Vitamin D and Autoimmune Thyroid Diseases - a Review

Miteva, Mariya Zh; Nonchev, Boyan; Orbetzova, Maria; Stoencheva, Snejana D

doi:10.3897/folmed.62.e47794

Cited by 19 publications

(20 citation statements)

References 45 publications

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“…To date, VD deficiency (VDD) is a common finding among the general population worldwide [143], even if it is largely influenced by feeding behaviors (e.g., fortified food consumption is high in Northern Europe) [144]. VD may modulate immune system function, as observed in autoimmune thyroid diseases [145,146]. Activated antigen-presenting cells (APCs), natural killer (NK), T-cell CD4+, and B-cells typically express VD receptors on the cell surface and VD may modulate their activity [147].…”

Section: Parathyroid Glands and Calcium-phosphorus Metabolismmentioning

confidence: 99%

COVID-19 and the Endocrine System: A Comprehensive Review on the Theme

Lisco

Tullio

Stragapede

et al. 2021

JCM

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: Background and aim. The review aimed to summarize advances in the topic of endocrine diseases and coronavirus disease 2019 (COVID-19). Methods. Scientific and institutional websites and databases were searched and data were collected and organized, when plausible, to angle the discussion toward the following clinical issues. (1) Are patients with COVID-19 at higher risk of developing acute or late-onset endocrine diseases or dysfunction? (2) May the underlying endocrine diseases or dysfunctions be considered risk factors for poor prognosis once the infection has occurred? (3) Are there defined strategies to manage endocrine diseases despite pandemic-related constraints? Herein, the authors considered only relevant and more frequently observed endocrine diseases and disorders related to the hypothalamic-pituitary region, thyroid and parathyroid glands, calcium-phosphorus homeostasis and osteoporosis, adrenal glands, and gonads. Main. Data highlight the basis of some pathophysiological mechanisms and anatomical alterations of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-induced endocrine dysfunctions. Some conditions, such as adrenal insufficiency and cortisol excess, may be risk factors of worse clinical progression once the infection has occurred. These at-risk populations may require adequate education to avoid the SARS-CoV-2 infection and adequately manage medical therapy during the pandemic, even in emergencies. Endocrine disease management underwent a palpable restraint, especially procedures requiring obligate access to healthcare facilities for diagnostic and therapeutic purposes. Strategies of clinical triage to prioritize medical consultations, laboratory, instrumental evaluations, and digital telehealth solutions should be implemented to better deal with this probably long-term situation.

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Section: Parathyroid Glands and Calcium-phosphorus Metabolismmentioning

confidence: 99%

COVID-19 and the Endocrine System: A Comprehensive Review on the Theme

Lisco

Tullio

Stragapede

et al. 2021

JCM

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“…Otros autores no han encontrado una correlación entre la TLC y la vitamina D 24 . Ante la presencia de estudios contradictorios, es difícil establecer una conclusión unánime en cuanto a la asociación entre la concentración de vitamina D y la TLC 25 .…”

Section: Introductionunclassified

Caracterización de la concentración sérica de vitamina D en pacientes pediátricos con tiroiditis linfocítica crónica

Sarmiento-Ramón¹,

García-Medina²,

Botero-Restrepo³

et al. 2022

BMHIM

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ha detectado una asociación entre concentraciones bajas de y el desarrollo de la enfermedad. El objetivo de este trabajo fue describir las concentraciones de 25OH vitamina D en pacientes de 5 a 18 años con diagnóstico de tiroiditis linfocítica crónica en tres centros de consulta externa de endocrinología pediátrica en Medellín, Colombia. Métodos: Se llevó a cabo un estudio observacional de corte transversal con recolección retrospectiva de la información. Se evaluaron características sociodemográficas, particularidades del diagnóstico, presencia de comorbilidad y frecuencia de deficiencia de vitamina D. Resultados: Se incluyeron 60 pacientes. La concentración de 25OH vitamina D fue suficiente en el 65% de los casos según los criterios de Institute of Medicine (IOM) y en el 10% de los casos según los criterios de la Endocrine Society. Los valores de calcio y fósforo sérico fueron normales en el 53% y el 45% de los pacientes, respectivamente. Todos los pacientes presentaron concentraciones normales de magnesio y paratohormona. No se encontraron diferencias en el análisis exploratorio al comparar la concentración de 25OH vitamina D, de anticuerpos tiroideos y el volumen tiroideo. Conclusiones: En esta población con tiroiditis linfocítica crónica no se encontró una mayor prevalencia de deficiencia de 25OH vitamina D según los criterios del IOM y de la Endocrine Society en comparación con datos previos de la población general. En el análisis exploratorio no se encontraron diferencias estadísticamente significativas.

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“…Subsequently, D 3 is transported back to the liver and converted to 25(OH)D 3 by several cytochrome P450 mixed-function oxidases (CYP), such as CYP27A1, CYP3A4, and especially CYP2R1 [6,7]. 25(OH)D 3 is the storage form of VitD, and consequently due to its half-life of 2-3 weeks [8], the best marker to monitor VitD status. 1.25(OH) 2 D 3 may impact pathogenesis and prognosis of chronic, malignant, and endocrine disease [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

A rapid point-of-care assay accurately measures vitamin D

Albrecht

Lotz

Frommer

et al. 2021

J Endocrinol Invest

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Purpose Vitamin D (VitD) is a pleiotropic hormone with effects on a multitude of systems and metabolic pathways. Consequently, the relevance of a sufficiently high VitD serum level becomes self-evident. Methods A rapid immunofluorescence assay designed for the point-of-care measurement of serum VitD3 solely was tested. Inter- and intra-assay validation, double testing and result comparison with a standardized laboratory method were performed. Results An overall linear correlation of r = 0.89 (Pearson, 95% CI 0.88–0.92, p < 0.01) between the point of care and the conventional reference assay was registered. Accuracy and precision were of special interest at cut-points (10 ng/ml [mean deviation 1.7 ng/ml, SD 1.98 ng/ml, SE 0.16 ng/ml], 12 ng/ml [MD 0.41, SD 1.89, SE 0.19] and 30 ng/ml [MD − 1.11, SD 3.89, SE 0.35]). Only a slight deviation was detected between the two assays when using fresh (r = 0.91, 95% CI 0.86–0.94, p < 0.01) and frozen serum samples (r = 0.86, 0.82–0.89, p < 0.01). Results remained steady when samples were frozen several times. Inter- and intra-assay validation according to the CLSI protocol as well as multiuser testing showed stable results. Conclusion This novel, innovative, and controlled study indicates that the evaluated rapid point of care VitD assay is reliable, accurate, and suited for clinical practice.

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Vitamin D and Autoimmune Thyroid Diseases - a Review

Cited by 19 publications

References 45 publications

COVID-19 and the Endocrine System: A Comprehensive Review on the Theme

COVID-19 and the Endocrine System: A Comprehensive Review on the Theme

Caracterización de la concentración sérica de vitamina D en pacientes pediátricos con tiroiditis linfocítica crónica

A rapid point-of-care assay accurately measures vitamin D

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