Vitamin D and 1,25(OH)2D Regulation of T cells

Cantorna, Margherita T.; Snyder, Lindsay M.; Yang, Lin; Yang, Linlin

doi:10.3390/nu7043011

Cited by 469 publications

(353 citation statements)

References 59 publications

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“…The inhibitory effects of 1,25(OH) 2 D on T cell production of IL-17, IFN-␥, and IL-2 are identical in human and mouse cells (11,12,24,25). The induction of FoxP3 ϩ T reg cells by 1,25(OH) 2 D has also been demonstrated to occur in human and mouse T cells (11,12,24,25). Some pathways are not identical; for example, the 1,25(OH) 2 D-induced production of cathelicidin occurs only in human but not mouse macrophages (2).…”

Section: Vitamin D and Human Pulmonary Infectionmentioning

confidence: 95%

Vitamin D and Lung Infection

Cantorna

2016

Infect Immun

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Available data suggest that vitamin D plays a role in controlling inflammation in the lungs. However, to date vitamin D-induced production of cathelicidin has not been shown to have an effect on the burden of either viruses or bacteria. Future work should continue to determine the effects of vitamin D-regulated mechanisms in the lung and the possible role of cathelicidin against different pulmonary pathogens in vivo.

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Section: Vitamin D and Human Pulmonary Infectionmentioning

confidence: 95%

Vitamin D and Lung Infection

Cantorna

2016

Infect Immun

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“…Ancak net bir şekilde implantolojide D vitamini takibinin rutin olarak yapılamamış olması bu konuda ortaya konulacak kanıtlar için bir eksikliktir. 66 Vitamin D yetersizliği ve implantların erken kaybı arasındaki ilişki net olarak kanıtlanamamıştır. [66][67][68][69][70][71][72] D Vitamini periodontal hastalığın riskini kemik mineral dansitesi veya immunmodülatör olarak etkilemektedir.…”

Section: Ağiz Sağliği Açisinda Yeni̇ Tedavi̇ Yaklaşimlariunclassified

Vitamin D and It's Importance in Oral Healt

Turgut¹,

Palancıoğlu²,

Yaltırık³

2018

Turkiye Klinikleri J Dental Sci

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“…T cell is also the target of vitamin D3 for immunomodulation. 35 Four major mechanisms of calcitriol influencing T cells proposed are: (1) direct effects due to systemic calcitriol levels; (2) intracrine effects due to the synthesis of calcitriol by the T cells; (3) paracrine effects of the APCs, which also synthesizes calcitriol, and (4) indirect effects due to changes in the APC, which present less antigen. As already said, calcitriol induces the more immature and tolerogenic forms of monocytes during their differentiation and maturation into DCs.…”

Section: Innate Lymphoid Cellsmentioning

confidence: 99%

Role of Active Vitamin D3 in Immunity

Singh¹,

Verma²,

Singh³

et al. 2017

Indian Journal of Medical Biochemistry

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precursor 25 hydroxy cholecalciferol. Only recently, its crucial role as a potential immune modulator has been recognized. Clear identification of its well-documented roles in immune response and autoimmunity has led it to being actively pursued as a potential therapeutic agent. 1,2 Vitamin D3 influences all the key cells of the immune system and produces intracrine and paracrine effects on them. Most immune cells have the enzyme system to produce the active form of vitamin D3. It is an inhibitor of differentiation and maturation of dendritic cells (DCs) and decreases their antigen-presenting activity. It acts directly on T cells and alters the profile of their proliferation and differentiation. It promotes anti-inflammatory environment by inhibiting the Th1 and Th17 cells and promoting the Th 2 and T reg cell differentiations. Vitamin D3 induces antimicrobial effects in monocytes/macrophages by enhancing their phagocyte activity as well as helping the synthesis of antimicrobial peptides. Sunlight-mediated epidermal expression of 1,25(OH) 2 D3 acts as the link between the environment and immune system. It induces suppression of cutaneous immune response through the T-regulatory cells. Overall, it is considered an important regulator of both innate and adaptive immune systems. There is an emerging view that the vitamin D deficiency, which is widely prevalent these days, could have an important role in immune disorders, especially the autoimmune diseases. 2In this review, we present an overview of the current knowledge on vitamin D as an immunomodulator with the underlying molecular mechanisms and its possible role in immunological response with future implications. VITAMIN D-THE MOLECULEErgocalciferol, vitamin D2, and cholecalciferol, vitamin D3, are the two major forms of vitamin D. Vitamin D2 is synthesized by plants and fungi, while vitamin D3 is produced in large quantities in humans by photosynthesis in the skin. The ultraviolet (UV) light falling on the skin catalyzes the conversion of 7-dehydro-cholesterol into the previtamin D, which then spontaneously ABSTRACT Introduction:The active vitamin D3-1,25 dihydroxy cholecalciferol-is the key player in calcium and phosphorus metabolism and skeletal growth and functions. However, recent new developments have revealed its role in other tissues as well, referred to as the nonclassical actions of vitamin D. Not only the endocrinal effects, evidence indicates that vitamin D3 also has autocrine and paracrine functions due to its extrarenal synthesis by many cells, including the immune cells. All cells of the immune system have vitamin D receptors and show wide-ranging effects to it. It impacts both the innate and adaptive immune systems and the overall influence points to anti-infective, anti-inflammatory, immunosuppressive, and regulatory roles. It shows a significant role in chronic inflammatory and autoimmune diseases as well in susceptibility to infections.In this review, newer developments on the role of vitamin D in immunity and the underlying mechanism are d...

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Vitamin D and 1,25(OH)2D Regulation of T cells

Cited by 469 publications

References 59 publications

Vitamin D and Lung Infection

Vitamin D and Lung Infection

Vitamin D and It's Importance in Oral Healt

Role of Active Vitamin D3 in Immunity

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