Vitamin D and asthma in children: insights from total and free 25-hydroxyvitamin D and vitamin D binding protein measurements

Abstract

What is already known about this topic? Our study confirm that vitamin D deficit is related to asthma. The strength of our study is that it's currently the only study that assessed total and free 25(OH)D all together in children with asthma.What does this article add to our knowledge? The total and free serum levels of 25 (OH) D are lower in asthmatic children than healthy ones. Despite expectations, in patients who least control asthmatic symptoms and who have worse respiratory function, total and free vitamin D levels are not significantly lower.How does this study impact current management guidelines? Free vitamin D is rarely investigated in asthmatic children, so further studies are needed to evaluate the relationship about free vitamin D and lung inflammation.

Investigating Vitamin D-Binding Protein’s Role in Childhood Health and Development

“…In another study including 50 atopic children with mild-to-moderate persistent asthma and 40 healthy children, all aged 6–16 years, asthmatic children have lower levels of total and free 25(OH)D compared to healthy children. DBP levels were comparable between the two groups and no correlation between vitamin D status and asthma control or lung function was observed [ 56 ].…”