Vitamin D and alcohol: A review of the current literature

Tardelli, Vítor S.; Lago, Mariana Pimentel Pádua do; Silveira, Dartiu Xavier da; Fidalgo, Thiago M.

doi:10.1016/j.psychres.2016.10.051

Cited by 49 publications

(43 citation statements)

References 27 publications

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“…Several explanations have been given for negative association but exact biochemical explanation for positive association is not known. A speculative explanation given to this is that alcohol could suppress parathyroid hormone (PTH) levels and therefore 25 hydroxy Vitamin D (25OH vit D) is elevated as a result of reduced vitamin D activation in kidney, causing high measurable vitamin D levels (26) .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of vitamin D deficiency/insufficiency and its metabolic associations in an urban setting in Sri Lanka: data from Colombo urban study

Subasinghe

Gunawardane

Ediriweera

et al. 2019

Sri Lanka J. Diabetes Endocrinol. Metab.

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Correspondence Introduction:Vitamin D deficiency is a commonly prevalent, but less attended problem in Asia. Vit D status has many metabolic associations. We designed this community-based study to describe the prevalence of vitamin D deficiency/insufficiency and its metabolic associations in Sri Lankan population. Methods:A representative sample aged 18 years and above was included. Demographic, anthropometric, and social details were recorded using a standard proforma. Blood analysis was done for vitamin D status, and other metabolic parameters. Prevalence was estimated using weighted age standardized calculations. Multiple logistic regression analyses were used to study associations to vitamin D status. Results:Cumulative community prevalence of Vit D deficiency and insufficiency was 90.2%. Prevalence was highest among young and females. Obese had significantly lower vitamin D levels. According to the linear regression, Moors showed a significantly lower Vit D levels compared to Sinhalese while Triglyceride levels showed an inverse association with Vit D levels. Dysglycaemia was not associated with Vit D deficiency. Discussion:Very high prevalence of Vit D problem was anticipated on clinical grounds and this is comparable with regional data. High prevalence among young needs early attention to avoid future poor bone health outcomes. Moor ethnicity shows high rates due to many known factors. Obesity is an emerging health problem in the country and co existent Vit D deficiency would increase its burden. Conclusion:Vitamin D deficiency and insufficiency and other metabolic problems are highly prevalent in this population. Causative factors and consequences of this problem should be further researched to plan strategies to replete the Vit D and prevent this problem.

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Section: Discussionmentioning

confidence: 99%

Prevalence of vitamin D deficiency/insufficiency and its metabolic associations in an urban setting in Sri Lanka: data from Colombo urban study

Subasinghe

Gunawardane

Ediriweera

et al. 2019

Sri Lanka J. Diabetes Endocrinol. Metab.

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“…Vitamin D regulates physiological functions by controlling the metabolism of calcium and phosphates, stimulates growth, and promotes the necessary remodeling of bones and teeth [6]. Vitamin D deficiency is often associated with bone disorders (such as rickets, osteomalacia, and osteoporosis); when serum calcium decreases, the thyroid gland immediately releases parathyroid hormone (PTH), which acts by stimulating bone reabsorption and reduction of calcium urinary excretion [7].…”

Section: Vitamin D and Bone Healthmentioning

confidence: 99%

Vitamin D and Its Deficiency in Saudi Arabia

Bokhari¹,

Albaik²

2020

Vitamin D Deficiency

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Vitamin D is a hot topic that has attracted attention over the past 10 years, especially since a large proportion of people suffer from this nutrient deficiency. Vitamin D deficiency is estimated to be about 1 billion people all over the world and 50% in Asia and the Middle East. Saudi Arabia has also demonstrated a high prevalence of vitamin D deficiency among healthy Saudi individuals. This chapter provides, in detail, a clear and understandable identification of vitamin D, its function, source, synthesis, metabolism, status, and deficiency. The chapter also focuses on studying vitamin D deficiency in Saudi Arabia based on PubMed's initial research criteria.

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“…Vitamin D deficiency, defined as lower than 50 nmol/L of 25-hydroxy vitamin D (25(OH)D), is increasingly recognized as a global public health problem [10]. Indeed, vitamin D deficiency is prevalent in alcoholics [11]. A clinical study found that low 25(OH)D levels were associated with increased mortality in ALD [12].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency Aggravates Hepatic Oxidative Stress and Inflammation during Chronic Alcohol-Induced Liver Injury in Mice

Chu

et al. 2020

Oxidative Medicine and Cellular Longevity

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Vitamin D deficiency has been reported in alcoholics. This study is aimed at evaluating the effects of vitamin D deficiency on chronic alcohol-induced liver injury in mice. Mice were fed with modified Lieber-DeCarli liquid diets for 6 weeks to establish an animal model of chronic alcohol-induced liver injury. In the VDD+EtOH group, mice were fed with modified diets, in which vitamin D was depleted. Vitamin D deficiency aggravated alcohol-induced liver injury. Furthermore, vitamin D deficiency aggravated hepatocyte apoptosis during alcohol-induced liver injury. Although it has a little effect on hepatic TG content, vitamin D deficiency promoted alcohol-induced hepatic GSH depletion and lipid peroxidation. Further analysis showed that vitamin D deficiency further increased alcohol-induced upregulation of hepatic inducible nitric oxide synthase (inos), two NADPH oxidase subunits p47phox and gp91phox, and heme oxygenase- (HO-) 1. By contrast, vitamin D deficiency attenuated alcohol-induced upregulation of hepatic antioxidant enzyme genes, such as superoxide dismutase (sod) 1 and gshpx. In addition, vitamin D deficiency significantly elevated alcohol-induced upregulation of hepatic proinflammatory cytokines and chemokines. Taken together, these results suggest that vitamin D deficiency aggravates hepatic oxidative stress and inflammation during chronic alcohol-induced liver injury.

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Vitamin D and alcohol: A review of the current literature

Cited by 49 publications

References 27 publications

Prevalence of vitamin D deficiency/insufficiency and its metabolic associations in an urban setting in Sri Lanka: data from Colombo urban study

Prevalence of vitamin D deficiency/insufficiency and its metabolic associations in an urban setting in Sri Lanka: data from Colombo urban study

Vitamin D and Its Deficiency in Saudi Arabia

Vitamin D Deficiency Aggravates Hepatic Oxidative Stress and Inflammation during Chronic Alcohol-Induced Liver Injury in Mice

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