Vitamin D and atherosclerosis

Menezes, Arthur R.; Lamb, Marie C.; Lavie, Carl J.; DiNicolantonio, James J.

doi:10.1097/hco.0000000000000108

Cited by 68 publications

(58 citation statements)

References 81 publications

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“…Another point of importance is that the risk of cardiovascular diseases and metabolic syndrome has been found to be associated with psychotic disorders (Johnsen et al, 2011;Ringen et al, 2014). Increased cardiovascular risk is also related to inadequate S-25 OH D levels (Choi et al, 2014;Menezes et al, 2014;Ruwanpathirana et al, 2014). Elevated risk of cardiovascular disease and metabolic syndrome in psychotic disorder in visible ethnic minorities has been demonstrated in long-term follow-ups (Henderson et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Nerhus

Berg

Dahl

et al. 2015

Psychiatry Research

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Vitamin D deficiency is common among patients with psychotic disorders and could be due to unknown disease mechanisms or contingent factors. However most studies are performed in chronic patients and have often failed to address the influence of ethnicity on vitamin D levels in clinical samples. We investigated serum concentrations of 25-hydroxy vitamin D (S-25 OH D) in first episode patients compared to patients with multi episodes and healthy controls; with a specific focus on differences between visible ethnic minorities and participants from the majority population. A total of 284 participants were included in this cross-sectional study. First episode patients with a DSM-IV psychotic disorder were matched on age, gender and ethnicity to participants from a multi episode patient sample (1:1) and healthy controls (1:2). We did not find any differences between either patient groups or the healthy controls, but participants from visible ethnic minorities had significantly lower S-25 OH D than participants from the majority population. This implies that S-25 OH D should be routinely measured in persons from visible ethnic minorities since low levels are associated with higher levels of depressive symptoms.

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Section: Discussionmentioning

confidence: 99%

Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Nerhus

Berg

Dahl

et al. 2015

Psychiatry Research

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“…From a clinical perspective, there are many ongoing studies showing that 1,25-dihydroxyvitamin D3 or its synthetic analogs can have anti-cancer effects, and can have beneficial effects on cardiovascular or autoimmune disease (Delvin et al, 2014; James et al, 1998; Menezes et al, 2014). Since there is some evidence supporting a role for HCMV infection in the progression of cancers (Michaelis et al, 2011; Soroceanu and Cobbs, 2011), cardiovascular and autoimmune diseases (Caposio, Orloff, and Streblow, 2011; Varani et al, 2009), our study could prompt questions regarding whether or not 1,25-dihydroxyvitamin D3 and its synthetic analogs should be used therapeutically.…”

Section: Discussionmentioning

confidence: 99%

The human cytomegalovirus lytic cycle is induced by 1,25-dihydroxyvitamin D3 in peripheral blood monocytes and in the THP-1 monocytic cell line

Miller

2015

Virology

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Human cytomegalovirus (HCMV) resides in a latent form in hematopoietic progenitors and undifferentiated cells within the myeloid lineage. Maturation and differentiation along the myeloid lineage triggers lytic replication. Here, we used peripheral blood monocytes and the monocytic cell line THP-1 to investigate the effects of 1,25-dihydroxyvitamin D3 on HCMV replication. Interestingly, 1,25-dihydroxyvitamin D3 induces lytic replication marked by upregulation of HCMV gene expression and production of infectious virus. Moreover, we demonstrate that the effects of 1,25-dihydroxyvitamin D3 correlate with maturation/differentiation of the monocytes and not by directly stimulating the MIEP. These results are somewhat surprising as 1,25-dihydroxyvitamin D3 typically boosts immunity to bacteria and viruses rather than driving the infectious life cycle as it does for HCMV. Defining the signaling pathways kindled by 1,25-dihydroxyvitamin D3 will lead to a better understanding of the underlying molecular mechanisms that determine the fate of HCMV once it infects cells in the myeloid lineage.

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“…In fact, some researchers have suggested using nutraceuticals as adjuvants in the clinical practice (Braithwaite et al, 2014;Fergurson, 2009). Among nutraceuticals, vitamin D is related to a reduction on atherosclerosis, insulin resistance, dyslipidemia and hypertension (Menezes, Lamb, Lavie, & DiNicolantonio, 2014). A dietary supplemental containing gamma linolenic acid, vitamin E, vitamin C, beta carotene and coenzyme Q10 may be considered in the treatment and prevention of dry skin associated with the use of oral isotretinoin (Fabbrocini et al, 2014).…”

Section: Final Remarksmentioning

confidence: 98%