Vitamin D alleviates hypoxia/reoxygenation-induced injury of human trophoblast HTR-8 cells by activating autophagy

Pi, Yalei; Tian, Xiaoyu; Ma, Jing; Zhang, Huifeng; Huang, Xianghua

doi:10.1016/j.placenta.2021.05.008

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…The physiological function of VD is to control calcium homeostasis for maintaining bone mineralization. Moreover, VD can modulate innate and adaptive immunity, induce cell differentiation, apoptosis, and autophagy; inhibit cell proliferation, angiogenesis and metastasis; and regulate other cellular signaling processes ( El-Sharkawy and Malki, 2020 ; Adelani et al, 2021 ; Murdaca et al, 2021 ; Pi et al, 2021 ; Poursoltani et al, 2021 ; Zhao et al, 2021 ; Bhutia, 2022 ; Zhou et al, 2022 ). Since VD levels obtained from diet are often insufficient and VD deficiency is associated with a variety of diseases, a daily supplement of at least 25 μg (1,000 IU) of VD is recommended to prevent VD deficiency ( Holick et al, 2011 ).…”

Section: Vitamin D—metabolism Analogues and Functionsmentioning

confidence: 99%

Vitamin D: A Potential Star for Treating Chronic Pancreatitis

Zheng

Gao

2022

Front. Pharmacol.

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Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the pancreas. The incidence of CP is increasing worldwide but the effective therapies are lacking. Hence, it is necessary to identify economical and effective agents for the treatment of CP patients. Vitamin D (VD) and its analogues have been confirmed as pleiotropic regulators of cell proliferation, apoptosis, differentiation and autophagy. Clinical studies show that VD deficiency is prevalent in CP patients. However, the correlation between VD level and the risk of CP remains controversial. VD and its analogues have been demonstrated to inhibit pancreatic fibrosis by suppressing the activation of pancreatic stellate cells and the production of extracellular matrix. Limited clinical trials have shown that the supplement of VD can improve VD deficiency in patients with CP, suggesting a potential therapeutic value of VD in CP. However, the mechanisms by which VD and its analogues inhibit pancreatic fibrosis have not been fully elucidated. We are reviewing the current literature concerning the risk factors for developing CP, prevalence of VD deficiency in CP, mechanisms of VD action in PSC-mediated fibrogenesis during the development of CP and potential therapeutic applications of VD and its analogues in the treatment of CP.

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Section: Vitamin D—metabolism Analogues and Functionsmentioning

confidence: 99%

Vitamin D: A Potential Star for Treating Chronic Pancreatitis

Zheng

Gao

2022

Front. Pharmacol.

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“…Moreover, placental malperfusion seen in preeclamptic placentas results in some areas being hyperoxic while others relatively hypoxic rather than the placenta just being hypoxic ( Staff, 2019 ; Burton et al, 2021 ). This cycle of hypoxia-reoxygenation in PE could lead to differences in cellular responses to oxidative stress ( Mukherjee et al, 2021 ; Pi et al, 2021 ; Qiu et al, 2021 ). Regardless, these studies demonstrated the emerging complexities of the role of miR-210-3p in placental development and the need to better understand its function in pregnancy.…”

Section: Microrna Regulation Of Trophoblast Invasion Spiral Artery Re...mentioning

confidence: 99%

Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia

Hayder

Shan²,

Chen³

et al. 2022

Front. Cell Dev. Biol.

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It is now well-established that microRNAs (miRNAs) are important regulators of gene expression. The role of miRNAs in placental development and trophoblast function is constantly expanding. Trophoblast invasion and their ability to remodel uterine spiral arteries are essential for proper placental development and successful pregnancy outcome. Many miRNAs are reported to be dysregulated in pregnancy complications, especially preeclampsia and they exert various regulatory effects on trophoblasts. In this review, we provide a brief overview of miRNA biogenesis and their mechanism of action, as well as of trophoblasts differentiation, invasion and spiral artery remodeling. We then discuss the role of miRNAs in trophoblasts invasion and spiral artery remodeling, focusing on miRNAs that have been thoroughly investigated, especially using multiple model systems. We also discuss the potential role of miRNAs in the pathogenesis of preeclampsia.

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“…The mTOR inhibition rescued high-glucose-induced pancreatic β-cell pyroptosis through blocking the formation of NLRP3 inflammasome (230). Pi et al reported that vitamin D decreased ROS and activated autophagy, which prevented pyroptosis that induced by hypoxia/reoxygenation (H/R) in trophoblasts (231).…”

Section: Vitamin D and Regulated Necrosismentioning

confidence: 99%

Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species

Zhang

Liu²,

Dai³

et al. 2022

Front. Nutr.

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The discovery of regulated necrosis revitalizes the understanding of necrosis from a passive and accidental cell death to a highly coordinated and genetically regulated cell death routine. Since the emergence of RIPK1 (receptor-interacting protein kinase 1)-RIPK3-MLKL (mixed lineage kinase domain-like) axis-mediated necroptosis, various other forms of regulated necrosis, including ferroptosis and pyroptosis, have been described, which enrich the understanding of pathophysiological nature of diseases and provide novel therapeutics. Micronutrients, vitamins, and minerals, position centrally in metabolism, which are required to maintain cellular homeostasis and functions. A steady supply of micronutrients benefits health, whereas either deficiency or excessive amounts of micronutrients are considered harmful and clinically associated with certain diseases, such as cardiovascular disease and neurodegenerative disease. Recent advance reveals that micronutrients are actively involved in the signaling pathways of regulated necrosis. For example, iron-mediated oxidative stress leads to lipid peroxidation, which triggers ferroptotic cell death in cancer cells. In this review, we illustrate the crosstalk between micronutrients and regulated necrosis, and unravel the important roles of micronutrients in the process of regulated necrosis. Meanwhile, we analyze the perspective mechanism of each micronutrient in regulated necrosis, with a particular focus on reactive oxygen species (ROS).

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Vitamin D alleviates hypoxia/reoxygenation-induced injury of human trophoblast HTR-8 cells by activating autophagy

Cited by 9 publications

References 36 publications

Vitamin D: A Potential Star for Treating Chronic Pancreatitis

Vitamin D: A Potential Star for Treating Chronic Pancreatitis

Role of microRNAs in trophoblast invasion and spiral artery remodeling: Implications for preeclampsia

Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species

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