Vitamin D and Bone Health

Alvarez, Jessica A.; Tangpricha, Vin

doi:10.1007/978-3-319-16387-1_4

Cited by 2 publications

(2 citation statements)

References 122 publications

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“…Vitamin D, a fat-soluble steroid hormone, plays an important role in regulating a number of biological functions [1]. The Vitamin D precursors, 7-dehydrocholesterol, are formed by ultraviolet irradiation in the skin and transported to liver.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Regulates the Expressions of AQP-1 and AQP-4 in Mice Kidneys

Zhu

Zhang

et al. 2019

BioMed Research International

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Aim. Vitamin D plays an important role in water and salt homeostasis. The aim of our study was to investigate the underlying relationship of Vitamin D and Aquaporins (AQP). Methods. The behaviors of 1α (OH)-ase knockout mice and wild type mice were observed before analysis. The ICR mice were treated with vehicle or paricalcitol, a vitamin D analogue, followed by animals receiving a standard diet and free access to drinking water either with aliskiren (renin blocker; 37.5 mg aliskiren in 100 ml water), or telmisartan (a angiotensin II type I receptor blocker; 40 mg telmisartan in 100 ml water) a week before study. The expressions of AQP-1, AQP-4, and renin in mice kidneys were detected by western bolting, immunohistochemistry, and immunofluorescence. Results. Diuresis and polydipsia were observed in 1α (OH)-ase knockout mice, and a decreased water intake and urine output in ICR mice was observed after paricalcitol treatment. Compared with wild type, the AQP-1 expressions were increased in renal papilla and AQP-4 expressions were decreased in renal proximal tubule of 1α(OH) ase knockout mice. In addition, AQP-1 was decreased in renal papilla and AQP-4 expressions were increased in proximal tubule by suppressing renin activity or supplement of Vitamin D analogue. After injecting renin into the lateral ventricle of the 1α(OH)ase knockout mice, the renin expression level was decreased in the kidney, followed by the decrease of AQP-1 in renal papilla and increase of AQP-4 in proximal tubule. Conclusions. Overall, Vitamin D and renin inhibitors have synergistic effects in regulating water channels in mice kidneys.

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Section: Introductionmentioning

confidence: 99%

Vitamin D Regulates the Expressions of AQP-1 and AQP-4 in Mice Kidneys

Zhu

Zhang

et al. 2019

BioMed Research International

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“…Children and adults with CF should consume 1,000–1,500 mg of elemental calcium in divided doses, preferably from the diet or supplemented with pills to ensure adequate mineralization of the skeleton. Other nutrients such as vitamin K, magnesium, and phosphorus are also important for optimal skeletal health 57 . Excessive alcohol 58 and vitamin A intake 59 should be avoided which may negatively impact bone.…”

Section: Cystic Fibrosis Related Bone Diseasementioning

confidence: 99%

Endocrine Disorders in Cystic Fibrosis

Blackman

Tangpricha

2016

Pediatric Clinics of North America

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Summary Cystic fibrosis can cause multiple endocrine disorders including diabetes, bone disease, short stature, and male hypogonadism. The etiologies are multifactorial but may be directly related in some cases to CFTR dysfunction. Diabetes is the most common endocrine complication and can be expected to affect in almost all people with pancreatic insufficient CF but varies widely in its age of onset. Early identification and treatment of diabetes improves morbidity and mortality in CF. Short stature during adolescence can be transient if puberty is later than average, but it can also be pathologic. Inhaled and systemic steroids can slow growth and should be used at the minimum effective doses. Bone disease in CF is a frequent cause of fragility fractures and associates with worse lung disease. Bone mineral density and vitamin D levels should be monitored. Hypogonadism has been reported in 25% of men with CF. Endocrine complications can cause morbidity and mortality in CF and need to be appropriately detected and managed as part of the medical care of individuals with CF. These complications tend to occur more frequently in older individuals and may be expected to become more common as the CF population grows older.

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Vitamin D and Bone Health

Cited by 2 publications

References 122 publications

Vitamin D Regulates the Expressions of AQP-1 and AQP-4 in Mice Kidneys

Vitamin D Regulates the Expressions of AQP-1 and AQP-4 in Mice Kidneys

Endocrine Disorders in Cystic Fibrosis

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