Vitamin D and Bone Physiology: Demonstration of Vitamin D Deficiency in an Implant Osseointegration Rat Model

Kelly, James; Lin, A. T.; Wang, Chiachien J.; Park, Sil; Nishimura, Ichiro

doi:10.1111/j.1532-849x.2009.00446.x

Cited by 84 publications

(104 citation statements)

References 30 publications

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“…Thus, our vitamin D deficiency model was successfully developed. Previous studies demonstrated that basal levels of vitamin D in rats range from 12 to 20 ng/mL [23], [24]. Moreover, Ismail et al [25] using a 6-week-vitamin D deficiency model in Wistar rats showed that the levels of 25(OH)D were approximately 1.0 ng/mL in vitamin D-deficient animals while control group presented around 20.0 ng/mL.…”

Section: Discussionmentioning

confidence: 97%

Vitamin D Deficiency Aggravates Nephrotoxicity, Hypertension and Dyslipidemia Caused by Tenofovir: Role of Oxidative Stress and Renin-Angiotensin System

et al. 2014

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Vitamin D deficiency (VDD) is prevalent among HIV-infected individuals. Vitamin D has been associated with renal and cardiovascular diseases because of its effects on oxidative stress, lipid metabolism and renin-angiotensin-aldosterone system (RAAS). Tenofovir disoproxil fumarate (TDF), a widely used component of antiretroviral regimens for HIV treatment, can induce renal injury. The aim of this study was to investigate the effects of VDD on TDF-induced nephrotoxicity. Wistar rats were divided into four groups: control, receiving a standard diet for 60 days; VDD, receiving a vitamin D-free diet for 60 days; TDF, receiving a standard diet for 60 days with the addition of TDF (50 mg/kg food) for the last 30 days; and VDD+TDF receiving a vitamin D-free diet for 60 days with the addition of TDF for the last 30 days. TDF led to impaired renal function, hyperphosphaturia, hypophosphatemia, hypertension and increased renal vascular resistance due to downregulation of the sodium-phosphorus cotransporter and upregulation of angiotensin II and AT1 receptor. TDF also increased oxidative stress, as evidenced by higher TBARS and lower GSH levels, and induced dyslipidemia. Association of TDF and VDD aggravated renovascular effects and TDF-induced nephrotoxicity due to changes in the redox state and involvement of RAAS.

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Section: Discussionmentioning

confidence: 97%

Vitamin D Deficiency Aggravates Nephrotoxicity, Hypertension and Dyslipidemia Caused by Tenofovir: Role of Oxidative Stress and Renin-Angiotensin System

et al. 2014

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“…The causes of early implant failure are not fully clarified and an association between vitamin D and dental implant osseointegration has not been investigated properly [8, 13–16]. Some recent animal studies in rodents demonstrated a relationship between vitamin D supplementation and an increased bone to implant contact/volume after implant placement [14, 34, 35]. Mengatto et al demonstrated an impaired osseointegration in vitamin D-deficient rats [36].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency in early implant failure: two case reports

et al. 2016

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An association between vitamin D deficiency and early dental implant failure is not properly verified, but its role in osteoimmunology is discussed. This article illustrates two case reports with vitamin D deficiency and early implant failure. Prior to implant placement, the first patient received crestal bone grafting with autologous material. Both patients received dental implants from different manufacturers in the molar region of the mandible. In the case of bone grafting in the first patient, all implants were placed in a two-stage procedure. All implants had to be removed within 15 days after implant placement. Vitamin D serum levels were measured: Both patients showed a vitamin D deficiency (serum vitamin D level <20 μg/l). After vitamin D supplementation, implant placement was successful in both patients. Prospective, randomized clinical trials must follow to affirm the relationship between vitamin D deficiency, osteoimmunology, and early implant failure.

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“…The high social and health relevance of the phenomenon of osseointegration is clearly observed by the innumerous studies on bone physiology and repair available in literature (Robiony et al, 2008;Kelly et al, 2009), as well as the advanced technology in search of biomaterials (Cowan et al, 2005) in order to promote local bone formation, and make possible the rehabilitation of partially or totally deficient edentulous jaws using dental implants (Aghaloo and Moy, 2007). Although autogenous bone graft is still considered the gold standard material for bone reconstruction, a second surgical approach and morbidity of donor site are the main disadvantages (Cricchio and Lundgren, 2003;Chiapasco et al, 2006).…”

Section: Introductionmentioning

confidence: 97%

Bovine hydroxyapatite (Bio-Oss®) induces osteocalcin, RANK-L and osteoprotegerin expression in sinus lift of rabbits

Chaves¹,

Nunes²,

Oliveira³

et al. 2012

Journal of Cranio-Maxillofacial Surgery

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Vitamin D and Bone Physiology: Demonstration of Vitamin D Deficiency in an Implant Osseointegration Rat Model

Cited by 84 publications

References 30 publications

Vitamin D Deficiency Aggravates Nephrotoxicity, Hypertension and Dyslipidemia Caused by Tenofovir: Role of Oxidative Stress and Renin-Angiotensin System

Vitamin D Deficiency Aggravates Nephrotoxicity, Hypertension and Dyslipidemia Caused by Tenofovir: Role of Oxidative Stress and Renin-Angiotensin System

Vitamin D deficiency in early implant failure: two case reports

Bovine hydroxyapatite (Bio-Oss®) induces osteocalcin, RANK-L and osteoprotegerin expression in sinus lift of rabbits

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