Vitamin D and bone mineral status of newborn-maternal pair delivering at a tertiary hospital in Nigeria

Elechi, Hassan Abdullahi; Oduwole, Abiola; Idris, H. W.; Faruk, MB; Ma, Aijun

doi:10.4103/njcp.njcp_368_20

Cited by 2 publications

(2 citation statements)

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“…The findings showed a statistically significant correlation between the mother's VD and the infant. Other studies that have been done by Shor et al (8) , Esmeraldo et al (16) , Elechi et al (17) , and Wang et al (18) also support the findings in this study. Two studies conducted in Turkey by Ozdemir et al (19) and Fedakar (20) show a robust positive correlation between the mother's and the newborn's VDL and show that minimal maternal VDL was a significant predictor for deficiency in the newborn.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of Vitamin D in Mothers and Newborns at Birth in Sulaimani Maternity Teaching Hospital

Mahmood,

Noori

2023

JSMC

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BackgroundDeficiencies in vitamin D are frequent worldwide. Approximately 1 billion individuals around the globe are vitamin D deficient (<20ng/ml), and half of the population is insufficient (20-29ng/ml). According to extensive epidemiological studies, vitamin D deficiency is common in women, particularly pregnant and nursing mothers. Vitamin D deficiency during pregnancy is associated with various maternal and fetal health effects. ObjectivesVitamin D levels in fetuses and newborns are directly related to their mothers’ levels during pregnancy. The study aims to assess and compare the vitamin D levels of mothers and their newborn babies. Additionally, we are interested in determining whether there is a link between vitamin D levels and delivery outcomes. Patients and MethodsOne hundred pairs of mothers and newborns enrolled in a cross-sectional study at Maternity Teaching Hospital in Sulaimani. Any newborn baby diagnosed with a congenital abnormality during pregnancy was excluded. Also, any mother that was on anticonvulsant drugs was excluded. Blood samples for vitamin D analysis were taken from the mothers and newborns at birth. In addition, the demographic and medical data of the mothers and newborns were recorded. All evaluations had a p-value of 0.05 as the threshold for statistical significance. ResultsThe mothers’ and newborns’ mean vitamin D were 17.2±13.33 ng/ml and 10.48±9.77 ng/ml, respectively. An examination of the data using statistical methods indicated a connection between the vitamin D found in mothers and the levels found in their newborns (p-value=0.001). Furthermore, higher levels during pregnancy were linked to better Apgar scores (≥7) for their newborn children (p-value=0.03). Maternal vitamin D level was not statistically associated with other birth outcomes; p-value > 0.05. ConclusionThe results of this study show that vitamin D deficiency in mothers leads to deficiency in their newborns. Except for the Apgar score, no statistically significant relationship was found between maternal vitamin D levels and other birth outcomes.

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Section: Discussionsupporting

confidence: 91%

Evaluation of Vitamin D in Mothers and Newborns at Birth in Sulaimani Maternity Teaching Hospital

Mahmood,

Noori

2023

JSMC

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“…A 2019 study by Oluwole showed that the prevalence of serum 25(OH)D deficiency was higher among women with preterm delivery than among those with term delivery [ 24 ]. No study, however, has assessed the impact of 25(OH)D and associated metabolites status on pregnancy and newborn outcomes in Nigeria [ 20 , 25 , 26 ]. No studies with the Nigerian populations have looked at associations of maternal-infant vitamin D and metabolite levels with the above risk factors and outcomes.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Metabolites in Mother–Infant Dyads and Associated Clinical Outcomes in a Population of Nigerian Women

Delair,

Anderson-Berry,

Olateju

et al. 2024

Nutrients

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Low levels of vitamin D in maternal and cord blood have been associated with neonatal sepsis. This study assessed the association of vitamin D metabolites (25(OH)D, 3-epi-25(OH)D3, and 24,25(OH)2D3) levels in maternal and cord blood with newborn sepsis evaluation in Nigerian mother–infant dyads. Maternal and cord blood from 534 mothers and 536 newborns were processed using liquid chromatography-tandem mass spectrometry. Spearman correlation was used to compare continuous variables, Mann–Whitney for dichotomous variables, and Kruskal–Wallis for two or more groups. High cord percent 3-epi-25(OH)D3 levels were positively associated with newborn evaluation for sepsis (p = 0.036), while maternal and cord 25(OH)D and 24,25(OH)2D3 levels were not. Being employed was positively associated with maternal and newborn 3-epi-25(OH)D3 concentrations (p = 0.007 and p = 0.005, respectively). The maternal 3-epi-25(OH)D3 and percent 3-epi-25(OH)D3 were positively associated with vaginal delivery (p = 0.013 and p = 0.012, respectively). Having a weight-for-age Z-score ≤ −2 was positively associated with newborn percent 3-epi-25(OH)D3 levels (p = 0.004), while a weight-for-length Z-score ≤ −3 was positively associated with maternal and newborn percent 3-epi-25(OH)D3 levels (p = 0.044 and p = 0.022, respectively). Our study highlights the need to further investigate the biological role of 3-epi-25(OH)D3 and its clinical significance in fetal growth and newborn outcome.

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Vitamin D and bone mineral status of newborn-maternal pair delivering at a tertiary hospital in Nigeria

Cited by 2 publications

References 10 publications

Evaluation of Vitamin D in Mothers and Newborns at Birth in Sulaimani Maternity Teaching Hospital

Evaluation of Vitamin D in Mothers and Newborns at Birth in Sulaimani Maternity Teaching Hospital

Vitamin D Metabolites in Mother–Infant Dyads and Associated Clinical Outcomes in a Population of Nigerian Women

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