Vitamin Cobalamin deficiency in macrocytic anemia reporting at a Tertiary Care Hospital.

Abstract

Objective: Determine the frequency of vitamin cobalamin deficiency in macrocytic anemia cases reporting at tertiary care hospital. Study Design: Cross Sectional study. Setting: Faculty of Medicine and Allied Medical Sciences, Isra University, Hyderabad, Sindh Pakistan. Period: January 2017 to October 2018. Material & Methods: 450 cases of both genders, diagnosed as macrocytic- megaloblastic anemia were studied for the vitamin Cobalamin levels. Cases were collected through non- probability convenient sampling by inclusion and exclusion criteria. Consenting volunteers were asked for blood sampling. 5 mL blood was taken from ante – cubital fossa. Samples were centrifuged and sera were collected for the estimation of vitamin cobalamin by ELISA – assay kit. Continuous and categorical variables were entered in SPSS (version 21.0) and analyzed by Student t-test and Chi-square test respectively at 95% CI (P ≤ 0.05). Results: Male and female comprised 225 (43.3%) and 294 (56.6%) of 519 subjects. Male to female ratio was noted 1.30:1. MCV, MCH and MCHC show statistically significant difference between male and female (P<0.05). MCV in male was 96.8±9.92 fl vs. 105.5±12.04 fl in female (P=0.0001). Normal cobalamin was noted in 15.2% (n= 79) and any type of cobalamin deficiency was noted in 84.7% (n= 440) (P=0.0001). Conclusion: The present study reports frequency of 84.7% Cobalamin deficiency in macrocytic anemia reporting at Indus Medical College Hospital. Further studies are recommended by the treating physicians.

Association of Low Ferritin Level of new Born with Iron Deficiency Anemia in Mothers

“…In distribution of women based on severity of low ferritin levels amongst 90 women, 41 (45.56%) women were observed with mild low ferritin levels, 43 (47.78%) women were observed with moderate low ferritin levels while 6 (6.66%) women were observed with severe low ferritin levels. In accordance with our study, another study carried out by NB Shaikh et al reported that mild, moderate and severe Low ferritin level in newborns were observed in 48.15%,45.37%, and 6.48% respectively 16 . Another study piloted by Shams et al reported that 43.5% of the newborns were in range of 12-30 ng/ml Serum ferritin levels 20 .…”

“…Based on hemoglobin level of participants with iron deficiency anemia, 52 (34.67%) women were observed with mild iron deficiency anemia, moderate iron deficiency anemia was observed in 87 (58%) women while 13 (8.67%) women were observed with severe iron deficiency anemia. In accordance with our study, another study carried out by NB Shaikh et al reported that mild, moderate and severe iron deficiency anemia amongst their study participants was observed in 31.52%, 61.41% and 7.07% women respectively 16 . Another study done by Qazi et al reported mild anemia in 52.5% participants, mild anemia in 27.5% and severe anemia in 19.9% which is consistent with our findings .…”

Frequency of Vitamin Cobalamin Deficiency in Macrocystic Anemia Cases Reporting at Tertiary Care Hospital

“…These findings were comparable to the previous some studies. [17,18] Most common symptoms were loss of weight, brittle nails, fast heartbeat, shortness of breath, fatigue and pale skin among all 210 patients. In the current study, the MCV for men was 97.6±5.32 fl vs. 107.5±11.08 fl for women (P=0.0001), indicating higher values.…”