Vitamin D and body composition in the elderly

Vitezova, Anna; Muka, Taulant; Zillikens, M. Carola; Voortman, Trudy; Uitterlinden, André G.; Hofman, Albert; Rivadeneira, Fernando; Jong, Jessica C. Kiefte‐de; Franco, Oscar H.

doi:10.1016/j.clnu.2016.04.017

Cited by 30 publications

(23 citation statements)

References 48 publications

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“…The result suggested that high body fat percentage contributed the most towards insufficient vitamin D, followed by low consumption of milk and dairy products. A study conducted by Vitezova et al [23] also reported that body fat percentage had the strongest association on the vitamin D level of older women. Previous reviews by Cashman [15] and Lips et al [8] also support that milk and dairy products consumption can improve vitamin D status via the calcium content and vitamin D fortification.…”

Section: Discussionmentioning

confidence: 90%

“…As a result, any extra fat mass gained can become a storage site for the fat-soluble vitamin D in the body [22], which leads to less vitamin D being released into the blood circulation [19]. There are possibilities that the ongoing changes in body composition among older adults and different obesity indicators make the relationship between different anthropometric indices, such as body mass index (BMI), waist circumference and body fat percentage with vitamin D status to be inconsistent [23][24][25][26]. Therefore, it is essential to consider various anthropometric indices that can be utilized to estimate vitamin D status among older adults.…”

Section: Introductionmentioning

confidence: 99%

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High body fat percentage and low consumption of dairy products were associated with vitamin D inadequacy among older women in Malaysia

et al. 2020

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Background Serum vitamin D insufficiency is a public health issue, especially among older women. Sun exposure is fundamental in the production of vitamin D, but older women have less optimal sun exposure. Therefore, factors such as body composition and diet become more essential in sustaining sufficient serum levels of vitamin D. The objective of the current study is to determine factors contributing towards serum vitamin D insufficiency among 214 older women. Methods The respondents had their body weight, height, waist circumference and body fat percentage measured, as well as interviewed for their socio-demographic characteristics, sun exposure and dietary intake. Fasting blood samples were obtained from the respondents to measure their serum 25-hydroxyvitamin D [25(OH)D] concentration. Results There were 82.7% (95% CI: 77.6%, 87.8%) of the respondents that had serum vitamin D insufficiency (< 50 nmol/L) with an average of 37.4 ± 14.3nmol/L. In stepwise multiple linear regression, high percentage of body fat (ß =-0.211, p <0.01) and low consumption of milk and dairy products (ß = 0.135, p <0.05) were the main contributors towards insufficient serum vitamin D levels, but not socio-demographic characteristics, other anthropometric indices, sun exposure and diet quality.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

High body fat percentage and low consumption of dairy products were associated with vitamin D inadequacy among older women in Malaysia

et al. 2020

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“…An accumulating body of evidence suggests that suboptimal vitamin D levels are common and related with the risk of cardiovascular disease (Martini & Wood, ; L. Wang et al, ). Adults studies suggest that low 25(OH)D concentrations are associated with higher BMI and higher fat mass percentage (Jackson et al, ; Vitezova et al, ). In line with these results, studies in animals show that vitamin D influences development and differentiation of adipocytes and muscle cells (Pasco et al, ; Wood, ).…”

Section: Discussionmentioning

confidence: 99%

“…We have previously shown that suboptimal concentrations of maternal vitamin D are associated with low birth weight and small size for gestational age (Miliku et al, ), which are known to be associated with cardiovascular risk factors in the offspring (Horikoshi et al, ; Lawlor et al, ). Studies in adults suggest that vitamin D plays an important role in cardiovascular protection and body composition profile (Vitezova et al, ; T. J. Wang et al, ; Wimalawansa, ). Furthermore, cross‐sectional studies in children have reported associations of lower vitamin D status with higher adiposity measures and cardiovascular risk factors such as blood pressure, plasma lipids, and insulin concentrations (Gilbert‐Diamond et al, ; Petersen et al, ; Williams et al, ).…”

Section: Introductionmentioning

confidence: 99%

Associations of maternal and fetal vitamin D status with childhood body composition and cardiovascular risk factors

Miliku

Felix

Voortman

et al. 2018

Maternal & Child Nutrition

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Maternal vitamin D deficiency during pregnancy may have persistent adverse effects on childhood growth and development. We examined whether 25-hydroxyvitamin D (25(OH)D) concentrations during pregnancy and at cord blood were associated with childhood body composition and cardiovascular outcomes. This study was embedded in a population-based prospective cohort in Rotterdam, The Netherlands, among 4,903 mothers and their offspring. We measured 25(OH)D concentrations at a median gestational age of 20.4 weeks (95% range 18.5-23.4 weeks) and at birth (40.1 weeks [95% range 35.8-42.3 weeks]). 25(OH)D concentrations were categorized into severely deficient (<25.0 nmol/L); deficient (25.0 to 49.9 nmol/L); sufficient (50.0 to 74.9 nmol/L) and optimal (≥75.0 nmol/L). At 6 years, we measured childhood body mass index; fat and lean mass by Dual-energy X-ray Absorptiometry; blood pressure; and serum cholesterol, triglycerides, and insulin concentrations. Compared with children from mothers with optimal 25(OH)D concentrations (≥75.0 nmol/L), those of severely deficient vitamin D (<25.0 nmol/L) mothers had a 0.12 standard deviation score (SDS); (95% Confidence Interval (CI) [0.03, 0.21]) higher fat mass percentage and a 0.13 SDS (95% CI [−0.22, −0.04]) lower lean mass percentage. These associations remained after adjustment for current child vitamin D status. Maternal and cord blood 25(OH)D concentrations were not associated with cardiovascular risk factors in childhood. In conclusion, severe maternal 25(OH)D deficiency (<25.0 nmol/L) duringpregnancy is associated with an adverse childhood body composition profile, but we did not observe evidence for an association with childhood cardiovascular risk factors.Further studies are needed to replicate our findings, to examine the underlying mechanisms, the causality of the associations, and the potential for public health interventions.

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“…Observational studies found serum 25(OH)D associated with different anthropometric measures and body composition measures [13][14][15] . A recent study found that an increase in serum 25(OH)D was associated with 0.23 higher lean mass percentage 16 . However, it is still unclear whether vitamin D status is associated with alterations in body composition, especially in the elderly.…”

Section: Introductionmentioning

confidence: 98%

Muscle strength and muscle mass in elderly women after cholecalciferol supplementation in Southern Brazil

Silva

Schneider

2019

PAJAR

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AimS: Vitamin D is known to be vital in sustaining musculoskeletal functions, with its deficiency may cause muscle weakness and decreased bone mineral density. Vitamin D inadequacy is highly prevalent and its deficiency or insufficiency estimated to affect one billion people worldwide. It causes secondary hyperparathyroidism, bone loss, fractures and it has been associated with a number of other conditions, such as impaired muscle function (1), we decided to verify if there is an association between 25(OH)D status and handgrip strength and with lean muscle mass after cholecalciferol supplementation in elderly women.Methods : We studied fifty-four postmenopausal women with serum 25(OH)D below 30 ng/mL during three months. Cholecalciferol supplementation was divided into two levels according to classification: deficient (10000 units/day) and insufficient (2000 units/day). Changes in biochemical response and in body composition were assessed using dual-x-ray energy absormetry, handgrip strength and blood tests before and after supplementation.Results: The majority of the sample were vitamin D deficient. There was no difference in the deficient group for handgrip strength after the supplementation (p=0,489), but PTH had a statistically significant reduction (p=0.001). Besides, the deficient group had a decrease in lean mass even after the intervention (p=0.006). The results were similar when comparing within results of the insufficient group, however lean mass remained stable (p=0.423).Conclusion: Three-month cholecalciferol supplementation alone in elderly women with doses according to 25(OH)D serum was insufficient to change handgrip strength and total lean muscle mass, however secondary hyperparathyroidism was corrected.

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Vitamin D and body composition in the elderly

Cited by 30 publications

References 48 publications

High body fat percentage and low consumption of dairy products were associated with vitamin D inadequacy among older women in Malaysia

High body fat percentage and low consumption of dairy products were associated with vitamin D inadequacy among older women in Malaysia

Associations of maternal and fetal vitamin D status with childhood body composition and cardiovascular risk factors

Muscle strength and muscle mass in elderly women after cholecalciferol supplementation in Southern Brazil

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