Vitamin D analogs decrease in vitro secretion of RANTES and enhance the effect of budesonide

Vitamin D3 as a novel regulator of basic fibroblast growth factor in chronic rhinosinusitis with nasal polyposis

“…Based on our results, it is possible that the inverse relationship between bFGF and VD3 in patients with CRSwNP could explain these findings. In a similar study from the same group, the administration of topical calcitriol or tacalcitol, a synthetic VD3 analogue, also significantly down-regulated NP fibroblast production of RANTES in a dose-dependent fashion [9]. Again, these effects were augmented by combining VD3 with a topical steroid.…”

“…Numerous inflammatory mediators have been shown to be altered in CRS [18]; however, the mediators investigated in this study were selected because there is evidence to support an association between VD3 and their expression [8, 9, 10]. MCP-1, also known as CCL2, is one of the key chemokines that regulates migration and infiltration of monocytes and macrophages to sites of inflammation.…”

“…The goal of this present investigational study is to ascertain if there is a significant correlation between systemic levels of 25-VD3 and levels of monocyte chemoattractant protein-1 (MCP-1), Regulated upon Activation Normal T cell Expressed and Secreted (RANTES) and basic fibroblast growth factor (bFGF). These mediators were selected because they are known to be altered in patients with CRS and are reported to be impacted by VD3 [8,9,10]…”

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

“…899 In addition to suppressing fibroblast proliferation, 1,25VD 3 and tacalcitol inhibited production of the proinflammatory cytokines IL-6, IL-8, and RANTES (an eosinophil/lymphocyte chemoattractant) by activated human NP fibroblasts. 900,901 With regard to suppressing RANTES production, a synergistic effect was observed when budesonide was added to 1,25VD 3 or tacalcitol as compared to monotherapy. Finally, studies on 1,25VD 3 or tacalcitol-exposed fibroblasts did not show a shift in BCL-2/BAX gene expression in a proapoptotic direction.…”

Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps

“…There is increasing evidence that the fibroblast is at least partially responsible for recruitment of inflammatory cells in CRS . In CRSwNP, 1,25VD3 has been shown to decrease eosinophil attractant chemokine release from human sinonasal fibroblasts (HSNFs) in vitro . Furthermore, although HSNFs can respond to VD3, they lack the ability to convert VD3 to its metabolically active form 1,25VD3.…”