et al, 2005;Lin et al, 2007).…”

Section: Cancermentioning

confidence: 99%

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Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology

Peterlik¹,

Cross²

2009

Eur J Clin Nutr

101

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A compromised vitamin D status, characterized by low 25-hydroxyvitamin D (25-(OH)D) serum levels, and a nutritional calcium deficit are widely encountered in European and North American countries, independent of age or gender. Both conditions are linked to the pathogenesis of many degenerative, malignant, inflammatory and metabolic diseases. Studies on tissue-specific expression and activity of vitamin D metabolizing enzymes, 25-(OH)D-1a-hydroxylase and 25-(OH)D-24-hydroxylase, and of the extracellular calcium-sensing receptor (CaR) have led to the understanding of how, in non-renal tissues and cellular systems, locally produced 1,25-dihydroxyvitamin D 3 (1,25-(OH) 2 D 3 ) and extracellular Ca 2 þ act jointly as key regulators of cellular proliferation, differentiation and function. Impairment of cooperative signalling from the 1,25-(OH) 2 D 3 -activated vitamin D receptor (VDR) and from the CaR in vitamin D and calcium insufficiency causes cellular dysfunction in many organs and biological systems, and, therefore, increases the risk of diseases, particularly of osteoporosis, colorectal and breast cancer, inflammatory bowel disease, insulin-dependent diabetes mellitus type I, metabolic syndrome, diabetes mellitus type II, hypertension and cardiovascular disease. Understanding the underlying molecular and cellular processes provides a rationale for advocating adequate intake of vitamin D and calcium in all populations, thereby preventing many chronic diseases worldwide.

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Section: Cancermentioning

confidence: 99%

Section: Cancermentioning

confidence: 99%

Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology

Peterlik¹,

Cross²

2009

Eur J Clin Nutr

101

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“…For example, alcohol has been shown to consistently increase breast cancer risk [1] through many proposed mechanisms, including the alteration of estrogen metabolism and receptor status and increased exposure to harmful metabolites that damage DNA [27•]. Other components of the diet, such as vitamin D and calcium, may influence breast density, which is a strong risk factor for breast cancer [28][29][30]. Also, certain nutrients may be more influential on breast cancer risk only after reaching a threshold that promotes tumor development; thus, the baseline rate of consumption in a population may dictate when associations are observed [31].…”

Section: Discussionmentioning

confidence: 99%

Is Usual Dietary Pattern Related to the Risk of Developing Breast Cancer?

et al. 2013

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Dietary patterns capture total diet providing a more comprehensive understanding of the effect of diet on chronic disease risk. Dietary patterns have been associated with several chronic diseases, including cardiovascular disease and selected cancers; however, the association with breast cancer remains unclear. The objective of this review was to examine critically the most recent literature on dietary patterns and breast cancer and report on current results, new developments, and future directions. Seven case-control and cohort studies from multiple countries have been published during the previous year (2011)(2012). Many have analyzed a posteriori dietary patterns via factor and principal component analysis. Whereas results remain mixed, the majority of studies indicate healthier patterns decrease breast cancer risk, although patterns higher in meat and alcohol increase risk. Future studies that examine the associations between diet and tumor subtypes and collect dietary data at younger ages and, if possible, longitudinally would be beneficial.

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“…Randomized control trials demonstrated changes in breast density with intake of low-fat high carbohydrate diet. 70,71 Cross-sectional studies have shown calcium and vitamin D, [72][73][74][75][76] and vegetables 75,77 to be associated with lower breast density.…”

Section: Breast Composition and Radiographic Appearancesmentioning

confidence: 99%

“…It is also increasingly important that screened women with dense breasts are advised to avoid lifestyles such as alcohol intake and exogenous hormone use that have been shown to increase cancer risk in women with dense breast. Also, consumption of food species associated with lower breast density 22,72,75,77 and physical activity 78 is encouraged as these may mitigate their risk of developing breast cancer.…”

Section: Breast Composition and Radiographic Appearancesmentioning

confidence: 99%

Breast composition: Measurement and clinical use

Ekpo¹,

Hogg²,

Highnam³

et al. 2015

Radiography

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Breast density is a measure of the extent of radiodense fibroglandular tissue in the breast. The risk of developing breast cancer and the risk of missing cancer at screening rise with higher breast density. In this paper, the historical background to breast density measurement is outlined and current evidence based practice is explained. The relevance of breast density knowledge to mammographic practice and image interpretation is considered in the light of clinical assessment and notification of mammographic breast density (MBD). The current work also discusses risk stratification for decisionmaking regarding screening frequency and better modalities for earlier detection of breast cancer in the dense breast. Automated volumetric approaches are explained while ultrasound, digital breast tomosynthesis, molecular breast imaging, and magnetic resonance imaging are introduced as valuable adjuncts to digital mammography for imaging the dense breast. The work concludes on the important note that screened women should be notified of their breast density, and such notification should be accompanied with clear and adequate information about breast density and cancer risk, strategies associated with lower MBD, as well as best screening intervals and pathways for women with dense breasts. Adoption of these strategies may be crucial to early detection and treatment of cancer and improving survival from the disease.

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Vitamin D and Calcium Intakes from Food or Supplements and Mammographic Breast Density

Cited by 88 publications

References 82 publications

Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology

Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology

Is Usual Dietary Pattern Related to the Risk of Developing Breast Cancer?

Breast composition: Measurement and clinical use

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