Vitamin D and Allergic Disease: Sunlight at the End of the Tunnel?

Jones, Anderson P.; Tulic, Meri K.; Rueter, Kristina; Prescott, Susan L.

doi:10.3390/nu4010013

Cited by 40 publications

(31 citation statements)

References 79 publications

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“…Although it is known that VD suppresses the proliferation of Th1 lymphocytes by suppressing the IL-12 production in the adaptive immune system, its effect on the Th2 lymphocytes is controversial. There are also studies that indicate VD increases Th2 lymphocytes by increasing IL-4, IL-5 and IL-13, or plays an inhibitor role (4). There are studies in the literature supporting either hypothesis.…”

Section: Discussionmentioning

confidence: 99%

“…While being a strong regulator of the adaptive immune system, it also plays a role in stimulating the innate immune response against infections (4). It is also reported that VD supplementation of children in the winter months decreases the frequency of respiratory tract infections (10).…”

Section: Introductionmentioning

confidence: 99%

“…Simultaneously with the allergy epidemic taking place during this period, the use of vitamin D (VD) all over the world brings up the question 'is there a connection between allergic diseases and VD supplements' (4,5). Various birth cohort studies have suggested that VD deficiency could be one of the reasons for this global allergic disease epidemic (6,7).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Relationship Between Vitamin D Deficiency and Wheezing in Young Children; A Randomized Study

Mansuroğlu

Altıntaş

Doğruel

2017

Asthma Allergy Immunol

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ÖZGiriş: D vitamini (VD) immünolojik süreçlerde kritik bir rol oynamaktadır ve çeşitli allerjik ve enfeksiyöz hastalıkların gelişimindeki rolünü araştırmak için çalışmalar yürütülmektedir. Çalışmanın amacı, çocuklarda 25(OH)D düzeyini etkileyen faktörleri belirlemek ve VD ile vizing, allerji ve enfeksiyonlar arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem:Çalışmaya, 18-24 ay arasında 64 çocuk dahil edildi. Çalışmanın başında ve sonunda fizik muayene yapıldı, kan örnekleri alındı ve aileler bir anket doldurdu. İlk vizitte çocukların yarısına 400 ünite VD desteği önerildi. Çalışmanın 3., 6. ve 12. aylarında takip vizitleri planlandı. ABSTRACTObjective: Vitamin D (VD) plays a critical role in immunological processes and studies have been conducted to investigate its role in the development of several allergic and infectious diseases. The aim of this study was to determine the factors that affect the 25(OH)D level in children, and also to assess the relationship between VD and wheezing, allergy, and infection. Materials and Methods:Sixty-four children between 18-24 months of age were included in this study. At the beginning and at the end of the study, a physical examination was performed, blood samples were taken, and parents completed the questionnaire. Half of the children had been recommended at the first visit to take daily 400 units of VD. Follow-up visits were scheduled at the 3rd, 6th and 12th months of the study. Results:The mean age of the infants participating in the study was 20.3±1.5 months. 46.9% (n=30) of the infants were female and 53.1% (n=34) were male. While the 25(OH)D level was 29.8±10.8 ng/ml at the beginning of the study, it was 26.5±10.3 ng/ml (p=0.017) at the end of the study. The percentage of patients with sufficient 25 (OH) D levels was 48.4% (n = 31) at the beginning of the study and 29.7% (n = 19) at the end of the study (p=0.010). A statistically significant relationship was determined between VD intake and serum 25(OH)D level. At the beginning and at the end of the study, the 25(OH)D level was statistically inversely correlated with wheezing. Low 25(OH)D levels were also found to be a risk factor for the development of wheezing. No statistically significant relationship was determined between the serum 25(OH)D level and allergic and respiratory outcomes. Conclusion:When the factors which effect 25(OH)D level were examined, it was only associated with VD supplementation. VD deficiency showed a significant relationship with wheezing development, regardless of supplementation of VD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Relationship Between Vitamin D Deficiency and Wheezing in Young Children; A Randomized Study

Mansuroğlu

Altıntaş

Doğruel

2017

Asthma Allergy Immunol

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“…This is also implicated in a corresponding rise in immune-mediated and inflammatory diseases, including allergic diseases, in the same regions of the world. Recognised immunomodulatory properties of vitamin D provide a plausible biological basis for epidemiological associations between surrogate markers of sunlight exposure (such as latitude) and higher allergy prevalence (reviewed in [69]). …”

Section: Vitamin Dmentioning

confidence: 99%

Developing Primary Intervention Strategies to Prevent Allergic Disease

Rueter

Haynes

Prescott

2015

Curr Allergy Asthma Rep

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Allergic diseases are a major cause of morbidity in the developed world, now affecting up to 40 % of the population with no evidence that this is abating. If anything, the prevalence of early onset allergic diseases such as eczema and food allergy appears to be still increasing. This is almost certainly due to the changing modern environment and lifestyle factors, acting to promote immune dysfunction through early perturbations in immune maturation, immune tolerance and regulation. This early propensity to inflammation may also have implications for the rising risk of other inflammatory non-communicable diseases (NCDs) later in life. Identifying risk factors and pathways for preventing early onset immune disease like allergy is likely to have benefits for many aspects of human health, particularly as many NCDs share similar risk factors. This review focuses on recent advances in primary intervention strategies for promoting early immune health and preventing allergic disease, highlighting the current evidence-based guidelines where applicable and areas requiring further investigation.

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“…A growing evidence based medicine confirmed its important roles in tissues other than bones tissues [1]. Previous researches reported that vitamin D insufficiency or deficiency was involved in pathogenesis of many disorders like psychiatric disorders namely austic spectrum disorders (ASD) [2,3], cardiac diseases complicating diabetes mellitus and hypertension [4], systemic Lupus erythematosis (SLE), juvenile idiopathic arthritis, Crohn's disease [5], malignancy [6], some respiratory viruses and reactive airway diseases [7] even multiple sclerosis in adults [8]. Authors suspected that in vitamin D deficiency, all endocrinal, autocrinal and paracrine functions of vitamin D disturb leading to variable forms of diseases.…”

Section: -Hydroxy Vitamin D (25 Ohmentioning

confidence: 99%